Constraints of fossil fuels depletion on global warming projections

A scientific debate is in progress about the intersection of climate change with the new field of fossil fuels depletion geology. Here, new projections of atmospheric CO₂ concentration and global-mean temperature change are presented, should fossil fuels be exploited at a rate limited by geological availability only. The present work starts from the projections of fossil energy use, as obtained from ten independent sources. From such projections an upper bound, a lower bound and an ensemble mean profile for fossil CO₂ emissions until 2200 are derived. Using the coupled gas–cycle/climate model MAGICC, the corresponding climatic projections out to 2200 are obtained. We find that CO₂ concentration might increase up to about 480 ppm (445–540 ppm), while the global-mean temperature increase w.r.t. 2000 might reach 1.2 °C (0.9–1.6 °C). However, future improvements of fossil fuels recovery and discoveries of new resources might lead to higher emissions; hence our climatic projections are likely to be underestimated. In the absence of actions of emissions reduction, a level of dangerous anthropogenic interference with the climate system might be already experienced toward the middle of the 21st century, despite the constraints imposed by the exhaustion of fossil fuels.     

Coping strategies and collective efficacy as mediators between stress appraisal and quality of life among rescue workers.

Fire-fighters, paramedics, and emergency medical technicians routinely confront potentially traumatic events in the course of their jobs. The mediation role of coping strategies and collective efficacy in the relationship between stress appraisal and quality of life was examined (compassion satisfaction, compassion fatigue, and burnout) in a correlational study. Participants were 463 Italian rescue workers (fire fighters and different categories of emergency health care professionals). Participants filled out measures of stress appraisal, collective efficacy, coping strategies, and quality of life. The results showed that emotion and support coping, self-blame coping, and self-distraction mediated the relationship between stress appraisal and compassion fatigue. Moreover, collective efficacy, self-blame coping, and religious coping mediated the relationship between stress appraisal and burnout. Finally, collective efficacy, self-blame coping, and problem-focused coping mediated the relationship between stress appraisal and compassion satisfaction. Cognitive restructuring and denial did not mediate the relation between stress appraisal and any of the quality of life dimensions. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Complete and ready simulation semantics are not finitely based over BCCSP, even with a singleton alphabet

This note shows that the complete and the ready simulation preorders do not have a finite inequational basis over the language BCCSP when the set of actions is a singleton. Moreover, the equivalences induced by those preorders do not have a finite (in)equational axiomatization either. These results are in contrast with a claim of finite axiomatizability for those semantics in the literature, which was based on the erroneous assumption that they coincide with complete trace semantics in the presence of a singleton set of actions.     

Minimum Hellinger distance based inference for scalar skew-normal and skew-t distributions

The skew-normal is a parametric model that extends the normal family by the addition of a shape parameter to account for skewness. As well, the skew-t distribution is generated by a perturbation of symmetry of the basic Student’s t density. These families share some nice properties. In particular, they allow a continuous variation through different degrees of asymmetry and, in the case of the skew-t, tail thickness, but still retain relevant features of the perturbed symmetric densities. In both models, a problem occurs in the estimation of the skewness parameter: for small and moderate sample sizes, the maximum likelihood method gives rise to an infinite estimate with positive probability, even when the sample skewness is not too large. To get around this phenomenon, we consider the minimum Hellinger distance estimation technique as an alternative to maximum likelihood. The method always leads to a finite estimate of the shape parameter. Furthermore, the procedure is asymptotically efficient under the assumed model and allows for testing hypothesis and setting confidence regions in a standard fashion.     

Response dynamics of phosphorelays suggest their potential utility in cell signalling

Phosphorelays are extended two-component signalling systems found in diverse bacteria, lower eukaryotes and plants. Only few of these systems are characterized, and we still lack a full understanding of their signalling abilities. Here, we aim to achieve a global understanding of phosphorelay signalling and its dynamical properties. We develop a generic model, allowing us to systematically analyse response dynamics under different assumptions. Using this model, we find that the steady-state concentration of phosphorylated protein at the final layer of a phosphorelay is a linearly increasing, but eventually saturating function of the input. In contrast, the intermediate layers can display ultrasensitivity. We find that such ultrasensitivity is a direct result of the phosphorelay biochemistry; shuttling of a single phosphate group from the first to the last layer. The response dynamics of the phosphorelay results in tolerance of cross-talk, especially when it occurs as cross-deactivation. Further, it leads to a high signal-to-noise ratio for the final layer. We find that a relay length of four, which is most commonly observed, acts as a saturating point for these dynamic properties. These findings suggest that phosphorelays could act as a mechanism to reduce noise and effects of cross-talk on the final layer of the relay and enforce its input–response relation to be linear. In addition, our analysis suggests that middle layers of phosphorelays could embed thresholds. We discuss the consequence of these findings in relation to why cells might use phosphorelays along with enzymatic kinase cascades.     

