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排序方式: 共有151条查询结果,搜索用时 15 毫秒
1.
H Lindemann 《Canadian Metallurgical Quarterly》1993,141(5):392-394
The defective regulation of the secretory chloride channel and the accelerated rate of sodium absorption in the airway epithelia of patients with cystic fibrosis (CF) contribute to the dehydration of airway secretions which is responsible for secondary damage in the respiratory tract. The sodium-blocker amiloride inhibits sodium absorption depending on the dosage of the drug. This effect is documented by means of measuring transepithelial potential difference which is decreased following to inhalative amiloride administration in CF patients. Clinical long term efficiency has been shown to be probable, but has to be confirmed. Investigation in this field is difficult, because there are some other important factors which influence viscosity of mucus. The use of amiloride can best be evaluated, if it is given immediately after birth. However, the answer to some important questions has to be found before. 相似文献
2.
Eutectic compositions of Al2O3 and ZrO2 have been melted and rapidly solidified by shock-wave quenching, flame-pressure atomization and high-pressure water atomization. Quenching rates > 104 K/s resulted in amorphous particles which, on annealing, crystallized at 1310°C. Microcrystalline particles with tetragonal ZrO2 distributed in an ?-Al2O3 matrix formed at lower quenching rates. ?-Al2O3 transformed into α-Al2O3 on annealing at 953°C. 相似文献
3.
Building the IBM 4758 secure coprocessor 总被引:1,自引:0,他引:1
Meeting the challenge of building a user-configurable secure coprocessor provided several lessons in hardware and software development and continues to spur further research. In developing the 4758, we met our major research security goals and provided the following features: (1) a lifetime-secure tamper-responding device, rather than one that is secure only between resets that deployment-specific security officers perform; (2) a secure booting process in which each layer progressively validates the next less-trusted layer, with hardware restricting access to its secrets before passing control to that layer; (3) an actual manufacturable product - a nontrivial accomplishment considering that we designed the device so that it does not have a personality until configured in the field; (4) the first FIPS 140-1 Level 4 validation, arguably the only general-purpose computational platform validated at this level so far; and (5) a multipurpose programmable device based on a 99-MHz 486 CPU internal environment, with a real operating system, a C language development environment and relatively high-speed cryptography 相似文献
4.
The analysis of a bimaterial medium with various notch opening angles has been carried out using boundary finite element method (BFEM) under arbitrary loading conditions. Introduced as novel method for stress concentration problems at geometrical discontinuities, cracks, bimaterial notches etc., the BFEM has been proved as numerically highly efficient. This has become more and more important because wedge type construction creates stress concentrations which may lead to crack initiation in many practical situations where multi-layered composite material is used, e.g. within aerospace, ship or automobile structures. So, the computational prediction of potential directions for crack initiation is essential for the knowledge of weak regions. All the analysis results are based on the hypothesis of Erdogan and Sih and have been verified by the well established finite element method. Results for potential crack initiation angles of both homogeneous and bimaterial media are presented with multiple examples of different wedge angles and different loading combinations. 相似文献
5.
Provides a detailed account of a joint meeting (November 4, 1967) of the Oregon Psychological Association and the Oregon District Branch of the American Psychiatric Association as a model for others who might attempt to bring such organizations into constructive interaction. Aspects of planning, committee meetings, organizational resources, registration, and programs are described. Feedback has been uniformly positive from both professional groups. There have already been gestures toward further cooperative action, such as the suggested establishment of collaborating committees on social issues or joint sponsorship of workshops. Underlying this constructive movement appears to be the large amount of positive interaction that took place among individuals at the meeting, the sense of mutual commitment created by the panels, and the erosion of some aspects of the negative organizational stereotypes. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Stephan Krenek Klaus Anhalt André Lindemann Christian Monte Jörg Hollandt Jürgen Hartmann 《International Journal of Thermophysics》2010,31(4-5):998-1010
The laser-flash method is a fast, widely used and well established technique to measure the thermal diffusivity. Since its introduction in the 1960s, it was proposed to expand this technique to the measurement of heat capacity and emissivity. Currently, the measurement of spectral emissivity at high temperatures is connected with relatively large uncertainties, although the spectral emissivity is an essential parameter for applications, e.g., in the lamp industry and fusion research. In this work, a theoretical study is presented on the possibility of emissivity measurements using the laser-flash method. Two mathematical approaches are discussed which solve the problem, that a measured temperature rise—necessary to calculate the emissivity—itself depends on the emissivity. It is shown that both methods have a negligible arithmetic error, making them applicable to be used in future work. 相似文献
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NJ Meropol M Porter LE Blumenson MJ Lindemann RP Perez L Vaickus GM Loewen PJ Creaven KA Wilkes MA Giedlin MA Caligiuri 《Canadian Metallurgical Quarterly》1996,2(4):669-677
We aimed to determine the toxicity and immunological effects of daily s.c. administered low-dose interleukin (IL) 2. Adult cancer patients received a single daily s.c. injection of IL-2 as outpatients for 90 consecutive days. Cohorts of four to nine patients were treated at escalating IL-2 dose levels until the maximum tolerated dose (MTD) was defined. Peripheral blood mononuclear cell phenotyping, IL-2 serum levels, and the presence of anti-IL-2 antibodies were investigated. Thirty-eight patients were treated at seven IL-2 dose levels ranging from 0.4 to 1.75 million International Units (mIU)/m2 daily. The MTD was 1.25 mIU/m2, with constitutional side effects, vomiting, and hyperglycemia dose limiting. Severe toxicity did not occur at or below the MTD, although mild local skin reaction and mild constitutional side effects were common. Objective tumor regressions were not observed during this Phase I trial. Low-dose IL-2 resulted in natural killer (NK) cell (CD3(-) CD56(+)) expansion at all dose levels. This effect was dose dependent (P < 0.01), ranging from a 154 to 530% increase over baseline. Peak NK levels were achieved at 6-8 weeks and sustained through 12 weeks of therapy. As predicted by in vitro studies of IL-2 receptor structure-activity relationships, the subset of NK cells that constitutively express high-affinity IL-2 receptors (CD3(-)CD56(bright+)) showed more profound dose-dependent expansion, with increases ranging from 368 to 2763% (P = 0.015). NK expansion occurred at peak IL-2 levels <10 pM (2.3 IU/ml). Three patients developed nonneutralizing anti-IL-2 antibodies. Thus, we concluded that selective expansion of NK cells may be achieved in vivo with daily s.c. injections of low-dose IL-2 with minimal toxicity. 相似文献