Biological Effects of 25 to 150 GHz Radiation After In Vitro Exposure of Human Fibroblasts: a Comparison of Experimental Results

In this paper, we present a comprehensive discussion of the results obtained after in vitro exposure of human fetal fibroblasts and human adult fibroblasts to pulsed radiation in a wide band between 100 and 150 GHz and to continuous wave radiation at 25 GHz. In order to assess potential effects of exposure, the genome integrity, cell cycle, cytological ultrastructure, and proteins expression were evaluated.     

A new mesh-growing algorithm for fast surface reconstruction

This paper presents a new high-performance method for triangular mesh generation based on a mesh-growing approach. Starting from a seed triangle, the algorithm grows the triangular mesh by selecting a new point based on the Gabriel 2—Simplex criterion. This criterion can be considered to be a good approximation of the 2D Delaunay if the point cloud is well-sampled and not too rough. The performance of the proposed method is compared with that of the Cocone family and that of Ball Pivoting as regards the tessellation rate and the quality of the surface being generated from some benchmark point clouds and artificially noised test cases. The results are analysed and critically discussed.     

Effect of Surface Texture on the Adhesion Performance of Laser Treated Ti6Al4V Alloy

The growing demand in lighter and safer structures generates the requirement of lighter joining strategies, particularly for lightweight metal alloys, composites, and also joining dissimilar materials together. Titanium alloys stand out as the conventional choice for materials for light weight structures. Adhesive bonding of titanium is an appealing route for joint design, also for the possibility of joining it with dissimilar materials. The realization of a strong joint depends not only on the joint design and type of adhesive, but also on the preparation of the adhering surface. Laser texturing presents advantages compared to common surface preparation processes in terms of eco-compatibility, energetic efficiency, ease of manufacturing, and repeatability. This work presents a preliminary investigation on laser texturing of Ti6Al4 V alloy with a pulsed fiber laser source with the aim to increase surface adhesion for bonding. Particularly, different surface textures are proposed, and laser machining strategies are developed. The results showed that laser texturing provided up to eightfold and 30% higher shear strength compared to plain and sand blasted surfaces, respectively. Failure analysis showed that a margin of improvement is still possible by adapting the surface texture for better cavity filling and reducing surface damage caused by the laser treatment.     

Low-power DSP system for real-time correction of fish-eye cameras in automotive driver assistance applications

The development of an embedded system for real-time correction of fish-eye effect is presented. The fish-eye lens is applied to driver assistance video systems because of its wide-angled view. A large field of view can reduce the number of cameras needed for video system and their cost, installation, maintenance and wiring issues. On the other hand, this lens causes inherent radial distortion to image that has to be corrected in real-time with a low-cost and low-power processing platform. This paper proposes a solution that can be easily adapted to different types of lens and camera, and meets real-time constraints with a power budget within 100 mW and a board size of few cm². Starting from mathematical equations, given by the geometrical optics, a state-of-the-art correction method is presented, then optimizations are introduced at different levels: algorithmic level, where a real-time correction parameter calculation avoids extra non-volatile off-chip memory cards; data transfer level, where a new pixel pair management reduces memory access and storage burden; HW-SW implementation level, where a low-power board has been developed and tested in real automotive scenarios. Other applications of the developed system, such as multi-camera and multi-dimensional video systems, are finally presented.     

Modelling of back tempering in laser hardening

Back tempering is one of the most critical problems in laser hardening of extended surfaces. In this type of treatment, several laser tracks are slightly overlapped to obtain a uniform hardened surface. Due to the overlapping, tempered zones are generated on the treated surface with the consequent lack of uniformity in the surface hardness. In this work, a regression model was developed to estimate the loss of hardness due to the tempering effect as a function of the thermal cycle. A specific test, named laser surface treatment test, was designed and executed to reproduce the hardness reduction due to the tempering effect. An analytical thermal model was developed to evaluate the thermal cycle undergone by the material during this test. By the results of the laser surface treatment test combined with the analytical model, a prediction model was estimated. Good agreement was found between predicted and measured hardness decrease, and the identified model could be integrated in a numerical code to evaluate the optimal process parameters.     

Electrochemical repair techniques in carbonated concrete. Part II: cathodic protection

The role of several factors such as concrete composition, exposure condition and pre-corrosion of steel reinforcement in concrete on the effectiveness of the electrochemical realkalisation (ER) technique was discussed in Part I of this article (Bertolini and Redaelli in J Appl Electrochem, doi:, 2011). Here the same factors will be considered in the case of cathodic protection (CP). CP differs from ER since it is a permanent technique with much lower applied current density. It was originally introduced to protect steel from corrosion in chloride-contaminated concrete; however, it can be advantageous even in carbonated concrete, in particular compared to conventional repair. CP tests were carried out on reinforced specimens made with six different types of concrete, subjected to accelerated carbonation. CP was applied with a current density of 10 mA m⁻² of steel preceded by a start-up current density of 100 mA m⁻² for 3 weeks. Reference specimens in the same conditions were also considered.     

Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine

Primary plasma cell leukemia (pPCL) is a rare and aggressive variant of multiple myeloma (MM) which may represent a valid model for high-risk MM. This disease is associated with a very poor prognosis, and unfortunately, it has not significantly improved during the last three decades. New high-throughput technologies have allowed a better understanding of the molecular basis of this disease and moved toward risk stratification, providing insights for targeted therapy studies. This knowledge, added to the pharmacogenetic profile of new and old agents in the analysis of efficacy and safety, could contribute to help clinical decisions move toward a precision medicine and a better clinical outcome for these patients. In this review, we describe the available literature concerning the genomic characterization and pharmacogenetics of plasma cell leukemia (PCL).