Long-Term Treatment with Citicoline Prevents Cognitive Decline and Predicts a Better Quality of Life after a First Ischemic Stroke

Stroke, as the leading cause of physical disability and cognitive impairment, has a very significant impact on patients’ quality of life (QoL). The objective of this study is to know the effect of citicoline treatment in Qol and cognitive performance in the long-term in patients with a first ischemic stroke. This is an open-label, randomized, parallel study of citicoline vs. usual treatment. All subjects were selected 6 weeks after suffering a first ischemic stroke and randomized into parallel arms. Neuropsychological evaluation was performed at 1 month, 6 months, 1 year and 2 years after stroke, and QoL was measured using the EuroQoL-5D questionnaire at 2 years. 163 patients were followed during 2 years. The mean age was 67.5 years-old, and 50.9% were women. Age and absence of citicoline treatment were independent predictors of both utility and poor quality of life. Patients with cognitive impairment had a poorer QoL at 2 years (0.55 vs. 0.66 in utility, p = 0.015). Citicoline treatment improved significantly cognitive status during follow-up (p = 0.005). In conclusion, treatment with long-term citicoline is associated with a better QoL and improves cognitive status 2 years after a first ischemic stroke.     

YCrO3/Al2O3 Core‐Shell Design: The Effect of the Nanometric Al2O3‐Shell on Dielectric Properties

We report a novel strategy to improve the dielectric properties of the biferroic YCrO₃ ceramic compound through interface conduction control by means of an insulating Al₂O₃ using a core‐shell design. The YCrO₃ particles were covered with several layers of insulating Al₂O₃ using the atomic layer deposition technique to produce the core‐shell structure. TEM images reveal homogeneous and well‐defined Al₂O₃ coatings of ~8, ~60, and ~130 nm thickness. XRD shows the Al₂O₃‐shell to be amorphous. The dielectric characteristics of the sintered nano‐composite were investigated in the 100 Hz–1 MHz frequency range and temperature between 300 and 580 K. As the Al₂O₃‐shell thickness covering the YCrO₃ particles is increased, a decrease of the dielectric permittivity, loss tangent and AC conductivity values was found in the whole range of temperatures and frequencies. Furthermore, the rounded hysteresis loop, typical of conductive ceramic is restored as the insulating Al₂O₃ layer becomes thicker. This behavior is explained because the insulating Al₂O₃‐shell acts as internal barrier layer localizing the surface charges on the sintered grain boundaries. This fact was confirmed by Electron Beam Induced Current technique where a clear contrast at the grain boundaries confirms the charge localization at the YCrO₃/Al₂O₃ interface. These results also reveal that the Al₂O₃‐shell induces another conductive mechanism when the insulating Al₂O₃ layer becomes thicker. Nonetheless, this new strategy is an effective approach to suppress the parasitic conductivity in polycrystalline multiferroic ceramics and increasing thus the multifuncionality.     

Modification of optical and electrical properties of zinc oxide-coated porous silicon nanostructures induced by swift heavy ion

Morphological and optical characteristics of radio frequency-sputtered zinc aluminum oxide over porous silicon (PS) substrates were studied before and after irradiating composite films with 130 MeV of nickel ions at different fluences varying from 1 × 10¹² to 3 × 10¹³ ions/cm². The effect of irradiation on the composite structure was investigated by scanning electron microscopy, X-ray diffraction (XRD), photoluminescence (PL), and cathodoluminescence spectroscopy. Current–voltage characteristics of ZnO-PS heterojunctions were also measured. As compared to the granular crystallites of zinc oxide layer, Al-doped zinc oxide (ZnO) layer showed a flaky structure. The PL spectrum of the pristine composite structure consists of the emission from the ZnO layer as well as the near-infrared emission from the PS substrate. Due to an increase in the number of deep-level defects, possibly oxygen vacancies after swift ion irradiation, PS-Al-doped ZnO nanocomposites formed with high-porosity PS are shown to demonstrate a broadening in the PL emission band, leading to the white light emission. The broadening effect is found to increase with an increase in the ion fluence and porosity. XRD study revealed the relative resistance of the film against the irradiation, i.e., the irradiation of the structure failed to completely amorphize the structure, suggesting its possible application in optoelectronics and sensing applications under harsh radiation conditions.     

Life study of a PBI-PEM fuel cell by current distribution measurement

PBI-based polymer electrolyte membrane (PEM) fuel cells have short durability comparing with Nafion ones. It is known that the presence of phosphoric acid accelerates catalyst sintering, and the polymer is susceptible to getting degraded via oxidative degradation. However, the influence of the current distribution on the degradation process has not been investigated. In this work, current distribution was measured continuously during a steady state life test that was performed in a 50-cm² PBI-PEM fuel cell. The membrane-electrode assembly was prepared using techniques that are supposed to ensure satisfactory reproducibility at global level. Two different stages, i.e., activation and degradation, were identified. They show disparities in both global and local performance. It was found that the current distribution map is very heterogeneous, with variations around ±50 % with respect to the average value during the whole lifetime of the cell. The non-uniformity of the current profile increases during the degradation, but it cannot be concluded that the current density distribution contributes to the short lifetime.     

