Application of virtual reality for peritoneal dialysis exchange learning in patients with end-stage renal disease and cognitive impairment

Virtual Reality - Cognitive impairment is not uncommon in patients with end-stage renal disease and can make it more difficult for these patients to carry out peritoneal dialysis (PD) on their own....     

Ferritin Protein Regulates the Degradation of Iron Oxide Nanoparticles

Proteins implicated in iron homeostasis are assumed to be also involved in the cellular processing of iron oxide nanoparticles. In this work, the role of an endogenous iron storage protein—namely the ferritin—is examined in the remediation and biodegradation of magnetic iron oxide nanoparticles. Previous in vivo studies suggest the intracellular transfer of the iron ions released during the degradation of nanoparticles to endogenous protein cages within lysosomal compartments. Here, the capacity of ferritin cages to accommodate and store the degradation products of nanoparticles is investigated in vitro in the physiological acidic environment of the lysosomes. Moreover, it is questioned whether ferritin proteins can play an active role in the degradation of the nanoparticles. The magnetic, colloidal, and structural follow‐up of iron oxide nanoparticles and proteins in lysosome‐like medium confirms the efficient remediation of potentially harmful iron ions generated by nanoparticles within ferritins. The presence of ferritins, however, delays the degradation of particles due to a complex colloidal behavior of the mixture in acidic medium. This study exemplifies the important implications of intracellular proteins in processes of degradation and metabolization of iron oxide nanoparticles.     

Analytical‐Based Methodologies for Examining the In Vitro Absorption,Distribution, Metabolism,and Elimination (ADME) of Silver Nanoparticles

The clinical applications of silver nanoparticles (AgNPs) remain limited due to the lack of well‐established methodologies for studying their nanokinetics. Hereby, the primary goal is to adapt a suite of analytical‐based methodologies for examining the in vitro absorption, distribution, metabolism, and elimination of AgNPs. Vero 76 and HEK 293 cells are exposed to ≈10‐nm spherical AgNPs⁺ and AgNPs^? at relevant concentrations (0–300 µg mL^?1) and times (4–48 h). Absorption: Inductively coupled plasma optical emission spectroscopy (ICP‐OES) demonstrates that the two AgNP formulations are not bioequivalent. For example, different bioavailabilities (C _maximum < 20.7 ± 4% and 6.82 ± 0.4%), absorption times (T _maximum > 48 and ≈24 h), and absorption rate laws (first‐ and zeroth‐order at 300 µg mL^?1) are determined in Vero 76 for AgNPs⁺ and AgNPs^?, respectively. Distribution: Raman and CytoViva hyperspectral imaging show different cellular localizations for AgNPs⁺ and AgNPs^?. Metabolism: Cloud point extraction (CPE)‐tangential flow filtration (TFF) reveal that ≤ 11% ± 4% of the administered, sublethal AgNPs release Ag⁺ and contribute to the observed cytotoxicity. Elimination: ICP‐OES‐CPE suggests that AgNPs are cleared via exocytosis.     

Spontaneously Embedded Scattering Structures in a Flexible Substrate for Light Extraction

A flexible hazy substrate (FHS) with embedded air bubbles to increase light extraction efficiency of organic light‐emitting diodes (OLEDs) is reported. In order to embed the air bubbles in the flexible substrate, micropatterned substrates are fabricated by plasma treatment, and then coated with a planarization layer. During the planarization layer coating, air bubbles are trapped between the substrate and the planarization layer. The haze of the FHS can be controlled from 1.7% to 68.4% by changing the size of micropatterns by adjusting the plasma treatment time. The FHS shows average haze of 68.4%, average total transmittance of 90.3%, and extremely flat surface with average roughness (R _a) of 1.2 nm. Rigorous coupled‐wave analysis and finite‐difference time‐domain simulations are conducted to demonstrate that the air bubbles in the substrate can effectively extract photons that are trapped in the substrate. The FHS increases the power efficiency of OLEDs by 22% and further increases by 91% combined with an external extraction layer. Moreover, the FHS has excellent mechanical flexibility. No defect has been observed after 10 000 bending cycles at bending radius of 4 mm.     

Development of categorical representations for above and below spatial relations in 3- to 7-month-old infants.

