State-of-the-art nanoplatform-integrated MALDI-MS impacting resolutions in urinary proteomics

Urine proteomics has become a subject of interest, since it has led to a number of breakthroughs in disease diagnostics. Urine contains information not only from the kidney and the urinary tract but also from other organs, thus urinary proteome analysis allows for identification of biomarkers for both urogenital and systemic diseases. The following review gives a brief overview of the analytical techniques that have been in practice for urinary proteomics. MALDI-MS technique and its current application status in this area of clinical research have been discussed. The review comments on the challenges facing the conventional MALDI-MS technique and the upgradation of this technique with the introduction of nanotechnology. This review projects nano-based techniques such as nano-MALDI-MS, surface-assisted laser desorption/ionization, and nanostructure-initiator MS as the platforms that have the potential in trafficking MALDI-MS from the lab to the bedside.     

On a single server queue with two-stage heterogeneous service and deterministic server vacations

We analyse a single server queue with Poisson arrivals, two stages of heterogeneous service with different general (arbitrary) service time distributions and binomial schedule server vacations with deterministic (constant) vacation periods. After first-stage service the server must provide the second stage service. However, after the second stage service, he may take a vacation or may decide to stay on in the system. For convenience, we designate our model as M/G ₁, G ₂/D/1 queue. We obtain steady state probability generating function of the queue length for various states of the server. Results for some particular cases of interest such as M/E_{k 1} , E_{k 2} /D/1, M/M ₁, M ₂/D/1, M/E _k /D/1 and M/G ₁, G ₂/1 have been obtained from the main results and some known results including M/E_k /1 and M/G/1 have been derived as particular cases of our particular cases.     

Detection of nickel‐induced stress using laser‐induced fluorescence signatures from leaves of wheat seedlings

The continuous increase of heavy metal ions in the environment is imposing serious problems in agricultural yield and increases human health threats through accumulation in the food chain. Various studies have shown that heavy metals influence the metabolic processes and pigment concentrations in leaves, and thus affect the laser induced fluorescence (LIF) spectra. Leaf level in vivo LIF spectra using the 488 nm and 355 nm laser lines, fluorescence induction kinetics (FIK) using the 488 nm laser line, and photosynthetic pigments of the control and nickel treated wheat seedlings were measured. The peak parameters of the blue and UV‐excited spectral bands were calculated by Gaussian curve fitting. The FIK measured at both the chlorophyll (Chl) fluorescence bands was used to evaluate the fluorescence decrease ratio (R _Fd). The variations in R _Fd and fluorescence ratios of intensities, bandwidth and band area, with varying concentrations of nickel, were revealed as promising parameters in determining the health status of wheat seedlings. These leaf level findings can be extended at canopy level in the field using laser based light detection and ranging (LIDAR) systems.     

The role of anthropometry in designing for sustainability

An understanding of human factors and ergonomics facilitates the design of artefacts, tasks and environments that fulfil their users’ physical and cognitive requirements. Research in these fields furthers the goal of efficiently accommodating the desired percentage of user populations through enhanced awareness and modelling of human variability. Design for sustainability (DfS) allows for these concepts to be leveraged in the broader context of designing to minimise negative impacts on the environment. This paper focuses on anthropometry and proposes three ways in which its consideration is relevant to DfS: reducing raw material consumption, increasing usage lifetimes and ethical human resource considerations. This is demonstrated through the application of anthropometry synthesis, virtual fitting, and sizing and adjustability allocation methods in the design of an industrial workstation seat for use in five distinct global populations. This work highlights the importance of and opportunities for using ergonomic design principles in DfS efforts.

Practitioner Summary: This research demonstrates the relevance of some anthropometry-based ergonomics concepts to the field of design for sustainability. A global design case study leverages human variability considerations in furthering three sustainable design goals: reducing raw material consumption, increasing usage lifetimes and incorporating ethical human resource considerations in design.     

