On-Line Dial-a-Ride Problems Under a Restricted Information Model

In on-line dial-a-ride problems servers are traveling in some metric space to serve requests for rides which are presented over time. Each ride is characterized by two points in the metric space, a source, the starting point of the ride, and a destination, the endpoint of the ride. Usually it is assumed that at the release of a request, complete information about the ride is known. We diverge from this by assuming that at the release of a ride, only information about the source is given. At visiting the source, the information about the destination will be made available to the servers. For many practical problems, our model is closer to reality. However, we feel that the lack of information is often a choice, rather than inherent to the problem: additional information can be obtained, but this requires investments in information systems. In this paper we give mathematical evidence that for the problem under study it pays to invest.     

Fault tolerant network design inspired by Physarum polycephalum

Physarum polycephalum, a true slime mould, is a primitive, unicellular organism that creates networks to transport nutrients while foraging. The design of these natural networks proved to be advanced, e.g. the slime mould was able to find the shortest path through a maze. The underlying principles of this design have been mathematically modelled in literature. As in real life the slime mould can design fault tolerant networks, its principles can be applied to the design of man-made networks. In this paper, an existing model and algorithm are adapted and extended with stimulation and migration mechanisms which encourage formation of alternative paths, optimize edge positioning and allow for automated design. The extended model can then be used to better design fault tolerant networks. The extended algorithm is applied to several national and international network configurations. Results show that the extensions allow the model to capture the fault tolerance requirements more accurately. The resulting extended algorithm overcomes weaknesses in geometric graph design and can be used to design fault tolerant networks such as telecommunication networks with varying fault tolerance requirements.     

Exhibiting Architecture à la Manière de

Contemporary architecture exhibitions constitute an adventurous domain involving architects, artists, curators, and scholars in various roles. Not only do architecture exhibitions mediate designs and research, they advance particular auteur approaches to the very practice of exhibiting. This article presents a hands-on study of selected exhibition authors' means and strategies in making architecture exhibitions. The basis for comparison in this research-by-design project is a brief to display student work in the context of an architecture department.     

Ethnic differences in realising desires to leave urban neighbourhoods

Selective mobility into and out of urban neighbourhoods is one of the main driving forces of segregation. Earlier research has found group differences in who wants to leave or who leaves certain types of neighbourhoods. A factor that has received little attention so far is that some residents will have a desire to leave their neighbourhood, but are unable to do so. If there are differences between population groups in the realisation of desires to leave the neighbourhood, this might lead to involuntary segregation. This paper uses a unique combination of register data and survey data. We combine data from a large housing survey in the Netherlands (WoON) with longitudinal register data from the Netherlands (SSD) which contains individual-level information on residential mobility histories. This allows us to study whether households with a desire to leave their neighbourhood do realise this desire and which households are successful in leaving which neighbourhoods. A more thorough insight in who wants to leave which neighbourhoods but is unable to do so will contribute to a better understanding of selective mobility and segregation. We find that ethnic minorities and low-income households are less likely to realise a desire to leave their neighbourhood. We expected that ethnic minorities would be especially unsuccessful in realising desires to leave minority concentration neighbourhoods; however, for none of the ethnic groups we found an effect of neighbourhood ethnic composition on the realisation of desires to leave.     

The implementation deficits of adaptation and mitigation: green buildings and water security in Amsterdam and Boston

Frameworks of environmental regulations are fundamental yet problematic factors in achieving climate mitigation and adaptation policy goals. Recent theoretical arguments claim the value of general legal frameworks to enable experimentation and contextual adaptation of policies. However, empirical research regarding the effects of both general and specific norms in the practice of urban intervention remains limited. In this article we empirically discern how city governments deal with the tension between control and flexibility in the implementation of urban climate change goals. We argue that policies of adaptation/mitigation face two types of implementation problems: non-adaptive implementation and non-implementation. The first stems from an excessively constraining use of rules, while the second derives from a too general and undefined regulatory framework. Analysing two empirical cases in Amsterdam, Netherlands and Boston, MA, USA, we conclude that there are three elements that affect the way actors deal with these deficits: the level of scale at which regulations are established, the degree of land ownership which provides margin of manoeuvre to public authorities, and the sense of political urgency behind mitigation and adaptation policies.     

Tactically ambiguous performance: the 1:1 model of Mies’s Krefeld Golf Clubhouse Project by Robbrecht en Daem architecten

A temporary and fragmentary 1:1 model of Mies van der Rohe’s unexecuted golf clubhouse project for Krefeld was designed by Robbrecht en Daem architecten and built largely in plywood near to the project's original site in the summer of 2013. This article analyses the project against the background of the debate on contemporary facsimile monument reconstructions in Germany and beyond. It argues that the design of this 1:1 model, which is not a replica nor a reconstruction, employs particular design strategies to enact the absent building in an ambiguous and self-critical way. Depending on their position in and around the pavilion, visitors alternately experienced this structure as an immersive evocation of Miesian architecture or as a self-exposing scenographic device. The theatricality of this alternation is compared to the spatio-temporal experience of tratteggio restoration techniques and to conceptual approaches to 1:1 (re)materialisations in architecture and art exhibitions. This theatrical alternation is valued as a critical complexification on the image-materiality axis of reconstructions, challenging the polarised positions in the debate about the (conditions of) legitimacy of new-old-monuments.     

Structured inspections of code

Cleanroom programming and code inspections independently provide evidence that it is more efficient to postpone the testing of code to a later stage than is usually done. This paper argues that an additional gain in quality and efficiency of development can be obtained by structuring inspections by means of an inspection protocol. The written part of such a protocol is prepared by the programmer before the inspection. It is modelled on Floyd's method for the verification of flowcharts. However, the protocol differs from Floyd's method in being applicable in practice. Structured inspections gain this advantage by not attempting to be a proof; they are no more than an articulation of existing forms of inspection. With the usual method of structured programming it may be difficult to prepare the inspection protol. On the other hand, ‘assertion-driven programming’ (of which an example is included in this paper) not only facilitates protocol preparation, but also the coding itself.     

The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease

Although the number of therapeutic options for the treatment of inflammatory bowel disease (IBD) has increased in recent years, patients suffer from decreased quality of life due to non-response or loss of response to the currently available treatments. An increased understanding of the disease’s etiology could provide novel insights for treatment strategies in IBD. Lymphatic system components are generally linked to immune responses and presumably related to inflammatory diseases pathophysiology. This review aims to summarize findings on immune-mediated mechanisms in lymphoid tissues linked with IBD pathogenesis and (potential) novel treatments. Enhanced innate and adaptive immune responses were observed in mesenteric lymph nodes (MLNs) and other lymphoid structures, such as Peyer’s patches, in patients with IBD and in animal models. Furthermore, the phenomenon of lymphatic obstruction in the form of granulomas in MLNs and lymphatic vessels correlates with disease activity. There is also evidence that abnormalities in the lymphatic stromal components and lymph node microbiome are common in IBD and could be exploited therapeutically. Finally, novel agents targeting lymphocyte trafficking have been added to the treatment armamentarium in the field of IBD. Overall, gut-associated lymphoid tissue plays a key role in IBD immunopathogenesis, which could offer novel therapeutic targets.