Potential Pro-Inflammatory Effect of Vitamin E Analogs through Mitigation of Tetrahydrocannabinol (THC) Binding to the Cannabinoid 2 Receptor

Vitamin E acetate, which is used as a diluent of tetrahydrocannabinol (THC), has been reported as the primary causative agent of e-cigarette, or vaping, product use-associated lung injury (EVALI). Here, we employ in vitro assays, docking, and molecular dynamics (MD) computer simulations to investigate the interaction of vitamin E with the membrane-bound cannabinoid 2 receptor (CB2R), and its role in modulating the binding affinity of THC to CB2R. From the MD simulations, we determined that vitamin E interacts with both CB2R and membrane phospholipids. Notably, the synchronized effect of these interactions likely facilitates vitamin E acting as a lipid modulator for the cannabinoid system. Furthermore, MD simulation and trajectory analysis show that when THC binds to CB2R in the presence of vitamin E, the binding cavity widens, facilitating the entry of water molecules into it, leading to a reduced interaction of THC with CB2R. Additionally, the interaction between THC and vitamin E in solution is stabilized by several H bonds, which can directly limit the interaction of free THCs with CB2R. Overall, both the MD simulations and the in vitro dissociation assay results indicate that THC binding to CB2R is reduced in the presence of vitamin E. Our study discusses the role of vitamin E in limiting the effect of THCs and its implications on the reported pathology of EVALI.     

Radio resource management for LTE-A relay-enhanced cells with spatial reuse and max–min fairness

One of the major issues in LTE-Advanced (LTE-A) systems is the poor capacity at the cell edge. This is mainly due to the interference experienced by the users as a result of the aggressive frequency reuse usually implemented. Relaying offers an attractive solution for this problem by offering better links than those with the eNodeB (eNB) for the terminals suffering from high path loss or high interference. However, adding relays complicates the resource allocation problem at the eNB and therefore the need for more efficient schemes arises. This is also aggravated by the reuse of resource blocks (RBs) by the relays to fully exploit the scarce spectrum, which, in turn, leads to intra-cell interference. In this paper, we study the joint power and resource allocation problem in LTE-A relay-enhanced cells that exploit spatial reuse. To guarantee fairness among users, a max–min fair optimization objective is used. This complex problem is solved using coordinate ascent and the difference of two convex functions (DC) programming techniques and the proposed scheme indeed converges to a local-optimum quickly. This is shown to be a satisfactory solution according to the simulation results that indicate an almost sevenfold increase in the 10th percentile capacity when compared to previously proposed solutions.     

Simulation of driver fatigue monitoring via blink rate detection,using 65 nm CMOS technology

This paper proposes a system to detect and measure blink rate to determine fatigue levels. The method involved analysing specific frames to determine that a blink occurred, and then monitoring the time between successive blinks. The program was simulated in python using a Raspberry Pi Zero and a standard USB camera. For the blink rate detection block, a gate level schematic was implemented in Cadence software using 65 nm CMOS technology. The design was based around an asynchronous 6-bit based edge counter which was designed using D-flip-flops. The simulation calculated the average blink rate and compared this to the most recent blink rate. The outcome would determine if an alarm signal should be sent to the alarm. The system consumed 130 μA from a 1.2 V power supply.     

2D and 3D numerical simulation of the wind-rotor/nacelle interaction in an atmospheric boundary layer

Two-dimensional axisymmetric and three-dimensional steady turbulent flow computations around two horizontal-axis wind turbines (Nordex N80 and Jeumont J48) are carried out to investigate the wind-rotor/nacelle interaction and quantify its effects on the wind speed at the nacelle anemometry. The actuator disk concept has been used to model the action of the blades. For both turbines, the geometry of the nacelle was reproduced as faithfully as possible. The terrain was represented by an appropriate law of the wall to account for roughness with particular attention paid to the boundary conditions in order to reproduce the neutral atmospheric boundary layer. The calculated velocity field in the vicinity of the nacelle exhibits good agreement with available experimental data. The results also show that for a complex nacelle geometry, like that of the N80, a three-dimensional calculation is necessary to obtain a good prediction of the velocity field in the near wake. The hub height effect is evaluated for the J48 by raising the nacelle from a height of 36 to 60 m. No significant impact is noted on the ratio nacelle wind speed/freestream wind speed.     

An efficient extraction and clean‐up procedure for pesticide determination in olive oil

This work reports a simple, rapid, and effective extraction method based on liquid–liquid extraction (LLE) followed by matrix solid‐phase dispersion‐sonication for detection, identification and quantification of multiclass pesticides in virgin olive oil using liquid chromatography mass spectrometry (LC‐QTOF‐MS). LLE to extract pesticide residues in virgin olive oil was performed in order to study the centrifugation efficiency to obtain high recovery yield and low co‐extract fat residue in the final extract. Different suitable parameters of MSPD procedure were evaluated, such as nature of dispersing phase, clean‐up adsorbent, and volume of eluting solvent (acetonitrile) in different extraction conditions, with or without sonication. The best results were obtained using 5 g of virgin olive oil, 2 g of PSA as dispersant sorbent, 2 g of Florisil/GCB (70:30 w/w) as clean‐up sorbent, and 15 mL of acetonitrile as eluting solvent under conditions of 15 min ultrasonic bath at RT. Method validation was performed in order to study sensitivity, linearity, precision, and accuracy. Average recoveries ranged between 73.7 and 104.2% with relative SDs 5.3–13.4% at three concentration levels (25, 50, and 100 µg/kg). Detection and quantification limits ranged from 1.5 to 5 µg/kg and 3 to 9 µg/kg, respectively.     

