In this study, we investigated the fatigue behavior of stent-like diamond specimens with particular attention paid to the nature of the test specimen, the constitutive model for the finite element analyses and the displacement condition. A newly designed test rig did enhance the investigation and results with respect to the simulation of the expected in vivo displacement conditions. The excellent performance of the new test method presented within our study provides a good basis for future tests without risk of compromised results due to differing characteristics between test specimens and finished stents, inappropriate displacement conditions or constitutive material model and provides a high reliability and applicability of the results to actual stents. 相似文献
The widespread development and use of implants made from NiTi is accompanied by the publication of many NiTi material characterization studies. These publications have increased significantly the knowledge about the mechanical properties of NiTi. However, this knowledge also increased the complexity of the numerical simulation of NiTi implants or devices. This study is focused on the uniaxial behavior of NiTi tubing due to cyclic loading and had the goal to deliver both precise and application-oriented results. Single aspects of this study have already been published (Wagner in Ein Beitrag zur strukturellen und funktionalen Ermüdung von Drähten und Federn aus NiTi-Formgedaechtnislegierungen, Ph.D. Thesis, 2005; Eucken and Duerig in Acta Metall 37:2245-2252, 1989; Yawny et al. in Z Metallkd 96:608-618, 2005); however, there is no publication known that shows all the single effects combined in a ??duty cycle case.?? It was of particular importance to summarize the main effects of pre-strain and subsequent small or large strain amplitudes on the material properties. The phenomena observed were captured in an extended Abaqus® Nitinol material model, presented by Rebelo et al. (A Material Model for the Cyclic Behavior of Nitinol, SMST Extended Abstracts 2010). The cyclic tensile tests were performed using a video extensometer to obtain accurate strain measurement on small electro-polished dog-bone specimen that were incorporated into a stent framework so that standard manufacturing methods could be used for the fabrication. This study indicates that a prestrain beyond 6% strain alters the transformation plateaus and if the cyclic displacement amplitude is large enough, additional permanent deformations are observed, the lower plateau and most notably the upper plateau change. The changes to the upper plateau are very interesting in the sense that an additional stress plateau develops: its ??start stress?? is lowered thereby creating a new plateau up to the highest level of cyclic strain, followed by resuming the original plateau until full transformation. This study was conducted in the course of the work of a consortium of several stent manufacturers, SAFE Technology Limited and Dassault Systèmes Simulia Corp., dedicated to the development of fatigue laws suitable for life prediction of Nitinol devices. 相似文献
Scientometrics - The long and established roots of biographical research have been well documented, over the last decades, in a rich body of reflections about the main trends, traditions and... 相似文献
In this paper, we investigate the issue of error control in wireless communication networks. We review the alternative error
control schemes available for providing reliable end-to-end communication in wireless environments. Through case studies,
the performance and tradeoffs of these schemes are shown. Based on the application environments and QoS requirements, the
design issues of error control are discussed to achieve the best solution.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
The use of chelating agents as cleaning chemicals to remove metal deposits is gaining interest. In this study the Electrochemical behavior of vanadium in EDTA, EA and EAC solutions was studied using AC impedance technique at different immersion time. The results indicate that the values of Rct for EA solution are higher than that for EDTA and EAC. This may be due to the presence of ascorbic acid as reducing agent. The presence of surface film is confirmed by capacitance measurements. It is shown that the capacitance is time‐dependent. Generally, the capacitance decreases with immersion time and this can be discussed on the basis that the concentration of vanadium ions at the interface increases with immersion time. 相似文献
The utility of single-chain Fv proteins as therapeutic agentswould be realized if the circulating lives of these minimalantigen-binding polypeptides could be both prolonged and adjustable.We have developed a general strategy for creating tailored monoPEGylatedsingle-chain antibodies. Free cysteine residues were engineeredin an anti-TNF- 相似文献
Investigation of novel biomaterials for bone engineering is based on the development of porous scaffolds, which should match
the properties of the tissue that is to be replaced. These materials need to be biocompatible, ideally osteoinductive, osteoconductive,
and mechanically well-matched. In the present paper, we report the preparation and characterization of hybrid macroporous
scaffold of polyvinyl alcohol (PVA)/bioactive glass through the sol–gel route. Hybrids containing PVA (80, 70 and 60 wt%)
and bioactive glass with composition 58SiO2–33CaO–9P2O5 were synthesized by foaming a mixture of polymer solution and bioactive glass via sol–gel precursor solution. PVA with two
different degree of hydrolysis (DH), 98.5% (high degree) and 80% (low degree) were also investigated, in order to evaluate
the influence of residual acetate group present in polymer chain on the final structure and properties of 3D porous composite
produced. The microstructure, morphology and crystallinity of the hybrid porous scaffolds were characterized by X-ray diffraction
(XRD), Infrared Fourier Transform spectrometry (FTIR) and Scanning electron microscopy (SEM/EDX) analysis. In addition, specific
surface area was assessed by B.E.T. nitrogen adsorption method and mechanical behavior was evaluated by compression tests.