Fluorescence properties and energy transfer mechanism of Sm ion in lead telluroborate glasses

We report the fluorescence properties of Sm³⁺-doped lead telluroborate glasses of composition PbF₂.TeO₂.H₃BO₃.Sm₂O₃ as a function of Sm³⁺ concentration. A Judd-Ofelt scheme was used to determine the intensity parameters and radiative properties of Sm³⁺ ion. The emission and decay measurements were carried out at 402 nm excitation. Beyond 1.0 mol% Sm³⁺ concentration, the luminescence quenching is observed. The decay curves of ⁴G_5/2 level are well fitted to a single exponential function. The evaluated radiative properties suggest that the ⁴G_5/2 → ⁶H_7/2 transition is responsible for reddish-orange luminescence which might be used in the development of visible lasers.     

The Limiting Density of Unit Root Test Statistics: A Unifying Technique

In this note we introduce a simple principle to derive a constructive expression for the density of the limiting distribution, under the null hypothesis, of unit root statistics for an AR(1)-process in a variety of situations. We consider the case of unknown mean and reconsider the well-known situation where the mean is zero. For long-range dependent errors we indicate how the principle might apply again. We also show that in principle the method also works for a near unit root case. Weak convergence and subsequent Karhunen-Loeve expansion of the weak limit of the partial sum process of the errors plays an important role, along with the evaluation of a certain normal type integral with complex mean and variance. For independent and long range dependent errors this weak limit is ordinary and fractional Brownian motion respectively.
AMS 1991 subject classification. Primary 62M10; secondary 62E20.     

Transcritical CO2 Heat Pump Dryer: Part 2. Validation and Simulation Results

The simulation model of a transcritical CO₂ heat pump dryer presented in Part 1 has been first validated with available experimental data in this part and then used to simulate the heat pump dryer to study the variation of performance parameters such as heating COP, moisture extraction rate, and specific moisture extraction rate. The validation with experimental data shows that the model slightly over predicts the system performance. The possible reasons for the difference between experimental and numerical results are explained. Simulation results show the effect of key operating parameters such as bypass air ratio, re-circulation air ratio, dryer efficiency, ambient condition (temperature and relative humidity), and air mass flow rate. Results show that unlike bypass air ratio and ambient relative humidity, the effect of dryer efficiency, recirculation air ratio, ambient temperature, and air mass flow rate are very significant as far as the system performance is concerned.     

Electron-electron scattering and ultrasonic attenuation in potassium

The electron-electron scattering contribution to the ultrasonic attenuation in potassium at low temperatures is evaluated using the Landau Fermi liquid theory. The scattering function is evaluated using the approximation suggested by MacDonald and Geldart. The results are compared with theoretically evaluated electron-phonon scattering contributions. The results show that the electron-electron scattering contribution is of the same order as the electron-phonon scattering contribution in the 2–5 K range. Below 2 K the electron-electron scattering predominates.     

Development of pitch-based carbon–copper composites

Carbon–copper composites with varying copper to carbon ratio of 0.66–1.5 (by weight) were developed from coal-tar-pitch-derived green coke (as such or modified with natural graphite) as carbon source and electrolytic grade copper powder at different heat treatment temperatures (HTTs) of 1000–1400 °C. The physical, mechanical, and electrical properties differ depending upon the HTT and also on copper to carbon ratio (Cu/C). The composites prepared at HTT of 1100 °C having Cu/C ratio of 0.66 and 0.9 exhibited a high bending strength of 150 and 140 MPa, bulk density of 2.63 and 2.81 gm/cm³, electrical resistivity of 1.6 and 0.96 m Ω cm and shore hardness of 88 and 84, respectively, in spite of well-known inadequate wettability between copper and carbon. Increasing the temperature from 1100 °C for processing of the composites deteriorated the properties mainly due to the loss of copper through melting above 1100 °C as revealed by X-ray, scanning electron microscopy, thermal analysis and EDAX studies.     

Oxidation of polycyclic aromatic hydrocarbons with hydrogen peroxide catalyzed by Iron(III)porphyrins

A variety of iron-metallated functional porphyrins have been synthesized and their catalytic activity to oxidize polycyclic aromatic hydrocarbons, (PAHs) using hydrogen peroxide as oxidant was investigated. It was found that iron-metallated porphyrins bearing strong electronegative groups at β-pyrrolic positions show an exceptionally high catalytic efficiency.