Modeling, design and thermal performance of a BIPV/T system thermally coupled with a ventilated concrete slab in a low energy solar house: Part 2, ventilated concrete slab

This paper is the second of two papers that describe the modeling and design of a building-integrated photovoltaic-thermal (BIPV/T) system thermally coupled with a ventilated concrete slab (VCS) adopted in a prefabricated, two-storey detached, low energy solar house and their performance assessment based on monitored data. The VCS concept is based on an integrated thermal-structural design with active storage of solar thermal energy while serving as a structural component - the basement floor slab (∼33 m²). This paper describes the numerical modeling, design, and thermal performance assessment of the VCS. The thermal performance of the VCS during the commissioning of the unoccupied house is presented. Analysis of the monitored data shows that the VCS can store 9-12 kWh of heat from the total thermal energy collected by the BIPV/T system, on a typical clear sunny day with an outdoor temperature of about 0 °C. It can also accumulate thermal energy during a series of clear sunny days without overheating the slab surface or the living space. This research shows that coupling the VCS with the BIPV/T system is a viable method to enhance the utilization of collected solar thermal energy. A method is presented for creating a simplified three-dimensional, control volume finite difference, explicit thermal model of the VCS. The model is created and validated using monitored data. The modeling method is suitable for detailed parametric study of the thermal behavior of the VCS without excessive computational effort.     

Experimental study on the compressive resistance of stress-relieved solid round steel members

The Canadian Standard for Antenna Towers and Antenna Supporting Structures, CSA-S37-01, specifies expressions for the compressive resistance of solid rounds based on the Structural Stability Research Council (SSRC) Column Curves for non-solid-round members and the results from experimental investigations on the compressive resistance of solid rounds carried out back to 1965. Similar Standard in USA (TIA/EIA-222-G.0) specifies design criteria for such members as derived from the superseded AISC-LRFD-94 Standard, which is independent of the shape of the member cross-section. The European Standard, Eurocode 3, provides column curves for the compressive resistance of various structural steel members, and assumes the applicability of one of them to solid rounds. As such, it is necessary to conduct an experimental study on solid round stress-relieved steel members to refine the available design equations for such members. This paper provides a summary of the literature review on solid rounds as well as a recent test program conducted on stress-relieved steel solid rounds. Correlation between the results from these tests and the current practice for the design of solid rounds is investigated. The paper concludes with a proposed compressive resistance equation for economical design of such members.     

Estimated daily intake of pesticide residues exposure by vegetables grown in greenhouses in Al-Qassim region,Saudi Arabia

Residues of 23 pesticides (13 insecticides, 3 fungicides, 3 herbicides, 2 acaricides, 1 rodenticide and 1 nematicide) in 160 different vegetable samples cultivated under greenhouse conditions and collected from 4 major supermarkets located in Al-Qassim region, Saudi Arabia were monitored. A multiresidue method was carried out by gas chromatography with mass spectrometry (GC–MS). Residues were found in 89 samples. Fifty four samples were found above the maximum residue levels (MRLs). The most frequently found pesticides were carbaryl followed by biphenyl and then carbofuran. MRL values exceeded most often in cabbage (11 samples) followed by squash, green pepper and carrot (7 samples each) followed by cucumber and lettuce (6 samples each), egg-plant (5 samples) and then tomato (4 samples). Also, cabbage showed the highest contamination rates (16 samples), followed by carrot, cucumber and green pepper (12 samples each), squash (11 samples), lettuce and tomato (9 samples each) and egg-plant (8 samples). The highest concentrations were determined in lettuce followed by squash, cabbage and carrot. Al-Qassim region population’s average daily intake (EDI) has been estimated between 2 × 10^?5 and 0.597 μg/kg body weight/day and the hazard index (EDI/acceptable daily intake (ADI)) less than the unity for the tested compounds. The data illustrated that the intakes are much lower than the ADIs and the exposure level to whole pesticides was below the level to produce health risk. The data indicated also the need for regular monitoring programs for pesticide residues in vegetables cultivated under greenhouse conditions, at the national level, to protect consumers’ health.     

Multiconsistency and Robustness with Global Constraints

We propose a natural generalization of arc-consistency, which we call multiconsistency: a value v in the domain of a variable x is k-multiconsistent with respect to a constraint C if there are at least k solutions to C in which x is assigned the value v. We present algorithms that determine which variable-value pairs are k-multiconsistent with respect to several well known global constraints. In addition, we show that finding super solutions is sometimes strictly harder than finding arbitrary solutions for these constraints and suggest multiconsistency as an alternative way to search for robust solutions.Supported by the Danish Research Agency (grant # 272-05-0081).Basic Research in Computer Science, funded by the Danish National Research Foundation.     

Effect of Fiber-Reinforced Polymer Wraps on Corrosion Activity and Concrete Cracking in Chloride-Contaminated Concrete Cylinders

This paper presents the results of an experimental study designed to investigate the effect of fiber-reinforced polymer (FRP) wraps on corrosion activity and concrete cracking in chloride-contaminated concrete cylinders. Thirty-five concrete cylinders, each having 102?mm diameter and 204?mm height, concentrically reinforced with one steel reinforcing bar, were subjected to accelerated corrosion exposure for 80?days. Test parameters included level of applied potential, presence of FRP wraps, and bar diameter. The corresponding current and concrete expansion were continuously monitored throughout the corrosion exposure. At the end of the test, the steel bars were extracted, cleaned of rust, and weighed to determine the actual steel mass loss. The results showed that, for the same applied fixed potential, FRP wraps effectively reduced the corresponding current, the concrete expansion, and the steel mass loss. For the same applied potential, the current density increased as the bar diameter decreased. For the same corrosion depth, the circumferential expansion of the cylinder caused by corrosion decreased as the concrete cover-to-bar diameter ratio (c/d) increased.