Estimating confidence intervals for cost-effectiveness ratios: an example from a randomized trial

Cost-effectiveness ratios usually appear as point estimates without confidence intervals, since the numerator and denominator are both stochastic and one cannot estimate the variance of the estimator exactly. The recent literature, however, stresses the importance of presenting confidence intervals for cost-effectiveness ratios in the analysis of health care programmes. This paper compares the use of several methods to obtain confidence intervals for the cost-effectiveness of a randomized intervention to increase the use of Medicaid's Early and Periodic Screening, Diagnosis and Treatment (EPSDT) programme. Comparisons of the intervals show that methods that account for skewness in the distribution of the ratio estimator may be substantially preferable in practice to methods that assume the cost-effectiveness ratio estimator is normally distributed. We show that non-parametric bootstrap methods that are mathematically less complex but computationally more rigorous result in confidence intervals that are similar to the intervals from a parametric method that adjusts for skewness in the distribution of the ratio. The analyses also show that the modest sample sizes needed to detect statistically significant effects in a randomized trial may result in confidence intervals for estimates of cost-effectiveness that are much wider than the boundaries obtained from deterministic sensitivity analyses.     

2007年1-10月主要钢铁产品进出口形势分析

2007年1-10月,我国的粗钢产量达到4.09亿吨,同比增长18.14%。10月单月产量4292.2万吨,再创单月产量新高;1-10月,钢材产量达4.67亿吨(含重复材),同比增长23.53%,10月钢材产量     

砂浆立方体抗压强度与底模的关系

建筑砂浆试件的制作目前均执行《建筑砂浆基本性能试验方法》(JGJ70-1990)有关规定，所用底模系含水量不大于2％的普通粘土砖。     

Scattering center parameterization of wide-angle backscattered datausing adaptive Gaussian representation

We present a scattering center extraction algorithm to parameterize the backscattered data from complex targets collected over large angular apertures. This parameterization is based on a scattering center model of the target, but includes an aspect-dependent amplitude function for each scattering center. A two-dimensional (2-D) adaptive Gaussian representation (AGR) algorithm is used to extract the position and the amplitude function associated with each scattering center. The algorithm is tested with data generated by the Xpatch radar simulation code as well as chamber measurement data. The results show that a very good compression ratio can be achieved, resulting in a compact scattering center model of the target. Once such model is available, we can easily reconstruct range profiles and ISAR images at any aspect on the same plane with good accuracy     

Spontaneous mutation for a quantitative trait in Drosophila melanogaster. II. Distribution of mutant effects on the trait and fitness

Exposure of the Chinese hamster ovarian AuxB1 cell line in vitro to fractionated X-irradiation generated sublines designated DXR-10, which proved resistant to multiple drugs and overexpressed P-glycoprotein (Pgp), as judged by Western blotting using the C219 monoclonal antibody. Further characterization of these irradiated DXR-10 sublines has provided evidence for: (i) the expression of cross-resistance to gramacidin D, taxol, puromycin and Navelbine, but not to daunomycin or mitoxantrone; (ii) overexpression of the class I Pgp, as judged by Western blotting using the C494 monoclonal antibody; (iii) decreased accumulation of 3H-vincristine, which could be enhanced by verapamil addition; (iv) unaltered accumulation and subcellular distribution of adriamycin; (v) significantly increased rhodamine 123 accumulation in the presence of verapamil; (vi) plasma-membrane ultrastructural modifications resulting in a significantly increased surface area; (vii) numerous clonal karyotypic alterations, with abnormalities involving the long arm of chromosome 1 being consistently identified; (viii) a lack of overexpression of sorcin; (ix) increased total glutathione levels and overexpression of glutathione S-transferase pi. The fact that only certain of these features are considered characteristic of the 'classic' multidrug-resistant CHRC5 cell line supports our earlier proposal that exposure to fractionated X-irradiation results in the expression of a unique drug-resistance phenotype.     

Cytoskeletal changes during neurogenesis in cultures of avain neural crest cells

Neural crest cells are motile and mitotic, whereas their neuronal derivatives are terminally post-mitotic and consist of stationary cell body from which processes grow. The present study documents changes in the cytoskeleton that occur during neurogenesis in cultures of avain neural crest cells. The undifferentiated neural crest cells contain dense bundles of actin filaments throughout their cytoplasm, and a splayed array of microtubules attached to the centrosome. In newly differentiating neurons, the actin bundles are disrupted and most of the remaining actin filaments are reorganized into a cortical layer underlying the plasma membrane of the cell body and processes. Microtubules are more abundant in newly-differentiating neurons than in the undifferentiated cells, and individual microtubules can be seen dissociated from the centrosome. Neuron-specific beta-III tubulin appears in some crest cells prior to cessation of motility and cell division, and expression increases with total microtubule levels during neurogenesis. To investigate how these early cytoskeletal changes might contribute to alterations in morphology during neurogenesis, we have disrupted the cytoskeleton with pharmacologic agents. Microfilament disruption by cytochalasin immediately arrests the movement of neural crest cells and causes them to round-up, but does not significantly change the morphology of the immature neurons. Microtubule depolymerization by nocodazole slows the movement of undifferentiated cells and causes retraction of processes extended by the immature neurons. These results suggest that changes in the actin and microtubule arrays within neural crest cells govern distinct aspects of their morphogenesis into neurons.     

先进的控制室报警系统研究

先进的报警系统是核电厂先进的控制室中重要的系统之一，阐述了核电厂先进的报警系统的重要性、功能和特点，并且比较详细地论述了报警信号的处理方法和显示方式。     

交流变频钻井泵试验台的研制

针对大功率、超高压（52MPa）钻井泵的试验问题，设计了采用交流变频控制技术，提高试验能力的试验台架。该试验台架体现了实用性、可操作性、高效节能、环保性；电气传动部分采用具有国际先进水平、成熟技术的交流变频调速系统，实现无级调速；机械传动部分采用单级双速变速箱，试验范围广；电控系统可完成对钻井泵各种参数在线监控和测定。