全文获取类型
收费全文 | 2391篇 |
免费 | 70篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 24篇 |
综合类 | 5篇 |
化学工业 | 958篇 |
金属工艺 | 39篇 |
机械仪表 | 41篇 |
建筑科学 | 196篇 |
矿业工程 | 6篇 |
能源动力 | 65篇 |
轻工业 | 190篇 |
水利工程 | 13篇 |
石油天然气 | 2篇 |
武器工业 | 4篇 |
无线电 | 127篇 |
一般工业技术 | 310篇 |
冶金工业 | 129篇 |
原子能技术 | 32篇 |
自动化技术 | 322篇 |
出版年
2022年 | 22篇 |
2021年 | 52篇 |
2020年 | 29篇 |
2019年 | 27篇 |
2018年 | 35篇 |
2017年 | 26篇 |
2016年 | 63篇 |
2015年 | 58篇 |
2014年 | 54篇 |
2013年 | 105篇 |
2012年 | 90篇 |
2011年 | 120篇 |
2010年 | 99篇 |
2009年 | 102篇 |
2008年 | 97篇 |
2007年 | 84篇 |
2006年 | 91篇 |
2005年 | 80篇 |
2004年 | 64篇 |
2003年 | 45篇 |
2002年 | 53篇 |
2001年 | 50篇 |
2000年 | 54篇 |
1999年 | 64篇 |
1998年 | 55篇 |
1997年 | 56篇 |
1996年 | 54篇 |
1995年 | 54篇 |
1994年 | 45篇 |
1993年 | 28篇 |
1992年 | 41篇 |
1991年 | 41篇 |
1990年 | 31篇 |
1989年 | 40篇 |
1988年 | 29篇 |
1987年 | 32篇 |
1986年 | 29篇 |
1985年 | 24篇 |
1984年 | 30篇 |
1983年 | 27篇 |
1982年 | 17篇 |
1981年 | 29篇 |
1980年 | 23篇 |
1979年 | 19篇 |
1978年 | 20篇 |
1977年 | 22篇 |
1976年 | 18篇 |
1975年 | 18篇 |
1974年 | 21篇 |
1973年 | 19篇 |
排序方式: 共有2463条查询结果,搜索用时 15 毫秒
91.
92.
93.
This article debates the production of mouldings made of keratin. It is demonstrated that the properties of keratin allow
for being processed with heat and pressure to manufacture tough mouldings without chemical preprocessing of the used wool.
This material thus has a high potential as a bioplastic, because it potentially can be used with conventional plastic manufacturing
techniques. Additionally, it might also serve as an adhesive in various applications. The biobased material might become a
sustainable source for mouldings.
相似文献
Manfred DrackEmail: |
94.
The Alternaria toxins alternariol (AOH; 3,7,9-trihydroxy-1-methyl-6H-benzo[c]chromen-6-one) and alternariol methyl ether (AME, 3,7-dihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one) are common contaminants of food and feed, but their oxidative metabolism in mammals is as yet unknown. We have therefore incubated AME and AOH with microsomes from rat, human, and porcine liver and analyzed the microsomal metabolites with HPLC and GC-MS/MS. Seven oxidative metabolites of AME and five of AOH were detected. Their chemical structures were derived from their mass spectra using deuterated trimethylsilyl (TMS) derivatives, and from the information obtained from enzymatic methylation. Several of the metabolites were identified by comparison with synthetic reference compounds. AME as well as AOH were monohydroxylated at each of the four possible aromatic carbon atoms and also at the methyl group. In addition, AME was demethylated to AOH and dihydroxylated to a small extent. As the four metabolites arising through aromatic hydroxylation of AME and AOH are either catechols or hydroquinones, the oxidative metabolism of these mycotoxins may be of toxicological significance. 相似文献
95.
Lebedkin S Blum C Stürzl N Hennrich F Kappes MM 《The Review of scientific instruments》2011,82(1):013705
We describe the simple modification of a confocal Raman imaging microscope to incorporate two ultra-narrow holographic notch filters. The modified microscope rejects the laser excitation line (Rayleigh peak) by a discrimination factor of ~10(11) and allows simultaneous measurements of Stokes/anti-Stokes Raman shifts as close as ~10/20 cm(-1) to the Rayleigh line. The extremely high rejection ratio of the Rayleigh peak results in its intensity becoming comparable to typical Raman scattering signals. This is essential for micro-Raman spectroscopy and imaging in the low-wavenumber region. We illustrate the resulting performance with measurements on silicon/silica, sapphire, sulfur, L-cystine, as well as on single-walled carbon nanotubes (SWNTs). We find that both aggregated (bulk) and individual (deposited on substrate) SWNTs demonstrate strong and broad characteristic Raman features below ~100 cm(-1)-in a region which has remained essentially unexplored in measurements of bulk SWNT samples and which has so far been inaccessible for Raman spectroscopy of individual SWNTs. 相似文献
96.
Dr. Li Di Prof. Per Artursson Dr. Alex Avdeef Prof. Leslie Z. Benet Prof. J. Brian Houston Dr. Manfred Kansy Edward H. Kerns Prof. Hans Lennernäs Dr. Dennis A. Smith Prof. Kiyohiko Sugano 《ChemMedChem》2020,15(20):1862-1874
Passive permeability is a key property in drug disposition and delivery. It is critical for gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance mechanisms and drug-drug interactions. Passive diffusion rate is translatable across tissues and animal species, while the extent of absorption is dependent on drug properties, as well as in vivo physiology/pathophysiology. Design principles have been developed to guide medicinal chemistry to enhance absorption, which combine the balance of aqueous solubility, permeability and the sometimes unfavorable compound characteristic demanded by the target. Permeability assays have been implemented that enable rapid development of structure-permeability relationships for absorption improvement. Future advances in assay development to reduce nonspecific binding and improve mass balance will enable more accurately measurement of passive permeability. Design principles that integrate potency, selectivity, passive permeability and other ADMET properties facilitate rapid advancement of successful drug candidates to patients. 相似文献
97.
