Post-Digital Transdisciplinarity

Why are buildings generally credited to a single individual or firm, without acknowledging the numerous other participants in their creation? Marjan Colletti , founder and director of the REX|LAB robotic experimentation laboratory at the University of Innsbruck, reflects on the nature and implications of transdisciplinarity. With reference to REX|LAB's contribution to the highly collaborative 2015 show of Iris van Herpen's Quaquaversal ready-to-wear collection, he further considers the increasingly understated approach to technological presence in the post-digital age.     

Intelligent anticancer drug delivery performances of two poly(N-isopropylacrylamide)-based magnetite nanohydrogels

This article evaluates the anticancer drug delivery performances of two nanohydrogels composed of poly(N-isopropylacrylamide-co-itaconic anhydride) [P(NIPAAm-co-IA)], poly(ethylene glycol) (PEG), and Fe₃O₄ nanoparticles. For this purpose, the magnetite nanohydrogels (MNHGs) were loaded with doxorubicin hydrochloride (DOX) as a universal anticancer drug. The morphologies and magnetic properties of the DOX-loaded MNHGs were investigated using transmission electron microscopy (TEM) and vibrating–sample magnetometer (VSM), respectively. The sizes and zeta potentials (ξ) of the MNHGs and their corresponding DOX-loaded nanosystems were also investigated. The DOX-loaded MNHGs showed the highest drug release values at condition of 41?°C and pH 5.3. The drug-loaded MNHGs at physiological condition (pH 7.4 and 37?°C) exhibited negligible drug release values. In vitro cytotoxic effects of the DOX-loaded MNHGs were extensively evaluated through the assessing survival rate of HeLa cells using the MTT assay, and there in vitro cellular uptake into the mentioned cell line were examined using fluorescent microscopy and fluorescence-activated cell sorting (FACS) flow cytometry analyses. As the results, the DOX-loaded MNHG1 exhibited higher anticancer drug delivery performance in the terms of cytotoxic effect and in vitro cellular uptake. Thus, the developed MNHG1 can be considered as a promising de novo drug delivery system, in part due to its pH and thermal responsive drug release behavior as well as proper magnetite character toward targeted drug delivery.     

Discourses of town and country

There has arisen a great variety in the way we think about the relationship between town and country and in how those ideas are put into practical policy. The old certainties of the isolated town in a country setting have disappeared. By applying a discourse perspective we can understand and explain this variety better: different discourses can be identified within which people think about and act upon the relationship between town and country. An analysis in terms of discourses has certain advantages, apart from being a useful interpretive framework. For example, it admits the creative potential of ideas better than does an analysis in terms of power and interests, and it links theory and policy practice better than does an analysis in terms of paradigms. Finally, an analysis in terms of discourses suggests a way of generating new ideas for the theory about and the policy practice for the town–country relationship. Innovative ideas are likely to be found where two or more discourses meet and challenge each other. This is illustrated by reference to a large-scale programme which has been prepared for fundamental research into the relationship between town and country and new ideas for strategic policy.     

Grammar‐driven generation of domain‐specific language debuggers

Domain‐specific languages (DSLs) assist a software developer (or end‐user) in writing a program using idioms that are similar to the abstractions found in a specific problem domain. Tool support for DSLs is lacking when compared with the capabilities provided for standard general‐purpose languages (GPLs), such as Java and C++. For example, support for debugging a program written in a DSL is often non‐existent. The lack of a debugger at the proper abstraction level limits an end‐user's ability to discover and locate faults in a DSL program. This paper describes a grammar‐driven technique to build a debugging tool generation framework from existing DSL grammars. The DSL grammars are used to generate the hooks needed to interface with a supporting infrastructure constructed for an integrated development environment that assists in debugging a program written in a DSL. The contribution represents a coordinated approach to bring essential software tools (e.g. debuggers) to different types of DSLs (e.g. imperative, declarative, and hybrid). This approach hides from the end‐users the accidental complexities associated with expanding the focus of a language environment to include debuggers. The research described in this paper addresses a long‐term goal of empowering end‐users with development tools for particular DSL problem domains at the proper level of abstraction without depending on a specific GPL. Copyright © 2007 John Wiley & Sons, Ltd.     

Border adjustment for European emissions trading: Competitiveness and carbon leakage

Unilateral or sub-global policies to combat climate change are potentially sensitive to free-riding and carbon leakage. One way of dealing with carbon leakage and competitiveness is the imposition of border adjustment measures for competing imports, for example in the form of the obligation to importers of goods to purchase and surrender emissions allowances to the authorities when importing. In this paper, we explore some implications of border adjustment measures in the EU ETS, for sectors that might be subject to carbon leakage. We examine the implications of two variants of these measures on the competitiveness of these sectors and on the global environment with the help of a multi-sector, multi-region computable general equilibrium (CGE) model of the global economy. Our calculations suggest that border adjustment might reduce the sectoral rate of leakage of the iron and steel industry rather forcefully, but that the reduction would be less for the mineral products sector, including cement. The reduction of the overall or macro rate of leakage would be modest. So, from an environmental point of view border tax adjustments would not be a very effective policy measure, but might mainly be justified by considerations of sectoral competitiveness.     

