A quantitative multimodal discourse analysis of teaching and learning in a web-conferencing environment – The efficacy of student-centred learning designs

This paper presents a quantitative approach to multimodal discourse analysis for analyzing online collaborative learning. The coding framework draws together the fields of systemic functional linguistics and Activity Theory to analyze interactions between collaborative-, content- and technology-related discourse. The approach is used to examine how the task subject matter, the activity design, and the choice of interface affected interaction and collaboration for a computing course conducted in a web-conferencing environment. The analysis revealed the critical impact of activity design on the amount and type of discourse that transpired. Student-centred designs resulted in over six times more student discourse as compared to teacher-centred designs and created a learning environment where students took greater ownership over the tasks and contributed more to the content-based discussion. The paper also incorporates a rationale for the approach to coding and a reflection on its efficacy for discourse analysis in technology-based learning environments.     

State-Space Synthesis of Virtual Auditory Space

Binaural displays for immersive listening must model realistic acoustic environments, multiple sound sources, and accommodate source and head motion. Many displays accomplish this by convolving collections of spatially distributed point sources with head-related transfer functions (HRTFs). The computational load of such a system scales linearly with the number of HRTFs modeled by the display. Realistic scenes often require a large number of HRTFs, and this framework is computationally burdensome. We propose a method that significantly eases this load by formulating the HRTF filter array as a state-space system. Three state-space architectures are explored. The performance of the most general architecture is found to suffer due to the interaural time delay (ITD). This problem may be circumvented with two alternative architectures, although the ideal choice depends on the specific display application. For each architecture, two order-reduction techniques are explored. Both techniques are based on the Hankel operator; one is ad hoc and simple to implement whereas the other is optimal in the Hankel norm. The two methods yield similar auditory performance, although the optimal method may be desirable for HRTF approximation.     

The Informational Turn in Philosophy1

This paper traces the application of information theory to philosophical problems of mind and meaning from the earliest days of the creation of the mathematical theory of communication. The use of information theory to understand purposive behavior, learning, pattern recognition, and more marked the beginning of the naturalization of mind and meaning. From the inception of information theory, Wiener, Turing, and others began trying to show how to make a mind from informational and computational materials. Over the last 50 years, many philosophers saw different aspects of the naturalization of the mind, though few saw at once all of the pieces of the puzzle that we now know. Starting with Norbert Wiener himself, philosophers and information theorists used concepts from information theory to understand cognition. This paper provides a window on the historical sequence of contributions made to the overall project of naturalizing the mind by philosophers from Shannon, Wiener, and MacKay, to Dennett, Sayre, Dretske, Fodor, and Perry, among others. At some time between 1928 and 1948, American engineers and mathematicians began to talk about `Theory of Information' and `Information Theory,' understanding by these terms approximately and vaguely a theory for which Hartley's `amount of information' is a basic concept. I have been unable to find out when and by whom these names were first used. Hartley himself does not use them nor does he employ the term `Theory of Transmission of Information,' from which the two other shorter terms presumably were derived. It seems that Norbert Wiener and Claude Shannon were using them in the Mid-Forties.(Yehoshua Bar-Hillel, 1955)     

Clinically Applicable Assessment of Tisagenlecleucel CAR T Cell Treatment by Digital Droplet PCR for Copy Number Variant Assessment

Chimeric antigen receptor (CAR) T cell therapy is an innovative immunotherapy for treating cancers in both children and adults with proven utility in numerous clinical trials. Significantly, some CAR T cell therapies have now been approved by relevant national regulatory bodies across numerous countries for clinical therapeutic use outside of clinical trials. One such recently licensed product is tisagenlecleucel, a CAR T therapy approved for the treatment of B-cell acute lymphoblastic leukemia (B-ALL) using autologous T cells from the patient. The genetically engineered T cells target a protein called CD19, common to B cells, through a CAR incorporating a 4-1BB costimulatory domain to improve response. Since tisagenlecleucel is now a standard of care treatment for B-ALL, it is clinically essential to be able to accurately monitor these CAR T cells in patients. Assessment of the copy number variant (CNV) of the CAR T cell products allows this within a clinically acceptable timeframe for optimal patient benefit. However, no standardized method with high reproducibility and efficiency has been described within a routine clinical laboratory setting. Here, we demonstrated a novel digital droplet PCR (ddPCR)-based methodology for the study of CNV (ddPCR-CNV) in 4-1BB CD19-specific CAR T cells with universal applicability across clinical diagnostic laboratories.     

Engineering-Based Decisions in Construction

This paper uses four case studies to emphasize the fact that field engineering decisions cannot be made without a full understanding of all the technical problems involved. Two of the studies are taken from conventional design-bid-build projects and two are taken from design-build projects in which the ability to strongly influence design in the interest of construction efficiency places a new and increased emphasis on construction and field engineering skills. The cases also show that field engineering decisions frequently address new and unexpected realities, changed conditions, and transient loads, and thus they require high levels of understanding, technical analysis, and creative thought. We emphasize the need for universities and construction engineering programs to develop graduates who are capable of integrating design and construction considerations throughout the project delivery process. We also urge programs to continue to focus strongly on field engineering as the foundation for success in an increasingly complex and technically driven construction industry.