Isothermal crystallization kinetics and morphology of PP/TiO2 nanocomposites using titanium n‐butoxide precursor

This study investigates the influence of the addition of TiO₂, obtained by hydrolysis–condensation reaction of titanium dioxide precursors, on the kinetics of polypropylene (PP) isothermal crystallization. The dispersion of nanoparticle and its relation to the degree of crystallinity by XRD was also investigated. The results indicated that the addition of the TiO₂ increased the degree of crystallinity of PP and its crystallization temperature. Likewise, the nucleation and crystal growth processes were also affected, as indicated by the TEM morphology, the Avrami kinetic model, and the optical microscopy, in which a nucleation effect was detected. POLYM. COMPOS. 36:517–526, 2015. © 2014 Society of Plastics Engineers     

Electrochemical Performance of Nd1.95NiO4+δ Cathode supported Microtubular Solid Oxide Fuel Cells

Nd_1.95NiO_4+δ (NNO) cathode supported microtubular cells were fabricated and characterized. This material presents superior oxygen transport properties in comparison with other commonly used cathode materials. The supporting tubes were fabricated by cold isostatic pressing (CIP) using NNO powders and corn starch as pore former. The electrolyte (GDC, gadolinia doped ceria based) was deposited by wet powder spraying (WPS) on top of pre‐sintered tubes and then co‐sintered. Finally, a NiO/GDC suspension was dip‐coated and sintered as the anode. Optimization of the cell fabrication process is shown. Power densities at 750 °C of ∼40 mWcm⁻² at 0.5V were achieved. These results are the first electrochemical measurements reported using NNO cathode‐supported microtubular cells. Further developments of the fabrication process are needed for this type of cells in order to compete with the standard microtubular solid oxide fuel cells (SOFC).     

Carrier effect on structure and properties of heat-treated poly(ethylene terephthalate) fibers. I. Thermal analysis and dynamic mechanical properties

Poly(ethylene terephthalate) (PET) fibers of different draw ratios (as spun and drawn 2.8×) were submitted to different heat settings. Subsequently, they were treated in benzoic acid solutions at different concentrations and for different times of exposition. The plas-ticizing effect on the morphology of these heat-setted fibers due to the different treatments in benzoic acid solutions was studied by differential scanning calorimetry (DSC) and dynamic and mechanical thermal analysis (DMTA). The DSC experiments revealed the appearance of a premelting peak (pm1) around 130°C, when the applied heat settings were carried out for 8 h in the presence of boiling water, and around 150–160°C for the dry heat setting for 7 h at 130°C followed by 1 h in the presence of boiling water. These premelting peaks have been associated with the melting of smaller and imperfect crystals present in the amorphous region. Also, the analysis of the main melting peaks revealed that the undrawn fiber presented a wider distribution of smaller crystals than the drawn one. Their subsequent treatments in the benzoic acid solutions revealed through the DSC thermograms that this first premelting peak tends to disappear as the concentration and time of benzoic acid treatment increase. Also, a new premelting peak (pm2) appears in the DSC thermograms at temperature around 180°C. It seems that a dislocation of the pm 1 peak is occurring towards higher temperatures and is being transformed in this new premelting peak. The DMTA revealed the appearance of an α_c transition in the temperature range from 140 to 160°C and this α_c transition seems to be related to the relaxations of the new crystallities formed due to the plasticization effect of the benzoic acid. Also, the second premelting peak seems to be related to the fusion of such crystals. Therefore, a complex change in the morphology of the studied PET fibers due to the benzoic acid action has been revealed. © 1996 John Wiley & Sons, Inc.     

The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut?

Some say that all diseases begin in the gut. Interestingly, this concept is actually quite old, since it is attributed to the Ancient Greek physician Hippocrates, who proposed the hypothesis nearly 2500 years ago. The continuous breakthroughs in modern medicine have transformed our classic understanding of the gastrointestinal tract (GIT) and human health. Although the gut microbiota (GMB) has proven to be a core component of human health under standard metabolic conditions, there is now also a strong link connecting the composition and function of the GMB to the development of numerous diseases, especially the ones of musculoskeletal nature. The symbiotic microbes that reside in the gastrointestinal tract are very sensitive to biochemical stimuli and may respond in many different ways depending on the nature of these biological signals. Certain variables such as nutrition and physical modulation can either enhance or disrupt the equilibrium between the various species of gut microbes. In fact, fat-rich diets can cause dysbiosis, which decreases the number of protective bacteria and compromises the integrity of the epithelial barrier in the GIT. Overgrowth of pathogenic microbes then release higher quantities of toxic metabolites into the circulatory system, especially the pro-inflammatory cytokines detected in osteoarthritis (OA), thereby promoting inflammation and the initiation of many disease processes throughout the body. Although many studies link OA with GMB perturbations, further research is still needed.     

