Variability in the interpretation of thorax radiography in a primary care medical community and its reference radiologists

OBJECTIVE: To know the variability in the interpretation (normal/pathological) of posteroanterior view chest radiograph and the associated factors between a medical primary care community and a Gold Standard (GS) from 3 reference radiologists. DESIGN: Crossover study. SETTING: Primary care. Teaching health centers of Elche. METHODS: Interobserver percentage agreement (IPA) and Kappa statistic (K) were used to analyse the interobserver agreement (IA) between the GS and every of the participants in interpretation of 100 radiographs. Intraobserver variability was assessed with a second review. Using uni and multivariant analysis some possibly associated factors were studied. RESULTS: Overall IPA and K were 71.3% (CI 95%: 69.2-73.3) and 0.41 (CI 95%: 0.36-0.46) respectively. Time employed in radiographs reading and time passed after medicine studies finished were independently and significantly associated to higher and lower interobserver agreement results respectively, whereas recent professional experience, permanent job and age were not associated. Professional training is the variable that most explain the inter and intraobserver variability. CONCLUSIONS: Overall IA is acceptable. The IA showed by the participants trained under the MIR system is good but the IA achieved by the rest of participants is not acceptable. It is necessary a training which increase the clinical competence, as it does MIR training.     

浅谈系统稳定及励磁最优控制

最优励磁控制与一般比例励磁调节具有明显的优点,它可提高系统的微动稳定性和微动态稳定功率极限,且可改善系统的动态品质。文章简要推导了最优励磁控制采用二次型目标的控制式,论述了如何利用该控制式采用最优励磁控制提高系统稳定性。     

无线通信技术在沙漠油田安全生产中的应用

介绍无线通信技术在沙漠油田安全生产中的应用。     

模糊模式识别在轨道电路分路不良预警中的应用

针对站内25 Hz相敏轨道电路分路不良问题,通过系统分析,建立轨道电路预警模型,采用模糊模式识别方法实现轨道电路调整电压、现场温湿度以及故障次数的预警,并详细论述了轨道电路模糊模式识别模型的建立,同时给出了预警系统的实现方案;模拟实验及仿真结果表明,模糊模式识别在轨道电路分路不良预警中具有较高的准确性和应用价值,对解决轨道电路分路不良问题提供了有效的技术支持,为轨道电路日常维护和故障的及时发现处理创造了条件.     

基于蚁群优化的WSN能耗均衡链状路由协议

为了从路由技术的角度解决无线传感器网络的能耗问题,综合蚁群优化算法和PEGASIS协议的思想提出了ACO-PEGASIS路由协议;该协议采用蚁群优化算法构建通信链,解决了PEGASIS协议中由于贪婪算法的局部性产生的相邻节点间的长链问题;并在成链过程中综合考虑节点间距离、节点剩余能量等因子,以均衡全网的能量消耗;同时根据距离和能量因素选取链头节点并采用一定措施降低链头重选次数;仿真结果表明,与PEGASIS协议相比,该协议更加有效地均衡了全网的能量消耗,延长了网络的生存周期。     

A case of using the Semantic Interoperability Framework for custom orthopedic implants manufacturing

The efficiency and effectiveness of the daily practice in orthopedic surgery depend on the availability, interoperability and unique access to a wide set of information, related to the patient’s medical record and diagnosis, domain knowledge and available resources and staff. The most important of the tangible resources, needed for the therapeutic or preventive actions are orthopedic implants. In some cases, the implants may be highly complex and customized products, which need to be manufactured (assembled) on basis of the above information in a shortest possible timeframe. In this paper, the case of the custom orthopedic implants manufacturing is described from the perspective of the collaborative enterprising, with special consideration of the interoperability issues of the involved enterprise collaboration. It is shown how the previously developed Semantic Interoperability Framework can be used to improve the efficiency of the manufacturing and other relevant processes.     

基于Newsvendor型产品特性的FJSP问题研究

针对新时代环境下Newsvendor型产品销售期短、期末未出售产品价值递减的产品特点,生产链要求位于上游的供应商必须快速加工出所需的工件,否则将面临着线性递增的拖期惩罚。在面对基于Newsvendor型产品的柔性作业车间调度问题时,设计了一种加入禁忌搜索的混合遗传算法,扩大了解的搜索范围,避免了传统遗传算法容易陷于局部最优的缺陷。最后利用混合遗传算法对一个仿真案例进行求解。     

CRISPR/Cas9-Mediated Generation of Pathogen-Resistant Tomato against Tomato Yellow Leaf Curl Virus and Powdery Mildew

Tomato is one of the major vegetable crops consumed worldwide. Tomato yellow leaf curl virus (TYLCV) and fungal Oidium sp. are devastating pathogens causing yellow leaf curl disease and powdery mildew. Such viral and fungal pathogens reduce tomato crop yields and cause substantial economic losses every year. Several commercial tomato varieties include Ty-5 (SlPelo) and Mildew resistance locus o 1 (SlMlo1) locus that carries the susceptibility (S-gene) factors for TYLCV and powdery mildew, respectively. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) is a valuable genome editing tool to develop disease-resistant crop varieties. In this regard, targeting susceptibility factors encoded by the host plant genome instead of the viral genome is a promising approach to achieve pathogen resistance without the need for stable inheritance of CRISPR components. In this study, the CRISPR/Cas9 system was employed to target the SlPelo and SlMlo1 for trait introgression in elite tomato cultivar BN-86 to confer host-mediated immunity against pathogens. SlPelo-knockout lines were successfully generated, carrying the biallelic indel mutations. The pathogen resistance assays in SlPelo mutant lines confirmed the suppressed accumulation of TYLCV and restricted the spread to non-inoculated plant parts. Generated knockout lines for the SlMlo1 showed complete resistance to powdery mildew fungus. Overall, our results demonstrate the efficiency of the CRISPR/Cas9 system to introduce targeted mutagenesis for the rapid development of pathogen-resistant varieties in tomato.