Thomas Kubin Praveen Gajawada Peter Bramlage Stefan Hein Benedikt Berge Ayse Cetinkaya Heiko Burger Markus Schnburg Wolfgang Schaper Yeong-Hoon Choi Manfred Richter 《International journal of molecular sciences》2022,23(3)
Oncostatin M (OSM), a member of the interleukin-6 family, functions as a major mediator of cardiomyocyte remodeling under pathological conditions. Its involvement in a variety of human cardiac diseases such as aortic stenosis, myocardial infarction, myocarditis, cardiac sarcoidosis, and various cardiomyopathies make the OSM receptor (OSMR) signaling cascades a promising therapeutic target. However, the development of pharmacological treatment strategies is highly challenging for many reasons. In mouse models of heart disease, OSM elicits opposing effects via activation of the type II receptor complex (OSMR/gp130). Short-term activation of OSMR/gp130 protects the heart after acute injury, whereas chronic activation promotes the development of heart failure. Furthermore, OSM has the ability to integrate signals from unrelated receptors that enhance fetal remodeling (dedifferentiation) of adult cardiomyocytes. Because OSM strongly stimulates the production and secretion of extracellular proteins, it is likely to exert systemic effects, which in turn, could influence cardiac remodeling. Compared with the mouse, the complexity of OSM signaling is even greater in humans because this cytokine also activates the type I leukemia inhibitory factor receptor complex (LIFR/gp130). In this article, we provide an overview of OSM-induced cardiomyocyte remodeling and discuss the consequences of OSMR/gp130 and LIFR/gp130 activation under acute and chronic conditions. 相似文献
98.
Morgenthaler M Schweizer E Hoffmann-Röder A Benini F Martin RE Jaeschke G Wagner B Fischer H Bendels S Zimmerli D Schneider J Diederich F Kansy M Müller K 《ChemMedChem》2007,2(8):1100-1115
This review describes simple and useful concepts for predicting and tuning the pK(a) values of basic amine centers, a crucial step in the optimization of physical and ADME properties of many lead structures in drug-discovery research. The article starts with a case study of tricyclic thrombin inhibitors featuring a tertiary amine center with pK(a) values that can be tuned over a wide range, from the usual value of around 10 to below 2 by (remote) neighboring functionalities commonly encountered in medicinal chemistry. Next, the changes in pK(a) of acyclic and cyclic amines upon substitution by fluorine, oxygen, nitrogen, and sulfur functionalities, as well as carbonyl and carboxyl derivatives are systematically analyzed, leading to the derivation of simple rules for pK(a) prediction. Electronic and stereoelectronic effects in cyclic amines are discussed, and the emerging computational methods for pK(a) predictions are briefly surveyed. The rules for tuning amine basicities should not only be of interest in drug-discovery research, but also to the development of new crop-protection agents, new amine ligands for organometallic complexes, and in particular, to the growing field of amine-based organocatalysis. 相似文献
99.
Claudia Waldinger Manfred Schneider 《Journal of the American Oil Chemists' Society》1996,73(11):1513-1519
Lipases that display high regioselectivities and broad substrate tolerance were used as catalysts for the efficient esterification
of glycerol under the conditions of irreversible acyl transfer. A variety of unsaturated fatty acids, such as oleic, linoleic,
erucic, ricinolic, hydroxystearic and coriolic acid, were used for this purpose in the form of their vinyl esters. Suitable
biocatalysts were chosen on the basis of systematic screening experiments regarding their regioselectivities (RE) and substrate
tolerances. Distinct differences were found and expressed in numerical RE values as a measure for differences of these biocatalysts
as being specific, selective, and nonspecific. Based on these experiments, a variety of molecules were synthesized on a preparative
scale (>150 mmol) in good yield (ca.85%) and with high regioisomerical purities (>95% RE). 相似文献
100.
Daniel Kleine Manfred Mürtz Jörg Lauterbach Hannes Dahnke Wolfgang Urban Peter Hering Karl Kleinermanns 《Israel journal of chemistry》2001,41(2):111-116
Cavity ring-down spectroscopy (CRDS) is a highly sensitive laser absorption method. It can be used for quantitative analysis of molecular species at the sub-ppb level. The absorption cell (cavity) is sealed by two high-reflective mirrors on each side, which results in an effective absorption path-length of some kilometers. Our experiments for atmospheric gas analysis have been carried out so far with an Excimer pumped dye laser in the UV-VIS and a CO overtone sideband laser in the wavelength region around 3 μm. Experiments with an all solid-state difference frequency laser system will follow. In the UV-VIS region, we measured trace gas molecules like SO2, NO2, and CH2O. In the mid-infrared, around 3 μm, we measured hydrocarbons like CH4, C2H6, and C2H4 with a detection limit of less than 1 ppb. The noise equivalent absorption coefficients in the MIR are in the order of 1.7·10−9 cm−1. Due to the high data acquisition rate and the high sensitivity, CRDS enables real-time detection of trace gases in ambient air. 相似文献