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51.
J García Marco A Miguel Sosa J García Conde A Miguel García C Arbona V Escrig I Benet I Navarro A Ruiz F Carbonell 《Canadian Metallurgical Quarterly》1994,39(4):241-244
PURPOSE: To assess the "in vivo" effect of 13-cis-retinoic acid and low dose Ara-C in MDS as well as to establish "in vitro" advantage of retinoid dose-related growth pattern on bone marrow cultures as defined by culture timing and CFU-GM proliferative response. PATIENTS AND METHODS: We evaluated 28 patients diagnosed of MDS according to FAB classification, of whom 4 cases had RA, 8 cases SRA, 14 cases RAEB and 2 cases RAEB-T. Patients who had RA and SRA were treated with oral 13-cis-retinoic acid at doses of 20-40 mg daily for 4 months and those cases with RAEB and RAEB-T had subcutaneous Ara-C at doses of 3 mg/m2 twice a day for 21 days. The "in vivo" and "in vitro" effect of retinoic acid on the haemopoietic differentiation was evaluated by the growth CFU-GM in semisolid cell culture methods. RESULTS: Increasing in vitro concentrations of 13-cis retinoic acid did not enhance the growth of myelodysplastic progenitors. Nevertheless, our study did not find any beneficial therapeutic effect of retinoic compounds in MDS patients. In this study, low-dose Ara-C (3 mg/m2) showed similar effects when compared with higher doses reported by others. Furthermore, in terms of CFU-GM proliferation the concentration of colonies before and after treatment were fairly similar in all but two patients. CONCLUSIONS: The results drawn from our study demonstrated that there is no beneficial advantage of 13-cis-retinoic acid as a differentiation inducing agent on myelodysplastic patients. In contrast, lower doses of Ara-C showed similar effects on haemopoiesis of MDS patients than standard doses of 10-20 mg/m2 but with less side effects. 相似文献
52.
Marco Franchini 《Water Resources Management》1994,8(3):225-238
With reference to the kinematic wave theory coupled with the hypothesis of constant linear velocity for the rating curve, rising limb analytical solutions have been calculated for overland flow, over an Hortonian-infiltrating surface, and sediment discharge. These analytical solutions are certainly easier to use than the numerical integration of the basic equations and they may be used to obtain an initial evaluation of the parameters of more complex models generally devised for complicated cases.Notation
a
exponent of the Horton law [T–1]
-
b
exponent of the rill erosion equation
-
B
inter-rill erosion coefficient [ML–m–2T
m–1]
-
c
sediment concentration [ML–3]
-
c
o
reference sediment concentration [ML–3]
-
E
I
inter-rill erosion [ML–2T–1]
-
E
R
rill erosion [ML–2T–1]
-
f
c
final infiltration rate of the soil [LT–1]
-
f
o
initial infiltration rate of the soil [LT–1]
-
h
flow depth [L]
-
h
o
reference flow depth [L]
-
i
infiltration rate [LT–1]
-
k
rill erosion coefficient [ML–1–b
T–1]
-
K
integration constant
-
L()
Laplace transformation
-
m
exponent of the inter-rill erosion equation
-
n
Manning's coefficient [L–1/3T]
-
p
rainfall intensity [LT–1]
-
q
water discharge per unit width [L2T–1]
-
q
s
sediment discharge per unit width [ML–1T–1]
-
t
time [T]
-
t
p
ponding time [T]
-
x
distance along the flow direction [L]
Greek Letters
coefficient of the stage-discharge equation [L2–T–1]
-
exponent of the stage-discharge equation
-
rill erosion coefficient [L–1] 相似文献
53.
Virtual Reality - The intersection between sound and music computing and Virtual Reality (VR) has grown significantly over the past decades, amounting to an established area of research today.... 相似文献
54.
Felix M. Escalante Andres L. Jutinico Marco H. Terra Adriano A. G. Siqueira 《Asian journal of control》2023,25(4):2564-2576
The natural instability of an inverted pendulum and its dynamics richness, in terms of nonlinearity, provide a nice apparatus to reproduce behaviors of analogous systems. In this way, it is useful to perform benchmark tests for new control approaches developed. In this paper, we address the main inverted pendulum problems: pendulum stabilization, tracking, and catching swing-up control. We show how robust recursive, control and filtering, techniques improve the system performance. They are developed to solve stochastic problems based on deterministic approaches, in order to decrease the worst influence of uncertainties. Experimental results of the proposed robust approach provide robust stability and performance despite parametric uncertainties, disturbances, and noise effects. 相似文献
55.
