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11.
Hala Skayneh Batoul Jishi Rita Hleihel Maguy Hamie Rana El Hajj Carine Deleuze-Masquefa Pierre-Antoine Bonnet Marwan El Sabban Hiba El Hajj 《International journal of molecular sciences》2022,23(7)
Nucleophosmin-1 (NPM1) is a pleiotropic protein involved in numerous cellular processes. NPM1 shuttles between the nucleus and the cytoplasm, but exhibits a predominant nucleolar localization, where its fate and functions are exquisitely controlled by dynamic post-translational modifications (PTM). Sentrin/SUMO Specific Peptidase 3 (SENP3) and ARF are two nucleolar proteins involved in NPM1 PTMs. SENP3 antagonizes ARF-mediated NPM1 SUMOylation, to promote ribosomal biogenesis. In Acute Myeloid Leukemia (AML), NPM1 is frequently mutated, and exhibits an aberrant cytoplasmic localization (NPM1c). NPM1c mutations define a separate AML entity with good prognosis in some AML patients, rendering NPM1c as a potential therapeutic target. SENP3-mediated NPM1 de-SUMOylation induces resistance to therapy in NPM1c AML. Here, we demonstrate that the imidazoquinoxaline EAPB0503 prolongs the survival and results in selective reduction in the leukemia burden of NPM1c AML xenograft mice. Indeed, EAPB0503 selectively downregulates HDM2 expression and activates the p53 pathway in NPM1c expressing cells, resulting in apoptosis. Importantly, we unraveled that NPM1c expressing cells exhibit low basal levels of SUMOylation paralleled with high SENP3 and low ARF basal levels. EAPB0503 reverted these molecular players by inducing NPM1c SUMOylation and ubiquitylation, leading to its proteasomal degradation. EAPB0503-induced NPM1c SUMOylation is concurrent with SENP3 downregulation and ARF upregulation in NPM1c expressing cells. Collectively, these results provide a strong rationale for testing therapies modulating NPM1c post-translational modifications in the management of NPM1c AML. 相似文献
12.
The present study was carried out to asses performance of a Pd-monolith downflow bubble column (DBC) reactor, and compare it with that of the slurry and the fixed bed DBC. The selective hydrogenation of butyne-1,4-diol to cis-2-butene-1,4-diol over palladium catalyst was chosen as a model reaction. In principle, the monolith DBC allowed the reaction to take place under kinetic control regime. Comparison with DBC employing 5% Pd/C powder and 1% Pd-on-Raschig ring catalysts revealed a better performance of the monolith DBC (1% Pd loading) with advantage of smaller reaction volume and intensified reaction rate. In the monolith DBC, improved hydrogen transport was possible, as the interface between bubbles and the channel wall was very thin, thus, the length of the diffusion path was very short. In addition, the interfacial surface area at both gas–liquid and liquid–solid interface in the monolith was also very high. The reaction kinetics was well represented by the Langmuir–Hinshelwood mechanism. As an alternative to conventional three-phase reactors, the monolith DBC was simple due to its inherent characteristic operation and no specially designed device. 相似文献
13.
Khaled Sennah Marwan Saliba Nidal Jaalouk 《Journal of Constructional Steel Research》2009,65(5):1034-1042
The Canadian Standard for Antenna Towers and Antenna Supporting Structures, CSA-S37-01, specifies expressions for the compressive resistance of solid rounds based on the Structural Stability Research Council (SSRC) Column Curves for non-solid-round members and the results from experimental investigations on the compressive resistance of solid rounds carried out back to 1965. Similar Standard in USA (TIA/EIA-222-G.0) specifies design criteria for such members as derived from the superseded AISC-LRFD-94 Standard, which is independent of the shape of the member cross-section. The European Standard, Eurocode 3, provides column curves for the compressive resistance of various structural steel members, and assumes the applicability of one of them to solid rounds. As such, it is necessary to conduct an experimental study on solid round stress-relieved steel members to refine the available design equations for such members. This paper provides a summary of the literature review on solid rounds as well as a recent test program conducted on stress-relieved steel solid rounds. Correlation between the results from these tests and the current practice for the design of solid rounds is investigated. The paper concludes with a proposed compressive resistance equation for economical design of such members. 相似文献
14.
15.