A series of experiments examined the abilities of infants to form categorical representations for the spatial relations above and below. Exp 1 provided evidence that 3–4 mo olds can form categorical representations for above and below when a diamond shape was presented above or below a horizontal bar. Exps 2 and 3 showed that 3- and 4-mo olds did not form categorical representations for above and below when a number of discriminably different shapes (e.g., a diamond, a triangle, a dot) appeared above or below the bar. These more abstract categorical representations for above and below were formed by 6- to 7-mo olds (Exp 4). The findings suggest an experientially or maturationally based trend, from concrete to abstract, in the categorical representation of common spatial relations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The use of coevolution and the artificial immune system for ensemble learning

This paper presents two new approaches for constructing an ensemble of neural networks (NN) using coevolution and the artificial immune system (AIS). These approaches are extensions of the CLONal Selection Algorithm for building ENSembles (CLONENS) algorithm. An explicit diversity promotion technique was added to CLONENS and a novel coevolutionary approach to build neural ensembles is introduced, whereby two populations representing the gates and the individual NN are coevolved. The former population is responsible for defining the ensemble size and selecting the members of the ensemble. This population is evolved using the differential evolution algorithm. The latter population supplies the best individuals for building the ensemble, which is evolved by AIS. Results show that it is possible to automatically define the ensemble size being also possible to find smaller ensembles with good generalization performance on the tested benchmark regression problems. More interestingly, the use of the diversity measure during the evolutionary process did not necessarily improve generalization. In this case, diverse ensembles may be found using only implicit diversity promotion techniques.     

Simulation based alternatives for overall process improvement at the cardiac catheterization lab

Cardiac catheterization is one of the critical procedures in patient care. It is pertinent for all process related issues in this department to be handled with due priority. This research is a cross-functional effort with a leading hospital that was in its planning stage to implement an overall process improvement at its cardiac catheterization lab department. It has been determined that significant process delays exist in this department. One of the identified key factors to process improvement was to reduce patient turnaround time. Process mapping was used to study the system and identify potential sources of delays in the system. A set of qualitative recommendations were put forward. These recommendations, include the reduction of wait time of outpatients and inpatients and the reduction of non-value-added times such as transfer time of patients, were evaluated using a discrete event simulation approach. The simulation study shows that the daily operating hours at the catheterization lab could be reduced, aiding to reallocate staff for discharging other duties, as the hospital may require.     

Understanding the ways in which design features of educational websites impact upon student learning outcomes in blended learning environments

This study investigated the effectiveness, in terms of the attainment of relevant learning outcomes, of the types of learning promoted by educational features commonly incorporated in course management systems. Twenty-one courses with significant use of the Internet, but with face-to-face teaching as the predominant instructional mode, were investigated. Five hundred and ninety-five students taking these 21 courses completed a questionnaire which gave feedback on the extent of use of and quality of implementation of internet features, as well as their perception of the attainment of outcomes relating to approaches to learning, communication skills and understanding of content. A confirmatory factor analysis of scales pertinent to information presentation and constructive dialogue features showed a very poor fit to the data, indicating that the two types of function did not act in concert. Structural equation modelling was used to test instructional models in presage–process–product format for ‘information’ and ‘dialogue’ features. The information one showed a marginal fit to the data, but the dialogue one a very good fit. This shows that using the Internet for presenting information in a blended environment does not seem to effectively help students achieve learning outcomes. Using features which promote constructive dialogue and interactive learning activities encourages a deep approach to learning, the development of communication skills and enhanced understanding of content.     

Robust admissibility and admissibilisation of uncertain discrete singular time-delay systems

This paper is concerned with the characterisation of robust admissibility and admissibilisation for uncertain discrete-time singular system with interval time-varying delay. Considering the norm-bounded uncertainty and the interval time-varying delay, a new comparison model is introduced to transform the original singular system into two connected subsystems. After this transformation, a singular system without uncertainty and delay can be handled by the Lyapunov–Krasovskii functional method. By virtue of the scaled small gain theorem, an admissibility condition of the original singular system is proposed in terms of linear matrix inequalities. Moreover, the problem of robust admissibilisation of uncertain discrete singular time-varying system is also studied by iterative linear matrix inequality algorithm with initial condition optimisation. Several numerical examples are used to illustrate that the results are less conservative than existing ones.