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21.
Knowledge visualization for evaluation tasks 总被引:1,自引:1,他引:0
Although various methods for the evaluation of intelligent systems have been proposed in the past, almost no techniques are
present that support the manual inspection of knowledge bases by the domain specialist. Manual knowledge base inspection is
an important and frequently applied method in knowledge engineering. Since it can hardly be performed in an automated manner,
it is a time-consuming and costly task. In this paper, we discuss a collection of appropriate visualization techniques that
help developers to interactively browse and analyze the knowledge base in order to find deficiencies and semantic errors in
their implementation. We describe standard visualization methods adapted to specifically support the analysis of the static
knowledge base structure, but also of the usage of knowledge base objects such as questions or solutions. Additionally, we
introduce a novel visualization technique that supports the validation of the derivation and interview behavior of a knowledge
system in a semi-automatic manner. The application of the presented methods was motivated by the daily practice of knowledge
base development. 相似文献
22.
In list-method directed forgetting, participants are cued to intentionally forget a previously studied list while remembering a subsequently presented 2nd list. Results from prior research are inconclusive on whether older adults show deficits in this type of task. In 3 experiments, the authors reexamined the issue and compared younger and older adults' responsiveness to the forget cue. Across the experiments, the forget cue was varied within and between participants, the 2 lists were unrelated and related to each other, and recall of the lists was required simultaneously and successively. In none of the 3 experiments did any age-related difference in directed forgetting performance emerge. List-method directed forgetting is assumed to reflect retrieval inhibition. The present results thus challenge the proposal of a general inhibitory deficit in older adults' memory performance. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
23.
Martina Bečvářová 《NTM》2004,12(1):40-48
The paper describes the Czech project in the history of mathematics which was initiated at the Faculty of Mathematics and
Physics of Charles University in Prague at the end of the eighties of the 20th century. Its main aim is to map the development
of mathematical research in the Czech lands in the second half of the nineteenth and the first half of the twentieth century.
The main result of this project is the production of monographs. These chart out the life and work of some prominent Czech
personalities-mathematicians who have had substantial influence on the development of Czech mathematics. The aim of the project,
the structure of the monographs and the general method are discussed in the paper. 相似文献
24.
Dr. Vladimir O. Talibov Dr. Edoardo Fabini Edward A. FitzGerald Dr. Daniele Tedesco Daniela Cederfeldt Martin J. Talu Moira M. Rachman Filip Mihalic Dr. Elisabetta Manoni Dr. Marina Naldi Dr. Paola Sanese Dr. Giovanna Forte Dr. Martina Lepore Signorile Prof. Xavier Barril Dr. Cristiano Simone Prof. Manuela Bartolini Dr. Doreen Dobritzsch Dr. Alberto Del Rio Prof. U. Helena Danielson 《Chembiochem : a European journal of chemical biology》2021,22(9):1597-1608
SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its biochemistry and potential as a therapeutic target, a set of drug-like compounds was screened in a biosensor-based competition assay. Diperodon was identified as an allosteric ligand; its R and S enantiomers were isolated, and their affinities to SMYD3 were determined (KD=42 and 84 μM, respectively). Co-crystallization revealed that both enantiomers bind to a previously unidentified allosteric site in the C-terminal protein binding domain, consistent with its weak inhibitory effect. No competition between diperodon and HSP90 (a known SMYD3 interaction partner) was observed although SMYD3–HSP90 binding was confirmed (KD=13 μM). Diperodon clearly represents a novel starting point for the design of tool compounds interacting with a druggable allosteric site, suitable for the exploration of noncatalytic SMYD3 functions and therapeutics with new mechanisms of action. 相似文献
25.
Martina Halasova Zdenek Chlup Adam Strachota Martin Cerny Ivo Dlouhy 《Journal of the European Ceramic Society》2012,32(16):4489-4495
The presented work describes mechanical properties of materials prepared by the pyrolysis of polysiloxane resins. The polymeric precursors have different chemical composition. Materials under investigation are predetermined for high temperature resistant applications usually in composite form, i.e. accompanied by some reinforcement. Instrumented hardness tests were employed for material characterisation. The Vickers hardness, Martens hardness and indentation elastic modulus were the key parameters, determined either from the standard optical technique or load–indentation depth curves. The influence of mechanical properties on the monomers ratio was established. The exposition to the temperature between 1200 °C and 1500 °C in air was applied to observe damage caused by these severe conditions. 相似文献
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We theoretically compare the scattering and near field of nanoparticles from different types of materials, each characterized by specific optical properties that determine the interaction with light: metals with their free charge carriers giving rise to plasmon resonances, dielectrics showing zero absorption in wide wavelength ranges, and semiconductors combining the two beforehand mentioned properties plus a band gap. Our simulations are based on Mie theory and on full 3D calculations of Maxwell’s equations with the finite element method. Scattering and absorption cross sections, their division into the different order electric and magnetic modes, electromagnetic near field distributions around the nanoparticles at various wavelengths as well as angular distributions of the scattered light were investigated. The combined information from these calculations will give guidelines for choosing adequate nanoparticles when aiming at certain scattering properties. With a special focus on the integration into thin film solar cells, we will evaluate our results. 相似文献