Characterization of novel thermoresponsive poly(butylene adipate-co-terephthalate)/poly(N-isopropylacrylamide) electrospun fibers

Polymer Bulletin - In this work, electrospun fibers of poly(butylene adipate-co-terephthalate) (PBAT) and poly(N-isopropylacrylamide) (PNIPAAm) blends, PBAT/PNIPAAm, with different mass ratios,...     

Composites based on high-density polyethylene,polylactide and calcium carbonate: effect of calcium carbonate nanoparticles as co-compatibilizers

Polymer Bulletin - Investigating the compatibility mechanism of hybrid composites based on two polymers and one mineral nanofiller is a challenge that needs to be better understood. This study...     

Solid Tumors and Kinase Inhibition: Management and Therapy Efficacy Evolution

The increasing numbers of cancer cases worldwide and the exceedingly high mortality rates of some tumor subtypes raise the question about if the current protocols for cancer management are effective and what has been done to improve upon oncologic patients’ prognoses. The traditional chemo-immunotherapy options for cancer treatment focus on the use of cytotoxic agents that are able to overcome neoplastic clones’ survival mechanisms and induce apoptosis, as well as on the ability to capacitate the host’s immune system to hinder the continuous growth of malignant cells. The need to avert the highly toxic profiles of conventional chemo-immunotherapy and to overcome the emerging cases of tumor multidrug resistance has fueled a growing interest in the field of precision medicine and targeted molecular therapies in the last couple of decades, although relatively new alternatives in oncologic practices, the increased specificity, and the positive clinical outcomes achieved through targeted molecular therapies have already consolidated them as promising prospects for the future of cancer management. In recent years, the development and application of targeted drugs as tyrosine kinase inhibitors have enabled cancer treatment to enter the era of specificity. In addition, the combined use of targeted therapy, immunotherapy, and traditional chemotherapy has innovated the standard treatment for many malignancies, bringing new light to patients with recurrent tumors. This article comprises a series of clinical trials that, in the past 5 years, utilized kinase inhibitors (KIs) as a monotherapy or in combination with other cytotoxic agents to treat patients afflicted with solid tumors. The results, with varying degrees of efficacy, are reported.     

Methylmercury Causes Neurodegeneration and Downregulation of Myelin Basic Protein in the Spinal Cord of Offspring Rats after Maternal Exposure

Methylmercury (MeHg) is one of the most dangerous toxic pollutants spread throughout the earth. Chronic MeHg intoxication by contaminated food ingestion is the most common threat to human health, including impairment to the developing fetus. The present study aims at investigating the effects of maternal exposure to MeHg during gestation and lactation on the spinal cord of offspring. Pregnant rats received oral doses of MeHg (40 μg/kg/day) over a period of 42 days (21 gestation and 21 lactation). Control animals received the vehicle only. Total mercury concentration was measured in blood samples from offspring collected at the 41st postnatal day. Counting of motor neurons and immunoreactivity for myelin basic protein (MBP) were assessed in the spinal cords in both control and MeHg-intoxicated animals. Our results showed that MeHg promoted an increase in blood Hg levels. In addition, it caused a reduction in the number of spinal cord motor neurons as well as decreased MBP immunoreactivity in the cervical, thoracic and lumbar segments. Our present findings suggest that MeHg intoxication during rat pregnancy and lactation is associated with a pattern of motor neuron degeneration and downregulation of myelin basic protein in different segments of a developing spinal cord. Further studies are needed to establish the effect of MeHg intoxication in both young and adult rats.     

Theoretical model of a drying system including turbulence aspects

Biological products contain high moisture content in the harvest period. Such moisture could cause their deterioration in storage. Drying is an interesting solution to keep the quality of these products. Generally, drying process is based on contact of a dry air phase with a wet solid. A theoretical model was developed to describe the dynamic behavior of a forced convection drying process. This model takes into account the entire dynamic phenomenon including turbulence, diffusivity and tortuosity effects. Only the mass transfer of water molecules during vaporization was referred to as an empirical expression. The model thus strongly build, was compared to Thompson’s empirical model. Corn grain was used in the validating process. Transient temperature and water content results are presented.     

Characterization of palladium supported on sulfated zirconia catalysts by DRIFTS, XAS and n-butane isomerization reaction in the presence of hydrogen

Palladium supported on sulfated zirconia (PdSZ) has been characterized by the n-butane isomerization reaction in the presence of hydrogen, X-ray absorption spectroscopy (XAS) and diffuse reflectance Fourier transform infrared spectroscopy (DRIFTS) of adsorbed carbon monoxide. Catalyst calcination at 873 K followed by hydrogen reduction at 513 K results in the formation of 30–40 Å Pd metal clusters, but the surface can only weakly adsorb CO, though stronger than Pd-free, sulfated zirconia catalysts. In the presence of hydrogen, PdSZ has a lower n-butane isomerization activity than SZ, and the Pd function cannot stabilize the reaction at low H₂/n-butane ratios.