Structural Changes of Scandia-Doped Zirconia Solid Solutions: Rietveld Analysis and Raman Scattering

Powder X-ray diffractometry (XRD) and Raman scattering measurements were used to study the structural changes of compositionally homogeneous metastable ZrO₂ solid solutions induced by ScO_1.5 doping. The crystal structures of monoclinic, tetragonal, cubic, and rhombohedral (Sc₂Zr₇O₁₇, ß-phase) solid-solution phases have been refined by using the Rietveld analysis of the XRD data at room temperature of arc-melted ZrO₂- X ScO_1.5 ( X = 0, 2, …, 20, and 22 mol%) samples. The results can be interpreted as indicating that the structures of the monoclinic and tetragonal phases approach those of the tetragonal and cubic phases, respectively, by ScO_1.5 doping. Raman scattering, as well as XRD, was useful to investigate the phase assemblage. Moreover, we could obtain Raman spectra of the ß-phase probably for the first time.     

Application of an Ion-Packing Model Based on Defect Clusters to Zirconia Solid Solutions: I, Modeling and Local Structure of Solid Solutions

Oxygen vacancies can be introduced into zirconia solid solution ZrO₂–MO _u ( u = 1 and 1.5) to maintain electroneutrality. Recently, the local structures around Zr⁴⁺ and M^{2 u +} ions in ZrO₂–MO _u solid solutions have been studied through EXAFS spectroscopy, diffuse scattering analysis, and single-crystal structure analysis. The present study constructs an ion-packing model for zirconia solid solutions based on some defect cluster models. The decrease of cell volume with the occurrence of vacancies is assumed to be expressed by decreasing the coordination number (CN) of cations around the vacancy. The distribution of CNs in a solid solution was calculated from a certain defect cluster model. The average interatomic distances, the average CN, and the short-range order parameters were calculated using this distribution of CNs. The local structures calculated from the model were compared with experimental data in the systems ZrO₂–MO_1.5 (M = Y, Gd, Yb, and Ca). In the ZrO₂–YO_1.5 system, the r (s–O) interatomic distance, where s represents Zr⁴⁺ or Y³⁺ and O represents O²⁻, decreased with Y content and therefore vacancy content. The probability of finding Y³⁺ around a vacancy increases with increasing yttria content from a comparison of the calculated results with the ones from recent EXAFS studies. The present model can qualitatively explain compositional and size dependences of the dopant on various local structures.     

Void formation in 10Cr-2Mo ferritic steel irradiated in HFIR

Microstructural evolution of a 10Cr-2Mo ferritic steel was investigated after irradiation in the High Flux Isotope Reactor (HFIR) at 500°C and doses up to 57 dpa. About 300 appm of helium was also produced after 57 dpa because the steel contained 1 wt% Ni. Many tiny helium bubbles were observed in a specimen irradiated to 34 dpa, either inside of or adjacent to particles of radiation-produced x- and Laves-phase precipitates. By contrast, after 57 dpa many of the tiny bubbles had developed into larger voids. Most of the voids were associated with radiation-induced x-phase particles.     

Repeated temperature modulation epitaxy for p-type doping and light-emitting diode based on ZnO.

Since the successful demonstration of a blue light-emitting diode (LED), potential materials for making short-wavelength LEDs and diode lasers have been attracting increasing interest as the demands for display, illumination and information storage grow. Zinc oxide has substantial advantages including large exciton binding energy, as demonstrated by efficient excitonic lasing on optical excitation. Several groups have postulated the use of p-type ZnO doped with nitrogen, arsenic or phosphorus, and even p-n junctions. However, the choice of dopant and growth technique remains controversial and the reliability of p-type ZnO is still under debate. If ZnO is ever to produce long-lasting and robust devices, the quality of epitaxial layers has to be improved as has been the protocol in other compound semiconductors. Here we report high-quality undoped films with electron mobility exceeding that in the bulk. We have used a new technique to fabricate p-type ZnO reproducibly. Violet electroluminescence from homostructural p-i-n junctions is demonstrated at room-temperature.     

Piezoelectric unimorph microactuator arrays for single-crystal silicon continuous-membrane deformable mirror

Micromachined deformable mirror technology can boost the imaging performance of an otherwise nonrigid, lower-quality telescope structure. This paper describes the optimization of lead zirconium titanate (PZT) unimorph membrane microactuators for deformable mirrors. PZT unimorph actuators consisting of a variety of electrode designs, silicon-membrane thickness, and membrane sizes were fabricated and characterized. A mathematical model was developed to accurately simulate the membrane microactuator performance and to aid in the optimization of membrane thicknesses and electrode geometries. Excellent agreement was obtained between the model and the experimental results. Using the above approach, we have successfully demonstrated a 2.5-mm-diameter PZT unimorph actuator. A measured deflection of 5 /spl mu/m was obtained for 50 V applied voltage. Complete deformable mirror structures consisting of 10-/spl mu/m-thick single-crystal silicon mirror membranes mounted over the aforementioned 4/spl times/4 4 PZT unimorph membrane microactuator arrays were designed, fabricated, assembled, and optically characterized. The fully assembled deformable mirror showed an individual pixel stroke of 2.5 /spl mu/m at 50 V actuation voltage. The deformable mirror has a resonance frequency of 42 kHz and an influence function of approximately 25%.     

