Energy and environmental performance of a heat pump in different power grid scenarios

Electric-driven heat pumps are one of the most encouraging systems that could support the raising of renewables contribution in civil sector energy consumption, especially with reference to the Countries with a high contribution of renewable energy sources in electricity generation mix. However, the evaluation of the effective energy and environmental performance of an electric heat pump meeting the space heating and cooling requests of a building has to consider several factors that affect the results. Among them great attention should be given to the variability of weather conditions in which the system operates, the changeability of the efficiency and environmental indicators of power grid. The analysis becomes more complex if the variation of these parameters is considered in terms of time and geographic location but it leads to the actual evaluation of the energy conversion system performance that is neglected by European Regulations. This paper presents an energy and environmental analysis of an electric-driven air-source heat pump providing the space heating and cooling needs of the same building located in two different geographical locations by means of a dynamic simulation performed in TRNSYS 17. The analysis is carried out considering the average and time-dependent values of the carbon dioxide emission factors for electricity and the power grid efficiency indicators evaluated by means of the real electricity generation data. In addition, the paper proposes the evaluation of the average and hourly energy and environmental parameters referred only to the electricity market zones in which the buildings are located. These indices are considered in the analysis too. The results have highlighted that the assessment based on average and high-resolution parameters, as well the evaluation based on indicators referred to electricity market zones only, could return very different outcomes leading to a significant overestimation or underestimation of the energy and environmental performance of the system based on the electric-driven heat pump. Finally, a further analysis has been carried out to determine how the results can vary considering the average value of the electric efficiency indicator suggested by Italian Regulations and that of other European Countries.     

Stability and Cell Permeability of Sulfonyl Fluorides in the Design of Lys-Covalent Antagonists of Protein-Protein Interactions

Recently we reported on aryl-fluorosulfates as possible stable and effective electrophiles for the design of lysine covalent, cell permeable antagonists of protein–protein interactions (PPIs). Here we revisit the use of aryl-sulfonyl fluorides as Lys-targeting moieties, incorporating these electrophiles in XIAP (X-linked inhibitor of apoptosis protein) targeting agents. We evaluated stability in buffer and reactivity with Lys311 of XIAP of various aryl-sulfonyl fluorides using biochemical and biophysical approaches, including displacement assays, mass spectrometry, SDS gel electrophoresis, and denaturation thermal shift measurements. To assess whether these modified electrophilic “warheads” can also react with Tyr, we repeated these evaluations with a Lys311Tyr XIAP mutant. Using a direct cellular assay, we could demonstrate that selected agents are cell permeable and interact covalently with their intended target in cell. These results suggest that certain substituted aryl-sulfonyl fluorides can be useful Lys- or Tyr-targeting electrophiles for the design of covalent pharmacological tools or even future therapeutics targeting protein–protein interactions.     

Infrared Comb Spectroscopy of Buffer-Gas-Cooled Molecules: Toward Absolute Frequency Metrology of Cold Acetylene

We review the recent developments in precision ro-vibrational spectroscopy of buffer-gas-cooled neutral molecules, obtained using infrared frequency combs either as direct probe sources or as ultra-accurate optical rulers. In particular, we show how coherent broadband spectroscopy of complex molecules especially benefits from drastic simplification of the spectra brought about by cooling of internal temperatures. Moreover, cooling the translational motion allows longer light-molecule interaction times and hence reduced transit-time broadening effects, crucial for high-precision spectroscopy on simple molecules. In this respect, we report on the progress of absolute frequency metrology experiments with buffer-gas-cooled molecules, focusing on the advanced technologies that led to record measurements with acetylene. Finally, we briefly discuss the prospects for further improving the ultimate accuracy of the spectroscopic frequency measurement.     

Virtual dives into the underwater archaeological treasures of South Italy

The paper presents a virtual diving system based on a virtual reality (VR) application for the exploitation of the Underwater Cultural Heritage. The virtual diving experience has been designed to entertain users, but its added pedagogical value is explicitly emphasized too. In fact, the ludic activities, consisting in the simulation of a real diving session from the point of view of a scuba diver, are following a storyline described by a virtual diving companion who guides users during the exploration of the underwater archaeological site. The virtual diving system provides general and historical-cultural contents, but also information about the flora and fauna of the specific submerged site to the users. The results collected through user studies demonstrate that the proposed VR system is able to provide a playful learning experience, with a high emotional impact, and it has been well appreciated by a large variety of audiences, even by younger and inexperienced users.     