Wurster Marco Michel Marius May Marvin Carl Kuhnle Andreas Stricker Nicole Lanza Gisela 《Journal of Intelligent Manufacturing》2022,33(2):575-591
Journal of Intelligent Manufacturing - Remanufacturing includes disassembly and reassembly of used products to save natural resources and reduce emissions. While assembly is widely understood in... 相似文献
56.
Paolini Emilio De Marinis Lorenzo Cococcioni Marco Valcarenghi Luca Maggiani Luca Andriolli Nicola 《Neural computing & applications》2022,34(18):15589-15601
Neural Computing and Applications - Photonics-based neural networks promise to outperform electronic counterparts, accelerating neural network computations while reducing power consumption and... 相似文献
57.
Iovine Andrea Lops Pasquale Narducci Fedelucio de Gemmis Marco Semeraro Giovanni 《Journal of Intelligent Information Systems》2022,58(2):337-362
Journal of Intelligent Information Systems - Conversational Recommender Systems have received widespread attention in both research and practice. They assist people in finding relevant and... 相似文献
58.
Davide Masato Marco Sorgato Giovanni Lucchetta 《Materials and Manufacturing Processes》2017,32(16):1823-1830
Centrifugal casting is a technology used for manufacturing hybrid rocket paraffin grains. This technology helps avoiding voids formation inside the solid paraffin as it cools. Voids are formed because of air bubbles being entrapped while pouring and because the liquid wax shrinks by 17–19% upon cooling. In this work, the centrifugal casting process for the manufacturing of paraffin cylinders was prototyped at two different scales considering critical casting issues. The effects of process parameters (rotational speed, melt temperature, and flow rate) on the tensile properties of the manufactured grains were analyzed. The results of the optimization conducted at the lower scale (2.5?kg) were up scaled to manufacture 25?kg grains. The resulting mechanical properties complied with the design specifications, and they were better than those characterized from the gravity cast wax. A numerical model of growth and dissolution of bubbles during the process was then developed to predict the quality of the castings. The numerical results showed how increasing the mold rotational speed up to 1800?rpm reduced the removal time. However, compared to grains solidification time, the predicted removal times were much shorter, proving the advantage of centrifugal casting in counteracting voids formation. 相似文献
59.
In recent years, X-ray screening systems have been used to safeguard environments in which access control is of paramount importance. Security checkpoints have been placed at the entrances to many public places to detect prohibited items such as handguns and explosives. Human operators complete these tasks because automated recognition in baggage inspection is far from perfect. Research and development on X-ray testing is, however, ongoing into new approaches that can be used to aid human operators. This paper attempts to make a contribution to the field of object recognition by proposing a new approach called Adaptive Sparse Representation (XASR+). It consists of two stages: learning and testing. In the learning stage, for each object of training dataset, several patches are extracted from its X-ray images in order to construct representative dictionaries. A stop-list is used to remove very common words of the dictionaries. In the testing stage, test patches of the test image are extracted, and for each test patch a dictionary is built concatenating the ‘best’ representative dictionary of each object. Using this adapted dictionary, each test patch is classified following the Sparse Representation Classification methodology. Finally, the test image is classified by patch voting. Thus, our approach is able to deal with less constrained conditions including some contrast variability, pose, intra-class variability, size of the image and focal distance. We tested the effectiveness of our method for the detection of four different objects. In our experiments, the recognition rate was more than 97 % in each class, and more than 94 % if the object is occluded less than 15 %. Results show that XASR+ deals well with unconstrained conditions, outperforming various representative methods in the literature. 相似文献
60.
In this article, a new population-based algorithm for real-parameter global optimization is presented, which is denoted as self-organizing centroids optimization (SOC-opt). The proposed method uses a stochastic approach which is based on the sequential learning paradigm for self-organizing maps (SOMs). A modified version of the SOM is proposed where each cell contains an individual, which performs a search for a locally optimal solution and it is affected by the search for a global optimum. The movement of the individuals in the search space is based on a discrete-time dynamic filter, and various choices of this filter are possible to obtain different dynamics of the centroids. In this way, a general framework is defined where well-known algorithms represent a particular case. The proposed algorithm is validated through a set of problems, which include non-separable problems, and compared with state-of-the-art algorithms for global optimization. 相似文献