PTSD transmission: A review of secondary traumatization in Holocaust survivor families.

Posttraumatic Stress Disorder (PTSD) provides a common language for diagnoses and assessment of trauma victims, including Holocaust survivors. Many of these survivors established post-war families and it is here that we began to witness the possibility of trauma transmission. Parental communication regarding the Holocaust, often characterized by obsessive re-telling or all-consuming silence, and strong family ties are implicated in the theoretical literature on trauma transmission. Terms such as vicarious, empathic, and secondary traumatization have been used to describe intergenerational trauma transmission. The crucial emergent question is whether a secondary PTSD syndrome, reflected in the current PTSD symptomology, is being transmitted from one generation to the next. There is evidence in the literature to support this hypothesis and a call is made for rigorous empirical studies as the test. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

DDC: Innovation in Manufacturing

DDC means direct digital control of manufacturing variables at the lowest level process regulation, but DDC can ``talk' to higher order systems and extend upwards in a computer hierarchy. DDC has been developed to a large degree by users and can be fitted to existing processes using standard available equipment and control concepts. No computer programming is necessary, reliability is higher than in some conventional systems, and maintenance is not difficult. Anyone now operating the plant can handle DDC. Costs can be lower than comparable function conventional controls, and there are only four major hardware components to a DDC system. The paper lists a number of real problems taken from the record which DDC has solved in existing successful installations. Methods for putting across a project and overcoming traditional management objections have been worked out.     

Green power in LA: Overcoming institutional barriers

Los Angeles, USA-based Utility company LADWP has embarked on an ambitious programme to fundamentally shift the utility's power sources away from fossil fuels such as coal and nuclear power towards cleaner generation. Lyn Corum, Refocus correspondent describes the ups and downs and current status of the Utility's project.     

maspin suppresses the invasive phenotype of human breast carcinoma

The recently discovered tumor suppressor gene maspin has been shown to inhibit tumor cell motility, invasion, and metastasis in breast cancer by our laboratories. Nonetheless, the exploitation of maspin as a potential diagnostic and/or therapeutic tool has remained limited due to the lack of knowledge concerning its molecular and biological mechanism(s) of action. The work reported here demonstrates that recombinant maspin (rMaspin) has the ability to induce higher cell surface levels of alpha5- and alpha3-containing integrins and reduced levels of alpha2-, alpha4-, alpha6-, alpha(v)-, and some beta1-containing integrins in the metastatic human breast carcinoma cell line MDA-MB-435 concomitant with its ability to inhibit the invasive process in vitro. Furthermore, treatment of MDA-MB-435 cells with rMaspin results in the selective adhesion of the cell to a fibronectin matrix and conversion from a fibroblastic to a more epithelial-like phenotype. In addition, the ability of rMaspin to inhibit the invasive process can be abrogated with a blocking antibody to the alpha5beta1 integrin, which diminishes the ability of the cells to invade through a fibronectin matrix-containing barrier in vitro. Taken together, these data address the hypothesis that rMaspin reduces the invasive phenotype of MDA-MB-435 cells by altering their integrin profile, particularly alpha5, which in turn converts these cells to a more benign epithelial phenotype, with less invasive ability. These data provide new insights into the biological significance of this tumor suppressor gene found in normal mammary epithelium and may form the basis of novel therapeutic strategies in the management of breast carcinoma.     

Attributional style and depressive symptoms among children.

The reformulation of helplessness theory proposes that an insidious attributional style accompanies and predisposes depressive symptoms. The present study investigated predictions of the reformulation among 96 8–13 yr olds who completed the Children's Attributional Style Questionnaire (ASQ) and Children's Depression Inventory twice, 6 mo apart. 83 of their parents completed the adult ASQ and the Beck Depression Inventory at their children's 2nd testing. Children who attributed bad events to internal, stable, and global causes were more likely to report depressive symptoms than were children who attributed these events to external, unstable, and specific causes. This depressive attributional style predicted depressive symptoms 6 mo later, suggesting that it may be a risk factor for depression. Children's attributional style for bad events and their depressive symptoms converged with those of their mothers but not their fathers. (15 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Depressive attributional style.

143 undergraduates completed an attributional style scale designed by the authors, the short form of the Beck Depression Inventory, and the Multiple Affect Adjective Check List. Results show that depressed Ss, compared to nondepressed Ss, attributed bad outcomes to internal, stable, and global causes, as measured by the attributional style scale. This attributional style was predicted by the reformulated helplessness model of depression. In addition, relative to nondepressed Ss, depressed Ss attributed good outcomes to external, unstable causes. (8 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A NOTE ON THE DISTRIBUTIONS OF NON-LINEAR AUTOREGRESSIVE STOCHASTIC MODELS

Abstract. It is shown that an ergodic stationary non-linear autoregressive stochastic process, perturbed by a white noise process with symmetric distributions, has symmetric stationary distributions if and only if the regression function is skew-symmetric. The implications of this observation are discussed.     

Heterogeneity of cognitive style among depressed inpatients.

An inference from the cognitive theories of depression is that only a subset of depressed individuals should exhibit distinctively negative cognitive styles. Although this inference has been supported by previous research, attempts to characterize these depressives have yielded few identifying variables. This study of psychiatric inpatients and normal control subjects identified several characteristics of depressives with very negative cognitive styles by (a) examining traditional depression subtypes, (b) grouping depressives on the basis of clinical observations, and (c) asking whether sex, developmental events, and history and severity of depression predict cognitive styles. We found that borderline personality disorder, negative family dynamics during childhood, a history of sexual abuse, and severity of depression predict cognitive styles. We speculate that aversive developmental events may contribute to cognitive vulnerability to depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)