Characterization, modeling and assessment of Roll-N-Cage isolator using the cable-stayed bridge benchmark

This paper presents the results of an extensive series of simulation tests to identify the mechanical characteristics of an innovative isolation device known as the Roll-N-Cage (RNC) isolator. The seismic performance of an RNC passive control scheme is subsequently investigated on a model of the cable-stayed bridge benchmark. Starting from different configurations studied in the laboratory for a 1/10 reduced-scale prototype, the RNC isolator stiffness and damping properties are investigated in terms of cyclic tests with different parameters. Tests at the ultimate level state consisting of monotonic shear and axial loading have been also carried out as a part of the qualification process. The goal of this study is twofold: first, to examine the main integrated mechanisms of the RNC isolator through sophisticated 3D finite element simulation models using a multi-purpose finite element code. The main result of this step is to attempt modeling the force–displacement relationship using the standard Bouc–Wen model of smooth hysteresis. The second aim of this study is the numerical assessment of the device efficiency through its implementation into a bridge model considering several ground motions as external excitations. Based on these extensive studies, it was found that the RNC isolator is promising as a reliable isotropic horizontal isolation device for bridge structures.     

PEGylated chitosan derivatives: Synthesis, characterizations and pharmaceutical applications

This review sets out to describe and discuss the synthetic approaches and the fields of application of PEGylated chitosan copolymers especially for medical use. The PEGylation of chitosan and chitosan derivatives is able to add new physicochemical properties to the cationic polysaccharide polymers, thereby overcoming some limitations, especially regarding their solubility and their use in drug and gene delivery (DNA and siRNA). All methods of derivatization have been considered and described together with the different methods of characterization of the copolymers. The capacities of PEGylated chitosan to reduce chitosan toxicity, to enhance membrane permeation and to form thermosensitive hydrogels have also been discussed.     

Corrosion behaviour of sol–gel treated and painted AA2024 aluminium alloy

Design, development and scale-up of environmentally friendly coatings are very important in order to replace chromate based coatings for aluminium alloys. Barrier properties, paint adhesion and possibly self-healing ability are relevant aspects for replacement of chromate-based pre-treatments. Sol–gel materials are candidates for use in protective coating applications, as it is possible to form highly adherent and chemically inert oxide films on metal substrates.     

Temperature and storage effects on antioxidant activity of juice from red and white grapes

The effect of temperature and storage time on the phenolic composition and on the antioxidant activity of grape (Vitis vinifera L.) juices made using a red (Sangiovese, SG) and a white (Muscat of Alexandria, MA) variety was studied. Total phenolics, flavonoids, flavan‐3‐ols and hydroxycinnamoyl‐tartrates (HCT) were determined on grape extracts (GE) and juices. Total anthocyanins and anthocyanins composition were measured on GE. The antioxidant activity was assessed by means of two different in vitro tests: scavenging of the stable 2,2‐diphenyl‐1‐picrylhydrazyl radical and the inhibition of tyrosine nitration mediated by authentic peroxynitrite (ONOO^?). All the juices were analysed after 24 h and 2 weeks of storage by means of two‐way anova (factors being cultivar and temperature). Anthocyanins were not detected in MA extract, whereas in SG their content was 534 mg malvidin‐equivalent per 100 g of dry matter (d.m.) and malvidin derivatives (glycosylated and coumaroylated) were the most represented (respectively 169 and 41 malvidin‐equivalent per 100 g of d.m.). HCT content of the extracts was higher in SG (overall +33%). Also in grape juices, HCT were lower in MA and in this variety, the trans‐fertaric and cis‐coutaric acids were also undetectable. Cultivar effect proved to be highly significant, while no significant differences in the phenolic composition were observed for storage temperatures (4 and ?20 °C) and cultivar × temperature interaction. However, when statistical analysis was focused on each cultivar, MA was found to be more sensible to storage conditions and a significant reduction in total phenolics (?20%) and flavonoids (?53%) content and in the ONOO^? scavenging potential (?32%) was evident after 2 weeks at 4 °C (when compared with the same storage temperature after 24 h). On the contrary, SG juices did not show significant differences among the four storage treatments investigated. These results could be explained suggesting that anthocyanins presence in red grape plays a key role in juice stability.     

Multi-Criteria Decision Making support system for pancreatic islet transplantation

Pancreatic islet transplantation consists of replacing insulin-producing cells to restore normal glycemia in diabetic patients. This is a minimal invasive procedure that has been proved successful. Unfortunately unpredictability of islet transplant outcome remains a frustrating and costly issue limiting the clinical implementation of this procedure. Multiple variables are involved in the procedure and assessment is subjective to individual operators. The aim of this study was to generate a system expressing the probability of transplant success in relation to four classes of identified variables (donor, organ, isolation and recipient). We have proposed the utilization of Multi-Criteria Decision Making methods (MCDM) as a powerful tool for evaluating pancreatic islet transplant-related information with the goal to achieve optimal decision. Technique Ordered Preference by Similarity to the Ideal Solution (TOPSIS), one of the most widely used MCDM methods in decision support systems, was here utilized with modification to fit better in a medical system. In our modified method, we have utilized fuzzy logic in order to consider uncertain and vague data.