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331.
Ali Alipour Najmi Elchin Jafariyeh-Yazdi Mojgan Hadian Jos Hermans Prof. Rainer Bischoff Prof. Jun Yue Prof. Alexander Dömling Prof. Arne Wittstock Dr. Hjalmar P. Permentier 《ChemMedChem》2022,17(11):e202200040
A novel method for the selective catalytic N-dealkylation of drug molecules on a nanoporous gold (NPG) catalyst producing valuable N-dealkylated metabolites and intermediates is described. Drug metabolites are important chemical entities at every stage of drug discovery and development, from exploratory discovery to clinical development, providing the safety profiles and the ADME (adsorption, distribution, metabolism, and elimination) of new drug candidates. Synthesis was carried out in aqueous solution at 80 °C using air (oxygen source) as oxidant, in single step with good isolated yields. Different examples examined in this study showed that aerobic catalytic N-dealkylation of drug molecules on NPG has a broad scope supporting N-deethylation, N-deisopropylation and N-demethylation, converting either 3° amines to 2° amines, or 2° amines to 1° amines. 相似文献
332.
Aziz Maleki Mohammad Seyedhamzeh Meng Yuan Tarun Agarwal Ibrahim Sharifi Abbas Mohammadi Pelin Kelicen-Uğur Mehrdad Hamidi Massoud Malaki Abdulaziz A. Al Kheraif Ziyong Cheng Jun Lin 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(12):2206253
Sonodynamic therapy (SDT) has considerably revolutionized the healthcare sector as a viable noninvasive therapeutic procedure. It employs a combination of low-intensity ultrasound and chemical entities, known as a sonosensitizer, to produce cytotoxic reactive oxygen species (ROS) for cancer and antimicrobial therapies. With nanotechnology, several unique nanoplatforms are introduced as a sonosensitizers, including, titanium-based nanomaterials, thanks to their high biocompatibility, catalytic efficiency, and customizable physicochemical features. Additionally, developing titanium-based sonosensitizers facilitates the integration of SDT with other treatment modalities (for example, chemotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, and immunotherapy), hence increasing overall therapeutic results. This review summarizes the most recent developments in cancer therapy and tissue engineering using titanium nanoplatforms mediated SDT. The synthesis strategies and biosafety aspects of Titanium-based nanoplatforms for SDT are also discussed. Finally, various challenges and prospects for its further development and potential clinical translation are highlighted. 相似文献
333.