Parental and familial factors and their association with adolescents’ mental health were examined among former Soviet Union (FSU) immigrants and nonimmigrants in Israel. Questionnaires regarding parental control, inconsistency, and rejection, in addition to adolescent–family connectedness and psychological disorders, were administered to 83 FSU immigrants and 106 nonimmigrant adolescents. According to the results, FSU adolescents are less connected to their families, experience their parents as less warm and more inconsistent in their childrearing behavior, report that their mothers subject them to a higher level of control, and the psychological disorders among them are more widespread than among nonimmigrant adolescents. Maternal control, maternal temporal inconsistency, and maternal and paternal rejection were associated with psychological disorders only among nonimmigrant adolescents. No such association was found among FSU adolescents, suggesting that FSU mental health problems are associated with immigration and cultural and social factors, rather than parental and familial factors. A comprehensive intervention program is required to provide support and assistance to help immigrants overcome their psychological distresses. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
16.
We have evaluated the extent of public concerns about water management in the Palestinian Territory (PT) through a survey of the main Palestinian newspaper over the last thirteen years divided in three periods: pre (1984–1987), during (1988–1991), and post national uprising period (1992–1996). The public concern in the PT about various water management aspects was clear and influenced by the prevailing political conditions indicating (1) poor concerns in the first and second period where full Israeli military control of the PT and harsh practices prevailed with relatively more emphasis on regional water issues and (2) extensive-strong concerns in the third period when the peace process started and a partial lift of some of the Israeli water practices took place, along with an increased freedom in expressing public concerns which was granted with more emphasis on local issues and problems. Lack and limitation of water available to Palestinians, alternative solutions, and water quality and pollution control constituted the overwhelming majority of the topics of concern to the public for the three periods studied. Palestinian concerns were always greater than regional ones for the three periods and all of the topics considered. Public concern in the PT about all other water management aspects was poor and negligible especially in the first two periods. A massive increase in public concern has been observed in the third period in which the public expressed their concern over most water management aspects, indicating a possible change in public attitude toward water and water management and reflecting the change of the political status by the start of the peace process and the signing of the peace agreements. 相似文献
17.
18.
Fadi K. Abu-Farha Marwan K. Khraisheh 《Journal of Materials Engineering and Performance》2007,16(2):142-149
The simplest test in characterizing the behavior of superplastic materials is the uniaxial tensile test. Since superplasticity
is achieved at relatively high temperatures, heat involvement adds so many unpredictable problems to the simplest testing
technique. In spite of the vast number of research activities directed towards studying the various aspects of superplastic
deformation, there is a lack of a standardized testing procedure that can tackle the various issues associated with high temperature
testing. In this work, we attempt to shed some light on the controversial issues associated with high temperature superplastic
testing. The effects of various testing procedures and parameters on the accuracy of the results are investigated. We address
the issues related to gripping and test sample geometry, heat and temperature effects, and comment on the available testing
and analysis procedures. We hope that this study highlights the urgent need to develop a standardized testing approach that
takes into account all the important issues affecting high temperature testing.
This article was presented at the AeroMat Conference, International Symposium on Superplasticity and Superplastic Forming
(SPF) held in Seattle, WA, June 6–9, 2005. 相似文献
19.
Research efforts have reported on the ability of carbon nanotubes (CNTs) to enhance the stiffness and strength of carbon fiber composites. Systematic design of blast-resistant composites requires considering CNTs–carbon composites characteristics and the uncertainty of blast events. This article suggests a systematic reliability-based design approach where system reliability is used to compute the probability of failure of a composite laminate. A case study for the design of a five-layer composite laminate incorporating CNTs and subjected to uncertain blast event is demonstrated. 0.5–1% CNTs contents by weight seem capable of significantly reducing the composite probability of failure during blast. 相似文献
20.
Measuring the I–V characteristics is of high importance since it can be considered as a quality and performance certificate for each PV generator. The most precise and inexpensive measuring method is represented in capacitor charging by the PV generator. Using the equivalent circuit of the PV generator with a capacitor as load and applying transient analysis on the circuit, we obtain the capacitor charging voltage and current as a function of time, as well as their differentials as a function of short circuit current and capacitor size. The derived equations facilitate the calculation of proper capacitance size for measuring the I–V characteristics, and considers the acquisition speed of the measuring system as demonstrated through two measurement samples in this paper. The capacitor size is directly and indirectly proportional to the short circuit current and open circuit voltage of the PV generator, respectively. Accordingly, the paper presents a capacitance calculation chart, which enables selecting the correct capacitance for measuring the I–V characteristics by a computerized data acquisition system. 相似文献