Visualization and quantification of liquid water transport in softwood by means of neutron radiography

Liquid water uptake in an orthotropic, cellular, hierarchical and natural material namely wood is investigated using neutron radiography. During water uptake in wood, liquid does not move up as a regular front as uptake rates differ in latewood and earlywood. In addition, moisture is adsorbed by the cell wall, resulting in a swelling that influences the process of moisture transport in wood. The high sensitivity of neutron to hydrogen atoms enables an accurate determination of the change in moisture content in the wood at the growth ring scale. The analysis of the spatial and temporal change of water content distribution shows that liquid water transport has different characteristics, depending on the direction of uptake and initial moisture content state.Our results show that latewood cells play a more significant role in water uptake than earlywood cells and that ray tracheids also contribute to liquid transport. Latewood tracheids possess smaller cell lumens than earlywood cells that make them the preferential pathways for transport along the longitudinal direction. The process of liquid uptake is different in the radial and tangential directions as the path of the liquid is more intricate, involving also the rays and requiring more often traversing pits. In tangential direction, water uptake is occurring first in the latewood with a subsequent radial redistribution towards the earlywood. In radial direction, the growth ring boundary decreases the liquid transport rate, an indication that a significant portion of the rays are interrupted at that location. The moisture uptake rate in initially moist specimens is seen to be higher. Liquid transport leads to sorption and thus swelling of the specimens, which was dealt with by affine registration. Water uptake in wood cellular structure is a three-dimensional process that is controlled by the morphologic and sorption properties of the material at its different scales.     

Composition,antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil

The essential oil from underground parts of Ferula heuffelii from N.E. Serbia, was analysed using GC and GC–MS. The main compounds of the essential oil were elemicin (35.4%) and myristicin (20.6%). The essential oil exhibited the best antimicrobial activity against two strains of Candida albicans (MIC = 7.0 and 13.7 μg/ml), as well as against Micrococcus luteus (MIC = 13.7 μg/ml), Staphylococcus epidermidis (MIC = 17.6 μg/ml), Bacillus subtilis (MIC = 21.1 μg/ml) and Micrococcus flavus (MIC = 28.2 μg/ml). In the DPPH radical scavenging assay, essential oil showed substantial activity with SC₅₀ = 22.43 μl/ml. The essential oil was also tested for antispasmodic activity. It inhibited spontaneous contraction of isolated rat ileum dose-dependently, and at the concentration of 86.64 μg/ml exhibited 50% of the maximum effect of atropine. After incubation with 75.00 μg/ml of essential oil, acetylcholine did not induce contractions of ileum, and at 250.00 μg/ml, the essential oil almost completely abolished the spasmodic effect of potassium chloride (80 mM).     

Toward High Thermoelectric Performance of Thiophene and Ethylenedioxythiophene (EDOT) Molecular Wires

The design of thermoelectric materials for the efficient conversion of waste heat into electricity requires simultaneous tuning of their electrical and thermal conductance. A comparative theoretical study of electron and phonon transport in thiophene and ethylenedioxythiophene (EDOT) based molecular wires is performed. It is shown that modifying thiophene by substituting ethylenedioxy enhances the thermoelectric figure of merit ZT for molecules of the same length. Furthermore, it is demonstrated that the electrical conductance of EDOT‐based wires decays more slowly with length than that of thiophene‐based wires and that their thermal conductance is lower. The room‐temperature ZT of undoped EDOT is found to be rather low. However, doping of EDOT by the electron acceptor tolunenesulfunate increases the Seebeck coefficient and electrical conductance, while decreasing the thermal conductance, leading to a thermoelectric figure of merit as high as ZT = 2.4.     

Actor-based slicing techniques for efficient reduction of Rebeca models

Slicing is a program analysis technique which can be used for reducing the size of the model and avoid state space explosion in model checking. In this work a static slicing technique is proposed for reducing Rebeca models with respect to a property. For applying the actor-based slicing techniques, the Rebeca control flow graph (RCFG) and the Rebeca dependence graph (RDG) are introduced. We propose two different approaches for constructing the RDG, where each approach can be more effective under certain conditions. As the static slicing usually produces large slices, two other slicing-based reduction techniques, step-wise slicing and bounded slicing, are proposed as simple novel ideas. Step-wise slicing first generates slices that overapproximate the behavior of the original model and then refines it, and bounded slicing is based on the semantics of nondeterministic assignments in Rebeca. We also propose a static slicing algorithm for deadlock detection (in absence of any particular property). The efficiency of these techniques is checked by applying them to several case studies which are included in this paper. Similar techniques can be applied on the other actor-based languages.