Preliminary cytotoxicity and cell viability were also performed by the MTT assay. VERO cell monolayers were grown in 96-well
microtiter plates. The results have clearly showed that hybrid foams of polyvinyl alcohol/bioactive glass (PVA/BG) with interconnected
macroporous 3D structure were successfully produced. All the tested hybrids of PVA/BG have showed adequate cell viability
properties for potential biological applications. 相似文献
The fascinating, complex behavior of ionic liquids is analyzed using a molecular perspective that emphasizes the doubly dual nature of ionic liquids underlying the existence of cations and anions forming high- and low-charge-density regions. Our work bridges the liquid, gas, and solid phases spanning 5 years of research on themes as diverse as the vaporization, liquid-liquid demixing, solidification, and thermophysical behavior of ionic liquids and their mixtures and solutions. 相似文献
A rhodium‐catalyzed asymmetric synthesis of 5,5‐disubstituted cyclohexa‐1,3‐dienes has been achieved by [2+2+2] cycloaddition reactions between diynes and Morita–Baylis–Hillman (M‐B‐H) adducts as unsaturated substrates. Products containing two adjacent chiral centres (quaternary and tertiary, respectively) were obtained with complete diastereoselectivity and high enantioselectivity (84–97%) through a kinetic resolution of the M‐B‐H adduct. Furthermore, these highly substituted cyclohexadienes reacted with dienophiles to afford the corresponding Diels–Alder cycloadducts in good yields.
The concern about accidents involving radioactive materials has led to the search of alternative methods to quickly identify and quantify radionuclides in workers and in the population. One of the options to face up an eventual demand for mass monitoring of internal contamination is the use of a nuclear medicine diagnostic equipment known as gamma camera, a device used to scan patients who have been administered specific amounts of radioactive materials for medical purposes. Although the gamma camera is used for image diagnosis, it can be calibrated with anthropomorphic phantoms or point sources for the quantification of radionuclide activities in the human body. This work presents a protocol for the calibration of gamma cameras for such application. In order to evaluate the suitability of this type of equipment, a gamma camera available in a public hospital located in Rio de Janeiro was calibrated for the in vivo measurement of 131I. The calibration includes the determination of detection efficiencies and minimum detectable activities for each radionuclide. The results show that the gamma camera presents enough sensitivity to detect activity levels corresponding to effective doses below 1 mSv. The protocol is the basis to establish a network of Nuclear Medicine Centres, located in public hospitals in eight countries of Latin America (Argentina, Brazil, Colombia, Cuba, Chile, Mexico, Peru and Uruguay) and in Spain that could be requested to collaborate in remediation actions in the event of an accident involving incorporation of radioactive materials. This protocol is one of the most significant outputs of the IAEA-ARCAL Project (RLA/9/049-LXXVIII) aimed to the Harmonization of Internal Dosimetry Procedures. 相似文献