Prediction of major depression and dysthymia from CES-D scores among ethnic minority adolescents

Two tumour cell clones, 6D1 and 4C2 cells, which are defective both in the major histocompatibility gene complex (MHC) class I expression and in the endogenous antigen presentation, are recovered with interferon (IFN)-gamma treatment. The present study describes the ultrastructure of these cells by using scanning and transmission electron microscopy in relation to the effect of IFN-gamma treatment. The general morphology of these cells was found to be similar to each other and comparable to that of a tumour cell clone, 4A1 cells, of the same origin, normal in MHC class I expression; they exhibited a fibroblast-like appearance and had many blebs on all the cell surfaces, with desmosome-like junctions between cells. On IFN-gamma treatment, surface fine blebs appeared less, and mitochondria became more densely stained. Expression of MHC class I molecules on the cell surface was much higher in the IFN-gamma treated 6D1 and 4C2 cells than in untreated cells, when estimated by immunoelectron microscopy. The addition of an epitope peptide to these cells did not enhance the class I expression, which differed from other antigen presentation-defective cells such as RMA-S cells, nor change the cell surface morphology.     

Simultaneous measurements of specific heat and total hemispherical emissivity of chromel and alumel by a transient calorimetric technique

Using a transient calorimetric technique, the specific heat and total hemispherical emissivity of chromel and alumel were measured simultaneously in the temperature range 360–760 K. Two types of specimens for each material were prepared. To obtain reliable experimental values of specific heat and total hemispherical emissivity, an expression for the time history of the temperature of the specimens was developed; this expression is accurate over the whole temperature range. An error analysis is made and the uncertainty (the total error) in the values of specific heat and total hemispherical emissivity is estimated to be 3.1% for the well-designed specimens.

     

Capability of Utilizing CYP3A5 Polymorphisms to Predict Therapeutic Dosage of Tacrolimus at Early Stage Post-Renal Transplantation

While CYP3A5 polymorphisms are used to predict the initial dosage of tacrolimus therapy, the predictive capability of genetic information for dosing at early stage post-renal transplantation is unknown. We investigated the influence of polymorphisms over time. An initial oral dose of modified-release once-daily tacrolimus formulation (0.20 mg/kg) was administered to 50 Japanese renal transplant patients every 24 h. Stepwise multiple linear regression analysis for tacrolimus dosing was performed each week to determine the effect of patient clinical characteristics. The dose-adjusted trough concentration was approximately 70% higher for patients with the CYP3A5*3/*3 than patients with the CYP3A5*1 allele before the second pre-transplantation tacrolimus dose (0.97 (0.78–1.17) vs. 0.59 (0.45–0.87) ng/mL/mg; p < 0.001). The contribution of genetic factors (CYP3A5*1 or *3) for tacrolimus dosing showed increased variation from Day 14 to Day 28 after transplantation: 7.2%, 18.4% and 19.5% on Days 14, 21 and 28, respectively. The influence of CYP3A5 polymorphisms on the tacrolimus maintenance dosage became evident after Day 14 post-transplantation, although the tacrolimus dosage was determined based only on patient body weight for the first three days after surgery. Tacrolimus dosage starting with the initial administration should be individualized using the CYP3A5 genotype information.     

Real-Time Amplitude and Phase Imaging of Optically Opaque Objects by Combining Full-Field Off-Axis Terahertz Digital Holography with Angular Spectrum Reconstruction

Terahertz digital holography (THz-DH) has the potential to be used for non-destructive inspection of visibly opaque soft materials due to its good immunity to optical scattering and absorption. Although previous research on full-field off-axis THz-DH has usually been performed using Fresnel diffraction reconstruction, its minimum reconstruction distance occasionally prevents a sample from being placed near a THz imager to increase the signal-to-noise ratio in the hologram. In this article, we apply the angular spectrum method (ASM) for wavefront reconstruction in full-filed off-axis THz-DH because ASM is more accurate at short reconstruction distances. We demonstrate real-time phase imaging of a visibly opaque plastic sample with a phase resolution power of λ/49 at a frame rate of 3.5 Hz in addition to real-time amplitude imaging. We also perform digital focusing of the amplitude image for the same object with a depth selectivity of 447 μm. Furthermore, 3D imaging of visibly opaque silicon objects was achieved with a depth precision of 1.7 μm. The demonstrated results indicate the high potential of the proposed method for in-line or in-process non-destructive inspection of soft materials.     

Stable and Metastable Phase Relationships in the System ZrO2–ErO1.5

Stable and metastable phase relationships in the system ZrO₂–ErO_1.5 were investigated using homogeneous samples prepared by rapid quenching of melts and by arc melting. The rapidly quenched samples were annealed in air for 48 h at 1690°C or for 8 months at 1315°C. Two tetragonal phases ( t - and t '-phases) were observed after quenching samples heated at 1690°C to a room temperature, whereas one t -phase and cubic ( c -) phase were found in those treated at 1315°C. Since the t '-phase is obtained through a diffusionless transformation during cooling from a high-temperature c -phase, t - and c -phases can coexist at high temperature. The t - and c -phases field spans from 4 to 10 mol% ErO_1.5 at 1690°C and from 3 to 15 mol% ErO_1.5 at 1315°C. The equilibrium temperature T ^t-m ₀ between the t - and monoclinic ( m -) phases estimated from A_s and M_s temperatures decreased with increasing ErO_1.5 contents.