Differential Expression of Sphingolipid Metabolizing Enzymes in Spontaneously Hypertensive Rats: A Possible Substrate for Susceptibility to Brain and Kidney Damage

Alterations in the metabolism of sphingolipids, a class of biologically active molecules in cell membranes with direct effect on vascular homeostasis, are increasingly recognized as important determinant in different vascular disorders. However, it is not clear whether sphingolipids are implicated in the pathogenesis of hypertension-related cerebrovascular and renal damage. In this study, we evaluated the existence of possible abnormalities related to the sphingolipid metabolism in the brain and kidneys of two well validated spontaneously hypertensive rat strains, the stroke-prone (SHRSP) and the stroke-resistant (SHRSR) models, as compared to the normotensive Wistar Kyoto (WKY) rat strain. Our results showed a global alteration in the metabolism of sphingolipids in both cerebral and renal tissues of both hypertensive strains as compared to the normotensive rat. However, few defects, such as reduced expression of enzymes involved in the metabolism/catabolism of sphingosine-1-phosphate and in the de novo biosynthetic pathways, were exclusively detected in the SHRSP. Although further studies are necessary to fully understand the significance of these findings, they suggest that defects in specific lipid molecules and/or their related metabolic pathways may likely contribute to the pathogenesis of hypertensive target organ damage and may eventually serve as future therapeutic targets to reduce the vascular consequences of hypertension.     

Automatic Design of Cable-Tensioned Glass Shells

We propose an optimization algorithm for the design of post-tensioned architectural shell structures, composed of triangular glass panels, in which glass has a load-bearing function. Due to its brittle nature, glass can fail when it is subject to tensile forces. Hence, we enrich the structure with a cable net, which is specifically designed to post-tension the shell, relieving the underlying glass structure from tension. We automatically derive an optimized cable layout, together with the appropriate pre-load of each cable. The method is driven by a physically based static analysis of the shell subject to its service load. We assess our approach by applying non-linear finite element analysis to several real-scale application scenarios. Such a method of cable tensioning produces glass shells that are optimized from the material usage viewpoint since they exploit the high compression strength of glass. As a result, they are lightweight and robust. Both aesthetic and static qualities are improved with respect to grid shell competitors.     

The Role of Extracellular Vesicles (EVs) in the Epigenetic Regulation of Bone Metabolism and Osteoporosis

Extracellular vesicles (EVs) are complex phospholipidic structures actively released by cells. EVs are recognized as powerful means of intercellular communication since they contain many signaling molecules (including lipids, proteins, and nucleic acids). In parallel, changes in epigenetic processes can lead to changes in gene function and finally lead to disease onset and progression. Recent breakthroughs have revealed the complex roles of non-coding RNAs (microRNAs (miRNAs) and long non-coding RNAs (lncRNAs)) in epigenetic regulation. Moreover, a substantial body of evidence demonstrates that non-coding RNAs can be shuttled among the cells and tissues via EVs, allowing non-coding RNAs to reach distant cells and exert systemic effects. Resident bone cells, including osteoclasts, osteoblasts, osteocytes, and endothelial cells, are tightly regulated by non-coding RNAs, and many of them can be exported from the cells to neighboring ones through EVs, triggering pathological conditions. For these reasons, researchers have also started to exploit EVs as a theranostic tool to address osteoporosis. In this review, we summarize some recent findings regarding the EVs’ involvement in the fine regulation of non-coding RNAs in the context of bone metabolism and osteoporosis.     

On the ability of chromatographic mass balance to predict solute diffusivity in drug delivery systems

The ability to predict the drug diffusion coefficient within hydrogel-based drug delivery devices has a pivotal role in the design of these materials. In the last years, many mathematical models have been developed, but they often rely on fitted parameters with a consequent limitation in terms of prediction. Indeed, they are mainly centered on the pure Fickian diffusion together with degradation and swelling contributions. However, especially with a drug concentration typical of pharmacological treatments, several other mechanisms such as drug–polymer and drug–drug interactions cannot be neglected. In this work, we checked the ability of a simple mathematical model to estimate diffusion coefficients of drugs loaded within hydrogel considered as a chromatographic stationary phase. Mathematical modeling satisfactorily matched with different sets of literature data proving that our assumptions are able to describe the key phenomena governing the device's behavior.     

Project leaders in transition: Manifestations of cognitive and emotional capacity

This research contributes to a dearth of research into leadership that focuses explicitly on senior leaders of complex projects. It identifies five transitions that were seen as essential as these project leaders developed their capacity to lead, including transitions towards: orchestrating dialogue between the right people, at the right time, about the right issues; guiding collaborative meaning-making to align key stakeholders; drawing on practical wisdom and judgment to progress complex project challenges; developing a range of power sources, and sensing a pathway through power dynamics; and negotiating project success for key stakeholders based on a broad concept of value. Instead of merely seeing this as the development of new skills, we argue that these transitions are manifestations of an increase of a more deeply rooted capacity to deal with cognitive and emotional complexity. This difference matters as learning a new skill requires a very different approach to stepping up an order of constructive development. A constructive developmental perspective appears particularly helpful for understanding how senior project leaders of complex projects learn to deal with the relentless onslaught of challenges that their projects can bring.     

Multiple-high altitude platforms aided system architecture for achieving maximum last mile capacity in satellite communication

Telecommunication Systems - Satellite communication provides services to users over wide area. However, the propagation delay and the link budget associated with the long path make the...