全文获取类型
收费全文 | 430篇 |
免费 | 38篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 13篇 |
综合类 | 1篇 |
化学工业 | 183篇 |
金属工艺 | 15篇 |
机械仪表 | 10篇 |
建筑科学 | 12篇 |
矿业工程 | 1篇 |
能源动力 | 9篇 |
轻工业 | 83篇 |
水利工程 | 1篇 |
石油天然气 | 1篇 |
无线电 | 9篇 |
一般工业技术 | 80篇 |
冶金工业 | 10篇 |
自动化技术 | 41篇 |
出版年
2024年 | 1篇 |
2023年 | 9篇 |
2022年 | 36篇 |
2021年 | 30篇 |
2020年 | 12篇 |
2019年 | 25篇 |
2018年 | 17篇 |
2017年 | 15篇 |
2016年 | 21篇 |
2015年 | 15篇 |
2014年 | 26篇 |
2013年 | 40篇 |
2012年 | 27篇 |
2011年 | 41篇 |
2010年 | 28篇 |
2009年 | 16篇 |
2008年 | 17篇 |
2007年 | 17篇 |
2006年 | 13篇 |
2005年 | 5篇 |
2004年 | 7篇 |
2003年 | 14篇 |
2002年 | 3篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 4篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1987年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有469条查询结果,搜索用时 46 毫秒
11.
Dr. Andrija Smelcerovic Dr. Jelena Lazarevic Katarina Tomovic Marija Anastasijevic Dr. Marko Jukic Dr. Gordana Kocic Dr. Marko Anderluh 《ChemMedChem》2019,14(5):514-521
Due to uncomfortable injection regimens of peptidic agonists of glucagon-like peptide-1 receptor (GLP-1R), orally available nonpeptide positive allosteric modulators (PAMs) of GLP-1Rs are foreseen as the possible future mainstream therapy for type 2 diabetes. Herein, current GLP-1R PAMs are reviewed. Based on the effectiveness and in silico predicted physicochemical properties, pharmacokinetics, and toxicity, possible candidates for further development as oral drugs were selected. The suggestion is that GLP-1R PAMs might be used orally alone or in combination with dipeptidyl peptidase-4 (DPP-4) inhibitors, which could offer an optimal treatment option next to metformin monotherapy in type 2 diabetes mellitus, or in a wider spectrum of indications. Quercetin acts as a GLP-1R PAM and DPP-4 inhibitor, and therefore, might be considered as a pioneering agent with a dual mechanism of action, in terms of GLP-1R positive allosteric modulation and DPP-4 inhibition for potentiating GLP-1 dependent effects. 相似文献
12.
Tijanić Ksenija Car-Pušić Diana Šperac Marija 《Neural computing & applications》2020,32(13):9343-9355
Neural Computing and Applications - Road construction projects on the territory of the Republic of Croatia are characterized by the overrun of planned costs. The experience of the contractor on... 相似文献
13.
14.
Nina Kobal Tjaa Kraovec Maja utar Marija Volk Borut Peterlin Marko Hawlina Ana Fakin 《International journal of molecular sciences》2021,22(4)
Mutations in rhodopsin gene (RHO) are a frequent cause of retinitis pigmentosa (RP) and less often, congenital stationary night blindness (CSNB). Mutation p.G90D has previously been associated with CSNB based on the examination of one family. This study screened 60 patients. Out of these 60 patients, 32 were affected and a full characterization was conducted in 15 patients. We described the clinical characteristics of these 15 patients (12 male, median age 42 years, range 8–71) from three families including visual field (Campus Goldmann), fundus autofluorescence (FAF), optical coherence tomography (OCT) and electrophysiology. Phenotypes were classified into four categories: CSNB (N = 3, 20%) sector RP (N = 3, 20%), pericentral RP (N = 1, 6.7%) and classic RP (N = 8, 53.3% (8/15)). The phenotypes were not associated with family, sex or age (Kruskal–Wallis, p > 0.05), however, cystoid macular edema (CME) was observed only in one family. Among the subjects reporting nyctalopia, 69% (22/32) were male. The clinical characteristics of the largest p.G90D cohort so far showed a large frequency of progressive retinal degeneration with 53.3% developing RP, contrary to the previous report. 相似文献
15.
16.
