Glucagon therapy in the treatment of symptomatic bradycardia

Symptomatic bradycardia is commonly seen in the emergency department. Effective drug therapy for this clinical scenario is limited. Although glucagon has been used in no clinical trial in this setting, its cardiac activity may prove useful, particularly in the setting of beta-adrenergic blockade. We report a case series comprising three patients taking maintenance beta-blocker therapy who presented to the ED with symptomatic bradycardia and hypotension and in whom glucagon therapy obviated the need for further treatment. Further study is warranted to evaluate and define the role of glucagon in the treatment of symptomatic bradycardia.     

Simulations of amphiphilic fluids using mesoscale lattice-Boltzmann and lattice-gas methods

We compare two recently developed mesoscale models of binary immiscible and ternary amphiphilic fluids. We describe and compare the algorithms in detail and discuss their stability properties. The simulation results for the cases of self-assembly of ternary droplet phases and binary water-amphiphile sponge phases are compared and discussed. Both models require parallel implementation and deployment on large scale parallel computing resources in order to achieve reasonable simulation times for three-dimensional models. The parallelization strategies and performance on two distinct parallel architectures are compared and discussed. Large scale three-dimensional simulation of multiphase fluids requires the extensive use of high performance visualization techniques in order to enable the large quantities of complex data to be interpreted. We report on our experiences with two commercial visualization products: AVS and VTK. We also discuss the application and use of novel computational steering techniques for the more efficient utilization of high performance computing resources. We close the paper with some suggestions for the future development of both models.     

Spot size, adiabaticity and diffraction in tapered fibres

A simple formula is given for the maximum spot size achievable by downtapering a single-mode fibre, regardless of core profile. When the fundamental-mode field is approximately Gaussian, the maximum taper angle associated with minimal loss of spot-size power on a finite-length taper is the classical diffraction angle for a beam passing through a circular aperture.     

First year serologic response to treatment for syphilis: a model for prediction of seroreversion

There is no straightforward test available, within weeks of treatment for syphilis, to assess adequacy of serologic response. We propose a method to predict non-treponemal seroreversion based on short term response. To develop and illustrate this method, we used data from 370 individuals with infectious syphilis. Individual serologic response appears to be a linear function of (log) time, suggesting the possibility of using rapid plasma reagin titres recorded in the first few months after treatment to determine the slope of the linear treatment response line. The slope of the response line, during the first year after treatment, is an important predictor of seroreversion but must be considered in conjunction with pre-treatment titre. We recommend development of an action line be developed based on these variables. Such a line would indicate the necessity for retreatment if the line plotted from the patient's first year response failed to fall below the action line.     

Application of probability techniques to the objective interpretation of veterinary clinical biochemistry data

Methods for the interpretation of veterinary clinical biochemistry have not developed as rapidly as biochemical technology. However, the results of clinical biochemistry tests are only of value when they are interpreted appropriately. A retrospective study was undertaken to investigate the equine biochemistry data which had been stored in a veterinary hospital database. By applying percentile analysis and Bayesian probability methods to the clinical biochemistry and corresponding diagnosis data, a novel method for the interpretation of clinical biochemistry data has been developed. The method allows clinicians to determine whether a biochemistry value is abnormal, its degree of abnormality, and the most likely associated diagnoses. The method could be used to investigate a practice-based population and may have significant implications for the interpretation of clinical biochemistry data in veterinary medicine in the future.     

Linear-spline approximation for semi-parametric modeling of failuredata with proportional hazards

Modeling of failure processes using proportional hazards involves estimating both a baseline failure intensity as well as the parameters of the proportional failure intensity. In the absence of any information regarding the baseline failure intensity, a nonparametric form is typically assumed. This paper proposes a linear-spline function to approximate this baseline failure intensity, and develops such a spline function appropriate to bad-as-old failure data generated from a repairable system. Field data from an industrial setting demonstrate an improved approximation using such a spline function as compared to other procedures in the literature     

Diversity performance of precoded orthogonal space-time block codes using limited feedback

Orthogonal space-time block codes (OSTBCs) are simple space-time codes that can be used for open-loop transmit diversity systems. OSTBCs, however, can only be designed for certain numbers of transmit antennas. Channel-dependent linear precoders have been proposed to overcome this deficiency, but it is not clear what conditions the precoder design must satisfy to guarantee full diversity order. In this letter, we show necessary and sufficient conditions for linear precoded OSTBCs to provide full diversity order. We show that limited feedback precoding can achieve full diversity order using fewer bits than limited feedback beamforming. We also present a simplified version of antenna subset selection for OSTBCs that can provide full diversity order with low complexity and only a small amount of feedback.     

The crystal structure of {alpha}-bungarotoxin at 2.5 ? resolution: relation to solution structure and binding to acetylcholine receptor

We report collection of 2.5 ? resolution X-ray diffraction datafrom newly grown crystals of the rare ‘small unit cell’form of the long snake neurotoxin, -bungarotoxin. The previousmodel of the molecule has been rebuilt, and refined using least-squaremethods to a crystallographic residual of 0.24 at 2.5 ? resolution.-Bungarotoxin's crystal structure is compared with the crystalstructures of two other snake neurotoxins (cobratoxin and erabutoxin),and with its solution structure inferred from spectroscopicstudies. Significant differences include less ß-sheetin bungarotoxm's crystal structure than in solution, or in thecrystal structures of other neurotoxins, and an unusual orientationin the crystal of the invariant tryptophan. The functional,binding surface of bungarotoxin is described; it consists primarilyof hydrophobic and hydrogen-bonding groups and only a few chargedside chains. The structure is compared with experimental bindingparameters for neurotoxins.     

Numerical quadrature used for radiative heat-transfer computations

Physical reasoning makes it possible to use artificial parameters with numerical quadrature in order to obtain approximate solutions for the Fredholm integral equations associated with radiative heat transfer calculations. With the aid of such parameters, decisions can be made concerning the applicability and usefulness of the numerical quadrature technique.