A study on wear evaluation of railway wheels based on multibody dynamics and wear computation

The wear evolution of railway wheels is a very important issue in railway engineering. In the past, the reprofiling intervals of railway vehicle steel wheels have been scheduled according to designers’ experience. Today, more reliable and accurate tools in predicting wheel wear evolution and wheelset lifetime can be used in order to achieve economical and safety benefits. In this work, a computational tool that is able to predict the evolution of the wheel profiles for a given railway system, as a function of the distance run, is presented. The strategy adopted consists of using a commercial multibody software to study the railway dynamic problem and a purpose-built code for managing its pre- and post-processing data in order to compute the wear. The tool is applied here to realistic operation scenarios in order to assess the effect of some service conditions on the wheel wear progression.     

Digital inverse model control using Generalised holds with extensions to the adaptive case

In this paper, a digital implementation of an inverse-model based control scheme is proposed using Generalised Sampling and Hold Functions. The implementation of the controller using this kind of holds allows overcoming the difficulties related to the presence of unstable zeros in the continuous-time model and the usual appearance of unstable discretisation zeros in the discrete model when a ZOH is applied. The Generalised Sampling and Hold Functions allows obtaining a discrete model of the plant with all its zeros stable which allows realizing an exact inverse model of the plant in comparison to the use of a classical ZOH which only allows, in general, an approximate inversion of the plant. The proposed approach is then extended to the adaptive case where the stability and tracking properties of the general scheme are fully proved. Simulation examples showing the scope and application of the method are also presented.     

The input amplitude saturation problem in QFT: A survey

In this work the input amplitude saturation problem is analysed in the Quantitative Feedback Theory (QFT) framework. This paper reviews previous works in the literature dealing with the input amplitude saturation problem in the presence of an uncertain plant in the frequency domain using QFT. The objective of this paper is to compare the different available approaches and summarize the design process for each case so that this paper can be used as a tutorial; there are six main approaches to this problem. Two of these approaches use the classical two degrees of freedom control scheme for QFT; in both of these, the design constraints of a linear QFT compensator are added in the loop shaping stage: they are added in the first approach to avoid excitation of the actuator saturation and in the second one to guarantee global stability. The other three techniques are considered as anti-windup (AW) approaches. Starting from a base design in QFT with two degrees of freedom, the first AW approach introduces a third degree of freedom that guarantees the stability of the system, allowing for base designs for high performance. The other two AW approaches also introduce a third degree of freedom, but they take simple stability considerations into account and focus on the performance of the system. The last solution consists of using a reference governor technique, which guarantees the computation of a reference signal for an inner control loop that is shaped using QFT in such a way that robust stability will be guaranteed. The reference governor technique is a time domain approach that implies the resolution of an optimization problem. The rest of the approaches are frequency domain techniques based on a loop shaping method in the traditional QFT sense.     

Uncertainty in cloud service relationships: Uncovering the differential effect of three social influence processes on potential and current users

Consumer cloud services are characterized by uncertainty before usage but also for individuals who are already using the service. Our cloud service relationship model posits that individuals facing continuous uncertainty during adoption and continuance decisions rely on their social environment to make evaluations and decisions. Drawing on a representative dataset of 2011 Internet users, we distinguish three social influence processes from social influence theory (identification, internalization, and compliance) and uncover their differential effect on potential and current users’ uncertainty evaluations and on usage intentions. Our results can help cloud providers to successfully manage their relationships with potential and current users.     

Virtual Blocks: a serious game for spatial ability improvement on mobile devices

This paper presents a novel spatial instruction system for improving spatial abilities of engineering students. A 3D mobile game application called Virtual Blocks has been designed to provide a 3D virtual environment to build models with cubes that help students to perform visualization tasks to promote the development of their spatial ability during a short remedial course. A validation study with 26 freshman engineering students at La Laguna University (Spain) has concluded that the training had a measurable and positive impact on students’ spatial ability. In addition, the results obtained using a satisfaction questionnaire show that Virtual Blocks is considered an easy to use and stimulating application.     

Locality-Aware Automatic Parallelization for GPGPU with OpenHMPP Directives

The use of GPUs for general purpose computation has increased dramatically in the past years due to the rising demands of computing power and their tremendous computing capacity at low cost. Hence, new programming models have been developed to integrate these accelerators with high-level programming languages, giving place to heterogeneous computing systems. Unfortunately, this heterogeneity is also exposed to the programmer complicating its exploitation. This paper presents a new technique to automatically rewrite sequential programs into a parallel counterpart targeting GPU-based heterogeneous systems. The original source code is analyzed through domain-independent computational kernels, which hide the complexity of the implementation details by presenting a non-statement-based, high-level, hierarchical representation of the application. Next, a locality-aware technique based on standard compiler transformations is applied to the original code through OpenHMPP directives. Two representative case studies from scientific applications have been selected: the three-dimensional discrete convolution and the simple-precision general matrix multiplication. The effectiveness of our technique is corroborated by a performance evaluation on NVIDIA GPUs.