Research in Copenhagen hospitals--a bibliometric evaluation

The aim of this study was to measure size and quality of the research carried out in Copenhagen (H:S) hospitals using conventional bibliometry. Based on the H:S-report on scientific publications in 1995, the research performed in each hospital and each department has been measured as the sum of publications and as journal impact factor score. Publication numbers and impact factor score varied eighty-fold between the individual H:S-hospitals. With a close relation between publication numbers and impact factor score, the Rigshospital produced 60%, Hvidovre Hospital 20% and Bispebjerg Hospital 11%, while the four remaining hospitals (Frederiksberg Hospital, the Copenhagen Community Hospital, Sct. Hans Hospital and Sundby Hospital) together produced 9% of the research. The departmental research activities as such showed correlation neither to clinical specialty nor to specific hospitals. In conclusion, the Rigshospital is responsible for most of the research in H:S. Generally, departments headed by university professors showed the highest research activity.     

Results of cemented metal-backed acetabular components: a 10-year-average follow-up study

We have developed a computer program for the rapid assessment of the primary structure differences between a protein of unknown sequence and a homologous known protein. Both proteins are reduced, alkylated, and digested with the same hydrolytic agent. The unfractionated peptide mixtures are submitted to automatic sequence analysis. Based on the knowledge of the reference sequence, the program utilizes the analysis data to identify all the potential peptides present in the two mixtures, determining their primary structure, homology degree, and molecular weight calculated both as integer MH+ and average mass variables. These fingerprints allow the user to easily identify the structural differences between the two proteins and clarify possible doubts by a mass spectrometric analysis of the two mixtures. In order to verify the utility of the program, we provide an application example using the already reported data of two homologous proteins.