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101.
Silvia Gazzin Matteo Dal Ben Michele Montrone Sri Jayanti Andrea Lorenzon Alessandra Bramante Cristina Bottin Rita Moretti Claudio Tiribelli 《International journal of molecular sciences》2021,22(1)
Bilirubin toxicity to the central nervous system (CNS) is responsible for severe and permanent neurologic damage, resulting in hearing loss, cognitive, and movement impairment. Timely and effective management of severe neonatal hyperbilirubinemia by phototherapy or exchange transfusion is crucial for avoiding permanent neurological consequences, but these therapies are not always possible, particularly in low-income countries. To explore alternative options, we investigated a pharmaceutical approach focused on protecting the CNS from pigment toxicity, independently from serum bilirubin level. To this goal, we tested the ability of curcumin, a nutraceutical already used with relevant results in animal models as well as in clinics in other diseases, in the Gunn rat, the spontaneous model of neonatal hyperbilirubinemia. Curcumin treatment fully abolished the landmark cerebellar hypoplasia of Gunn rat, restoring the histological features, and reverting the behavioral abnormalities present in the hyperbilirubinemic rat. The protection was mediated by a multi-target action on the main bilirubin-induced pathological mechanism ongoing CNS damage (inflammation, redox imbalance, and glutamate neurotoxicity). If confirmed by independent studies, the result suggests the potential of curcumin as an alternative/complementary approach to bilirubin-induced brain damage in the clinical scenario. 相似文献
102.
Matteo Leoni Rosa Di Maggio Stefano Polizzi Paolo Scardi 《Journal of the American Ceramic Society》2004,87(6):1133-1140
The microstructural evolution of nanocrystalline ceria produced by sol–gel has been analyzed as a function of the calcination temperature employing a novel nondestructive method based on the modeling of the whole X-ray diffraction pattern. The results have been thoroughly verified by transmission electron microscopy. A variation both in the average size and in the distribution of the crystalline domains is evidenced. In addition, information concerning lattice defects can be inferred on a larger scale than that normally accessible by microscopy techniques. 相似文献
103.
Paola Maroni Paola Bendinelli Daniele Morelli Lorenzo Drago Alessandro Luzzati Giuseppe Perrucchini Chiara Bonini Emanuela Matteucci Maria Alfonsina Desiderio 《International journal of molecular sciences》2015,16(12):28108-28122
In order to become established in the skeleton, metastatic cells disseminating from the breast carcinoma need to acquire organ-specific traits. There are no effective predictors for who will develop bone metastasis to guide long-term predictive therapy. Our purpose was to individuate events critical for bone colonization to make a molecular classification of breast carcinoma useful for bone-metastasis outcome. In dysplasia adjacent to carcinoma and in pair-matched specimens of bone metastasis we examined SPARC expression and localization as well as Endothelin 1/ETAR signals by immunohistochemistry, and the evaluation of plasma levels of SPARC by ELISA was also performed. In patients with breast carcinoma metastasizing to bone, SPARC and Endothelin 1/ETAR axis were highly expressed from dysplasia until bone metastasis, but the SPARC plasma level was as low as that of normal women, in contrast to patients that never develop bone metastasis, suggesting that circulating SPARC was counter adhesive. Altogether, the early identification of SPARC/Endothelin 1/ETAR in dysplastic lesions would be important to devise therapies preventing metastasis engraftment, since often carcinoma cells spread to distant organs at the time or even before patients present with cancer. 相似文献
104.
