Intuitionistic fuzzy rough sets: at the crossroads of imperfect knowledge

Abstract: Just like rough set theory, fuzzy set theory addresses the topic of dealing with imperfect knowledge. Recent investigations have shown how both theories can be combined into a more flexible, more expressive framework for modelling and processing incomplete information in information systems. At the same time, intuitionistic fuzzy sets have been proposed as an attractive extension of fuzzy sets, enriching the latter with extra features to represent uncertainty (on top of vagueness). Unfortunately, the various tentative definitions of the concept of an ‘intuitionistic fuzzy rough set’ that were raised in their wake are a far cry from the original objectives of rough set theory. We intend to fill an obvious gap by introducing a new definition of intuitionistic fuzzy rough sets, as the most natural generalization of Pawlak's original concept of rough sets.     

Diffusion-limited evaporation of thin polar liquid films

The stability of evaporating very thin films of a polar liquid is investigated. The microscopic interaction with the substrate and capillarity are taken into account in a lubrication equation. The stability of a flat interface is studied when evaporation is limited by the diffusion of the vapour in the gas phase. The evaporation rate is computed and evaporation is shown to be stabilizing. A stability phase diagram is obtained. A weakly nonlinear analysis leads to a film-thickness amplitude equation that is non local in space. Physical consequences of the results are eventually discussed.     

Reducing energy requirement for drying of beet-pulp: Simulation of energy integration between superheated steam and air drying systems

Beet-pulp dehydration in the sugar industry is a highly energy intensive unit operation. Producing 1?kg of dried beet-pulp requires ～2–3?kg of water to be removed. The cost saving is a real challenge in sugar factory as the current dryers are underperforming (around 3?MJ/kg of water evaporated) because the heat recovery is limited and only a small proportion of dryer exhaust can be reused. The aim of this study was to investigate by simulation the energy efficiency of an independent multistage drying method that combines superheated steam drying (SHSD) and hot air drying (AD). Two case studies awarding the two types of energy coupling (AD then SHSD or SHSD then AD) are presented and compared. An approach of optimization is developed from energy balance. A number of operating parameters of the two drying configurations are investigated using sensitivity analysis. It proves that both cases allow an energy economy around 40% compared to the conventional dryer. Nevertheless, the SHSD-AD plant may present more benefits for a better quality product.     

Survey of 1012 moldy dwellings by culture fungal analysis: Threshold proposal for asthmatic patient management

Different countries have tried to define guidelines to quantify what levels of fungi are considered as inappropriate for housing. This retrospective study analyzes indoor fungi by cultures of airborne samples from 1012 dwellings. Altogether, 908 patients suffering from rhinitis, conjunctivitis, and asthma were compared to 104 controls free of allergies. Portuguese decree law no 118/2013 (PDL118), ANSES (a French environmental and health agency) recommendations, and health regulations of Besançon University Hospital were applied to determine the rates of non‐conforming dwellings, which were respectively 55.2%, 5.2%, and 19%. Environmental microbiological results and medical data were compared. The whole number of colonies per cubic meter of air was correlated with asthma (P < 0.001) and rhinitis (P = 0.002). Sixty‐seven genera and species were detected in bedrooms. Asthma was correlated to Aspergillus versicolor (P = 0.004) and Cladosporium spp. (P = 0.02). Thresholds of 300 cfu/m³ for A. versicolor or 495 cfu/m³ for Cladosporium spp. are able to discriminate 90% of the asthmatic dwellings. We propose a new protocol to obtain an optimal cost for indoor fungi surveys, excluding surface analyses, and a new guideline to interpret the results based on >1000 cfu/m³ of whole colonies and/or above threshold levels for A. versicolor or Cladosporium spp.     

Patterns in melanocytic lesions: impact of the geometry on growth and transport inside the epidermis

In glabrous skin, nevi and melanomas exhibit pigmented stripes during clinical dermoscopic examination. They find their origin in the basal layer geometry which periodically exhibits ridges, alternatively large (limiting ridges) and thin (intermediate ridges). However, nevus and melanoma lesions differ by the localization of the pigmented stripes along furrows or ridges of the epidermis surface. Here, we propose a biomechanical model of avascular tumour growth which takes into account this specific geometry in the epidermis where both kinds of lesions first appear. Simulations show a periodic distribution of tumour cells inside the lesion, with a global contour stretched out along the ridges. In order to be as close as possible to clinical observations, we also consider the melanin transport by the keratinocytes. Our simulations show that reasonable assumptions on melanocytic cell repartition in the ridges favour the limiting ridges of the basal compared with the intermediate ones in agreement with nevus observations but not really with melanomas. It raises the question of cell aggregation and repartition of melanocytic cells in acral melanomas and requires further biological studies of these cells in situ.     

Environmentally Sustainable Construction: Knowledge and Learning in London Planning Departments

Environmentally sustainable construction is now recognised as a significant element of the broader sustainable development agenda and planners are being called upon to play a role in delivering more sustainable patterns of construction and development. This puts particular demands on the knowledge resources of planners since knowledge is implicated in the power relations between planners and developers. This paper examines the interrelationship between knowledge of environmentally sustainable construction and practice in planning departments. Drawing on a survey of and interviews with planners in London, it discusses the construction of knowledge within the dynamics of planning organisations and the potential for learning to promote a more sustainable built environment. Wenger's concept of communities of practice frames the analysis, alongside consideration of the translation of knowledge into bureaucratic and usable forms and the role of knowledge brokers in this process.     

ASGPR‐Mediated Uptake of Multivalent Glycoconjugates for Drug Delivery in Hepatocytes

Liver cells are an essential target for drug delivery in many diseases. The hepatocytes express the asialoglycoprotein receptor (ASGPR), which promotes specific uptake by means of N‐acetylgalactosamine (GalNAc) recognition. In this work, we designed two different chemical architectures to treat Wilson's disease by intracellular copper chelation. Two glycoconjugates functionalized with three or four GalNAc units each were shown to enter hepatic cells and chelate copper. Here, we studied two series of compounds derived from these glycoconjugates to find key parameters for the targeting of human hepatocytes. Efficient cellular uptake was demonstrated by flow cytometry using HepG2 human heptic cells that express the human oligomeric ASGPR. Dissociation constants in the nanomolar range showed efficient multivalent interactions with the receptor. Both architectures were therefore concluded to be able to compete with endogeneous asialoglycoproteins and serve as good vehicles for drug delivery in hepatocytes.     

A dynamic programming approach for economic optimisation of lifetime-extending maintenance,renovation, and replacement of public infrastructure assets under differential inflation

In the next decades, many public infrastructure assets will reach the end of their life that they were originally designed for. Replacement costs are high, and therefore increasing effort is put into lifetime-extending maintenance, including major overhauls and renovations. A key question is whether the investments in lifetime-extending maintenance justify the postponement of a full replacement. This question becomes more complicated when future life cycle cash flows are non-repeatable. Differential inflation and technological change, including multiple intervention strategies to maintain a desired functionality, cause such non-repeatability. In this case, classic replacement analysis techniques will not suffice in answering this question. Literature demonstrates that case-specific modelling with dynamic or linear programming techniques is required to find economic optimisation. However, such literature primarily addresses replacement interval optimisation of new investments within relative short time horizons, whereas the current research develops a nested dynamic programming (DP) approach for typical ageing infrastructure assets over long service life periods. The model can deal with multiple and various successive intervention strategies and addresses differential inflation and age-related cost increases. Finally, it is shown in an infrastructure case study that this DP approach leads to a better decision in comparison to the application of classical replacement techniques.