Marija Djokić Jelena Djuriš Ljiljana Solomun Kyriakos Kachrimanis Zorica Djurić Svetlana Ibrić 《Chemical Engineering Research and Design》2014
The purpose of this study was to investigate the influence of spiral jet-milling process on the physicochemical characteristics of α polymorphic active pharmaceutical ingredient, using Carbamazepine form III as a model drug, and taking into consideration Quality by Design (QbD) approach to pharmaceutical development. A 2(4-1) factorial screening design was implemented to identify the spiral jet-milling process variables that significantly affect the particle size distribution of milled samples. Diameter of injector nozzles, diameter of ring nozzles and air pressure were selected for further analysis using a 2(3-1) factorial experimental design. Particle size distribution of additional samples was determined, while physicochemical properties were examined by differential scanning calorimetry (DSC), hot-stage polarized microscopy (HSPM), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and compared to those of un-milled drug. The gathered results shown that applied experimental design approach is capable to predict material behavior and could help in better understanding of material behavior during jet-milling process. Created design space (DS) provides assurance of product quality, expressed as the powder particle sizes lower than 5 μm, as well as, in initial polymorph form existence after jet-milling through combination and interaction of input variables. 相似文献
17.
Viscoelastic properties of poly(ε‐caprolactone)/clay nanocomposites in solid and in melt state 下载免费PDF全文
Viscoelastic properties in solid and in melt state of poly(ε‐caprolactone), PCL, nanocomposites with organomodified clays (Cloisite30B and Cloisite15A) are thoroughly investigated. Although WAXD is insensitive to the difference in the nanocomposites structure, the melt rheology reveals pronounced differences between the two series. Melt yield stress values, obtained from fittings by the Carreau–Yasuda model, are used as a measure of partial exfoliation of the clay. Temperature dependence of the shift factors, used for time–temperature superposition of the modulus curves, yields similar values of the flow activation energies for all the samples. Temperature dependences of the dynamic modulus and loss factor of solid nanocomposites were correlated to the structural differences deduced from the melt rheology. The increase in the storage modulus is compared to the theoretical predictions from the Halpin–Tsai model. The effective aspect ratio obtained from this comparison agrees reasonably with the value estimated from the melt rheology. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 42896. 相似文献
18.
Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors 下载免费PDF全文
Dr. Gordon J. Florence Andrew L. Fraser Dr. Eoin R. Gould Elizabeth F. King Stefanie K. Menzies Dr. Joanne C. Morris Marie I. Thomson Dr. Lindsay B. Tulloch Marija K. Zacharova Prof. Dr. Terry K. Smith 《ChemMedChem》2016,11(14):1503-1506
Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern. They are a burden to human and animal health, having the most devastating effect on the world′s poorest countries. Building upon our previously reported triazole analogues, in this study we describe the synthesis and biological testing of other novel heterocyclic acetogenin‐inspired derivatives, namely 3,5‐isoxazoles, furoxans, and furazans. Several of these compounds maintain low‐micromolar levels of inhibition against Trypanosoma brucei, whilst having no observable inhibitory effect on mammalian cells, leading to the possibility of novel lead compounds for selective treatment. 相似文献
19.
Matilda Grüner Marija Horvati Milica Ga
i Mara Banovi 《Journal of the science of food and agriculture》1996,70(3):355-358
The phytic acid content and distribution of phosphorus during cereal flaking were determined as well as the level of some minerals, and the molar ratios of phytic acid: zinc were calculated. Statistical analyses showed that there were no differences in the amount of total phosphorus, between oats and wheat and between rye and barley. The phytic/non-phytic phosphorus ratio was about 3 in wheat and oats, about 2 in barley and about 13 in rye. The technological processing did not affect ( P< 0·05) phytic acid content. The molar ratio of phytic acid: zinc for the flakes was only slightly below that of the whole grain, indicating that the technological process, primarily a hydrothermal treatment and flaking, did not improve zinc availability. 相似文献
20.
Olesja Rogoza Kaspars Megnis Marija Kudrjavceva Aija Gerina-Berzina Vita Rovite 《International journal of molecular sciences》2022,23(3)
Somatostatin (SST) is a small peptide that exerts inhibitory effects on a wide range of neuroendocrine cells. Due to the fact that somatostatin regulates cell growth and hormone secretion, somatostatin receptors (SSTRs) have become valuable targets for the treatment of different types of neuroendocrine tumours (NETs). NETs are a heterogeneous group of tumours that can develop in various parts of the body, including the digestive system, lungs, and pituitary. NETs are usually slow growing, but they are often diagnosed in advanced stages and can display aggressive behaviour. The mortality rate of NETs is not outstandingly increased compared to other malignant tumours, even in the metastatic setting. One of the intrinsic properties of NETs is the expression of SSTRs that serve as drug targets for SST analogues (SSAs), which can delay tumour progression and downregulate hormone overproduction. Additionally, in many NETs, it has been demonstrated that the SSTR expression level provides a prognostic value in predicting a therapeutic response. Furthermore, higher a SSTR expression correlates with a better survival rate in NET patients. In recent studies, other epigenetic regulators affecting SST signalling or SSA–mTOR inhibitor combination therapy in NETs have been considered as novel strategies for tumour control. In conclusion, SST signalling is a relevant regulator of NET functionality. Alongside classical SSA treatment regimens, future advanced therapies and treatment modalities are expected to improve the disease outcomes and overall health of NET patients. 相似文献