Sorichetti P.A. Matteo C.L. Lambri O.A. Manguzzi G.C. Salvatierra L.M. Herrero O. 《Dielectrics and Electrical Insulation, IEEE Transactions on》2007,14(5):1170-1182
This work presents a study of the structural changes in aged EPDM (ethylene-propylene-diene monomer) from outdoor high voltage transmission lines. Samples were taken from failed and non-failed insulators after up to ten years in service on a 33 kV line. Infrared absorption, hydrophobicity index, dynamical mechanical analysis (DMA) and dielectric relaxation (DR) were employed as experimental techniques. The same experimental techniques were also applied to new samples of EPDM that were subjected to high electric fields (up to 14 kV/mm) for several hours. Results from DMA and DR techniques are in good agreement and, together with previous results from neutron irradiation techniques, suggest that the experimental data obtained from outdoor-aged and laboratory tested samples may be explained by a decrease in the degree of crystallinity due to the interaction between electrical and mechanical effects in the dielectric. The proposed model is based on the disentanglement of the crystallites by forces originated in the interaction of the electric field with the polar groups located in the amorphous phase of the polymer matrix. An alternative explanation, based on a relaxation process appearing at the interfaces between the filler (ATH) and the polymer matrix conflicts with several experimental results presented in this work. 相似文献
105.
Fernando Fraternali Matteo Negri Michael Ortiz 《International Journal of Fracture》2010,166(1-2):3-11
Free discontinuity problems arising in the variational theory for fracture mechanics are considered. A Γ -convergence proof for an r-adaptive 3D finite element discretization is given in the case of a brittle material. The optimal displacement field, crack pattern and mesh geometry are obtained through a variational procedure that encompasses both mechanical and configurational forces. Possible extensions to cohesive fracture and quasi-static evolutions are discussed. 相似文献
106.
Rahul Sasidharan Pillai Matteo Frasnelli Vincenzo M. Sglavo 《Ceramics International》2018,44(2):1328-1333
The present work focuses on the fabrication of βTCP (β-tricalcium phosphate) and HA/βTCP (hydroxyapatite/β-tricalcium phosphate) composite coatings by plasma spraying. The starting powders were produced via solid-state method using 2 wt% MgO to stabilize βTCP phase. The synthesized powders were preliminarily granulated to be used by the plasma spray process. Coatings obtained on titanium substrates are uniform and well adherent but due to the high temperature and cooling rate typical for plasma spraying process, βTCP phase is almost totally transformed into the α allotrope. Thermal treatment at 800 °C allows the reconversion of the phase αTCP→ βTCP. It is therefore possible to produce coatings with tuneable dissolution properties by selecting the proper initial powder mixture and the specific thermal treatment. 相似文献
107.
Jeffrey E. Marchese Matteo Cirillo Niels Grøch-Jensen 《Open Systems & Information Dynamics》2007,14(2):189-196
We present evidence for a close analogy between the nonlinear behaviour of a pulsed microwave-driven Josephson junction at
low temperature and the experimentally observed behaviour of Josephson systems operated below the quantum transition temperature
under similar conditions. We specifically address observations of Ramsey-type fringe oscillations, which can be understood
in classical nonlinear dynamics as results of slow transient oscillations in a pulsed microwave environment. Simulations are
conducted to mimic experimental measurements by recording the statistics of microwave-induced escape events from the anharmonic
potential well of a zero-voltage state. Observations consistent with experimentally obtained Ramsey-type oscillations are
found in the classical model.
An erratum to this article can be found at 相似文献
108.
Virtual Reality - The intersection between sound and music computing and Virtual Reality (VR) has grown significantly over the past decades, amounting to an established area of research today.... 相似文献
109.
110.
The aim of this paper is to deal with the problem of fault tolerant control in the framework of discrete event systems modeled as automata. A fault tolerant controller is a controller able to satisfy control specifications both in nominal operation and after the occurrence of a fault. This task is solved by means of a parameterized controller that is suitably updated on the basis of the information provided by online diagnostics: the supervisor actively reacts to the detection of a malfunctioning component in order to eventually meet degraded control specifications. Starting from an appropriate model of the system, we recall the notion of safe diagnosability as a necessary step in order to achieve fault tolerant control. We then introduce two new notions: (i) “safe controllability”, which represents the capability, after the occurrence of a fault, of steering the system away from forbidden zones and (ii) “active fault tolerant system”, which is the property of safely continuing operation after faults. Finally, we show how the problem can be solved using a general control architecture based on the use of special kind of diagnoser, called “diagnosing controller”, which is used to safely detect faults and to switch between the nominal control policy and a bank of reconfigured control policies. A simple example is used to illustrate the new notions and the control architecture introduced in the paper. 相似文献