Ceramic thermal wind sensor based on advanced direct chip attach package

An advanced direct chip attach packaged two-dimensional ceramic thermal wind sensor is studied. The thermal wind sensor chip is fabricated by metal lift-off processes on the ceramic substrate. An advanced direct chip attach (DCA) packaging is adopted and this new packaged method simplifies the processes of packaging further. Simulations of the advanced DCA packaged sensor based on computational fluid dynamics (CFD) model show the sensor can detect wind speed and direction effectively. The wind tunnel testing results show the advanced DCA packaged sensor can detect the wind direction from 0° to 360° and wind speed from 0 to 20 m/s with the error less than 0.5 m/s. The nonlinear fitting based least square method in Matlab is used to analyze the performance of the sensor.     

利用玉米淀粉黄浆水发酵生产细菌纤维素的培养基优化

玉米淀粉黄浆水是生产淀粉过程中排放的高浓度有机废水,以其作为Acetobacter xylinum DS398的基础培养基发酵细菌纤维素。采用Plackett-Burman设计和Box-Behnken响应面分析法对培养基成分进行优化,并对产物进行表征。以纤维素干重为响应值,从7个相关影响因素筛选出3个显著因子:蔗糖、磷酸二氢钾和乙醇。在此基础上,根据Box-Behnken响应面分析法确定以上三因素的最佳浓度。最优的玉米淀粉黄浆水培养基组分为:玉米黄浆水稀释比1∶4,蔗糖3.32 g/100 m L,CaCl₂0.3 g/100 m L,KH₂PO₄0.12 g/100 m L,Mg SO₄0.05 g/100 m L,柠檬酸0.2 g/100 m L,乙醇1.50 m L/100 m L,细菌纤维素产量达到1.11 g/100 m L,为优化前的1.63倍。结果表明经优化后黄浆水培养基能够满足Acetobacter xylinum生长代谢的需要,细菌纤维素产量得到显著提高;同时傅立叶红外光谱图和场发射扫描电镜图显示产物是纯度较高的纤维素,微观结构与椰果相似。      

塔河油田碳酸盐岩油藏定量化注水提高水驱效率现场应用与研究

塔河油田碳酸盐岩油藏具有埋藏深、非均质性强的特点,主要储集空间以溶孔、溶洞和裂缝为主,裂缝为主要渗流通道。随着油田能量的递减,注水做为补充能量最经济有效的方式得到大力推广。根据物质平衡原理,依托酸压曲线、注水指示曲线、能量指示曲线,对注水进行定量化计算,精细注水,明确注采关系,优化注采参数,推动油田提高水驱效率和采收率。     

面向敏捷制造的可视化资源计划系统

从以下两方面体现了敏捷制造资源计划的可视化含义:通过对敏捷制造资源计划系统的内涵分析,构建了资源计划实体关联模型,使制造网络资源达到组织有序;通过引入无线射频识别技术获取生产实时信息,提升实体关联模型的可应用性,解决计划与执行的脱节问题.     

装配式桥梁的应用前景分析

为克服传统桥梁建造模式存在的弊病,促进装配式桥梁发展,本文首先通过与传统建桥方法进行比较,分析了装配式桥梁的优点,特别是在建造速度快、建设质量高、交通影响小、节能环保优等方面具有优势;其次,阐述了装配式钢筋混凝土箱梁、钢箱梁、钢-混凝土组合结构、预制桥面板等上部结构拼装,以及装配式桥梁墩柱、桥台等下部结构拼装的发展现状...     

Tuning the pinning direction of giant magnetoresistive sensor by post annealing process

The Internet of Things has created an increasing demand for giant magnetoresistive (GMR)sensor owing to its high sensitivity,low power-consumption and small siz...     

自有冰雪照云寰——2022年冬奥会北京赛区场馆小记

介绍北京赛区所有场馆的基本情况,并重点描述遗产再利用、首钢园区复兴以及冰上场馆制冷系统的环保性等内容.北京赛区肩负2022年冬奥会赛事总体指挥、统筹调度的重要使命,其场馆建设在2008年奥运会遗产再利用、城市现有设施再利用、工业遗产复兴发展、冰上场馆制冷系统环保可持续、雪上场馆中国文化传承等方面,做出了诸多示范.     

Determination of the embedded electronic states at nanoscale interface via surface-sensitive photoemission spectroscopy

The fabrication of small-scale electronics usually involves the integration of different functional materials. The electronic states at the nanoscale interface ...     

全氢罩式退火炉退火热过程的研究(Ⅱ)——对流换热系数和钢卷径向等效导热系数的分析

介绍影响全氢罩式退火炉内换热的两个重要参数——对流换热系数和钢卷径向等效导热系数,详尽分析了两个参数的影响因素,并对比了氮气和氢气气氛下两参数的不同,从而在机理上阐明了全氢罩式炉相对传统混氢罩式炉的优越性,为优化炉内换热提供了理论的依据.     

A Novel Human Antibody,HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method

Fully human antibodies have minimal immunogenicity and safety profiles. At present, most potential antibody drugs in clinical trials are humanized or fully human. Human antibodies are mostly generated using the phage display method (in vitro) or by transgenic mice (in vivo); other methods include B lymphocyte immortalization, human–human hybridoma, and single-cell polymerase chain reaction. Here, we describe a structure-based computer-aided de novo design technology for human antibody generation. Based on the complex structure of human epidermal growth factor receptor 2 (HER2)/Herceptin, we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin. Next, these peptides were set as complementarity determining regions in a suitable immunoglobulin frame, giving birth to a novel anti-HER2 antibody named “HF,” which possessed higher affinity and more effective anti-tumor activity than Herceptin. Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases, such as cancer and infectious diseases.