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11.
裂尖力学状态是影响核电结构材料应力腐蚀开裂(SCC)扩展速率的主要因素之一。为了搞清SCC不同扩展阶段裂尖驱动力的变化及其对SCC扩展速率的影响,本文建立了SCC扩展不同阶段的有限元模型,详细分析了裂纹初始阶段影响裂尖应力状态的工作载荷、残余应力,以及氧化膜形成过程中产生的膜致应力。结果表明,在SCC裂纹初始阶段,裂尖氧化膜形成所产生的“锲入张力”是SCC的主要驱动力;随着裂纹的扩展,工作载荷和残余应力逐渐成为SCC裂纹扩展的主要驱动力。 相似文献
12.
研究冷轧后退火对Ti_(50)Ni_(48)Co_2形状记忆合金显微组织演化和超弹性性能的影响。结果表明,在冷轧制过程中,合金的显微组织经历了应力诱导马氏体相变和马氏体塑性变形、变形孪晶、马氏体中沿孪晶和不同晶界的位错堆积、纳米晶化、非晶化以及马氏体向奥氏体的可逆相变6个基本阶段。在400℃退火1 h后,冷轧样品中形成的非晶相完全晶化,生成了一个完全纳米晶体的结构。这种纳米晶体合金的峰应力高达730 MPa,明显高于粗晶Ni_(50)Ti_(50)和Ti_(50)Ni_(48)Co_2合金。而且,纳米晶Ti_(50)Ni_(48)Co_2合金具有较高的阻尼容量和较好的储能效率。 相似文献
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HABIB ABBASI MOHAMMAD EBRAHIMZADEH MOUSAVI MOHAMMAD REZA EHSANI ZAHRA EMAM d-JOMEA MOHARAM VAZIRI JAMSHID RAHIMI SOMAYEH AZIZNIA 《International Journal of Dairy Technology》2009,62(4):549-555
The effects of different cultures and incubation temperatures on the physical properties of low fat yoghurts were investigated. The samples were incubated with exopolysaccharide (EPS)-producing and non-EPS-producing cultures at 37, 42 and 45°C. All measured parameters except firmness were influenced by culture type and incubation temperature. Firmness, G' and G" were maximised at 42°C for both cultures. Increased incubation temperature and EPS culture led to a higher water-holding capacity but lower syneresis, G' and G". The EPS treatment incubated at 37°C showed even lower syneresis than non-EPS treatments incubated at higher temperatures. 相似文献
17.
JAVAD ALIAKBARLU MOHAMMAD ALIZADEH SEYED MEHDI RAZAVI‐ROHANI NASER AGH 《International Journal of Dairy Technology》2011,64(3):417-424
The simultaneous effects of processing factors such as ripening time (25–75 days), ripening temperature (4–14 °C) and brine concentration (10–13%) on biogenic amines content, proteolysis and sensory score of Iranian white brine cheese were studied, in 12 cheeses. Response surface methodology (RSM) was used to minimise biogenic amines content. At low level of ripening time, biogenic amines content decreased with increasing levels of brine concentration but at high level of ripening time, brine concentration had inverse effect. Ripening time showed quadratic effect on biogenic amines content. Based on biogenic amines content and sensory score, the optimum conditions were 13% brine and ripening at 9–14 °C for 43–65 days. 相似文献
18.
MASOUMEH OGHABI AVA SAFAROGHLI-AZAR ATIEH POURBAGHERI-SIGAROODI MOHAMMAD SAYYADI MOHSEN HAMIDPOUR MOHAMMAD HOSSEIN MOHAMMADI DAVOOD BASHASH 《Biocell》2020,44(2):183-192
Pathogenesis of chronic myeloid leukemia (CML) has mostly been studied with regard to the oncogenic role
of BCR/ABL fusion; however, recent disclosures have declared that the challenges with the treatment of CML patients
would not be resolved until the role of other aberrancies is ignored. Given the involvement of cyclin-dependent kinases
(CDKs) in the pathogenesis of CML, the present study aimed to investigate the effects of a multi-CDK inhibitor
AT7519 on BCR/ABL-harboring CML-derived K562 cells. Our results showed that AT7519 effectively reduced the
survival of K562 and induced its anti-proliferative effect through the induction of G2/M arrest due to elevated p21
and p27. The resulting data also revealed that either direct or indirect suppression of c-Myc using specific c-Myc
inhibitor 10058-F4 and selective PI3K inhibitor CAL-101 resulted in a superior cytotoxicity, suggesting that the
activation of PI3K pathway could attenuate antileukemic effects of the inhibitor, at least partly, through a c-Mycdependent mechanism. To the best of our knowledge, to date, no study has addressed the effect of autophagy on
CML cell response to AT7519, and, herein, we proposed for the first time that the suppression of autophagy
boosted AT7519 cytotoxicity against K562. Overall, we suggested that selective CDK inhibitor AT7519 exerted
antileukemic effect against CML cells and propose a novel therapeutic application for the inhibitor either as a single
agent or in combination with c-Myc and/or PI3K inhibitors. 相似文献
19.
MOHAMMAD Reza Azad ABOLGHASEM Kamkar Rouhani BEHZAD Tokhmechi MOHAMMAD Arashi EHSAN Baratnezhad 《石油勘探与开发》2019,(4)
在多孔介质流体流动模拟中,应用网格粗化方法必须在保留重要储集层参数的空间分布的前提下,首先利用大网格粗化原始地质模型(尤其是孔隙型介质),并用数值方法求解。提出了根据属性参数的空间分布、以核函数的自适应带宽为基础的网格粗化新方法,该方法既减少了网格数量,同时也保留原始精细模型的主要非均质性特征。该方法的关键点在于可以同时对两种储集层属性参数进行网格粗化。首先计算每个储集层属性参数的带宽量或最优门槛值并得到粗化结果,然后根据最大带宽和最小带宽采用两种不同的方法对两个属性参数同时粗化。现在已经能够实现利用不同方法建立储集层两个属性参数的最终粗化模型,不同方法的网格单元数和网格位置都相同。最小带宽法的粗化误差小于最大带宽法。图6表1参29 相似文献
20.
ZAHRA GHASEMPOUR MOHAMMAD ALIZADEH MAHMOUD R BARI 《International Journal of Dairy Technology》2012,65(1):118-125
A Box‐Behnken design was applied to optimise the viability of Lactobacillus acidophilus and Bifidobacterium bifidum in probiotic yoghurt containing a novel exudative Zedo gum. The effect of incubation temperature, probiotic inoculation rate, storage time and Zedo gum concentration on quality indices of the yoghurt were explored. With respect to probiotics viability, probiotic inoculation rate was the most important factor followed by the storage time. Zedo gum did not show any significant effect on probiotics viability. The optimum conditions of probiotic yoghurt production were as follows: probiotic inoculation level, 12.8 g/100 kg of milk; incubation temperature, 41.6 °C; and Zedo gum concentration, 0.13%. 相似文献