Herd immunity to filarial infection is a function of vector biting rate

Despite the existence of an impressive body of work on human immune responses against filarial infections, the occurrence of a protective response to infection remains unclear. Here, we use a combined modelling and comparative data analysis framework to address this issue for human infections with the filarial parasite, Wuchereria bancrofti. By analogy with previous work, the analysis involves the comparison of observed field patterns of infection with epidemiological patterns predicted by a mathematical model of parasite immunity. Unlike most other human helminths, which are transmitted by ingestion or dermal penetration, exposure to infection with lymphatic filariasis can be measured explicitly in terms of vector mosquito biting rates, thereby also allowing, probably for the first time, examination of the suggested role of exposure in generating herd immunity to macroparasites. Observed field patterns in this study were derived from 19 different published studies, which gave parallel estimates of community exposure rates and the corresponding age--prevalence patterns of infection, while predictions of the epidemiological impact of herd immunity were obtained using a catalytic model framework. The results provide the first conclusive evidence to date that variations in the observed age--prevalence patterns of infection in filariasis can be effectively explained by the occurrence of an exposure-driven acquisition of herd immunity. We discuss this result in terms of implications for the new World Health Organization-led initiative for the global control of this parasitic disease.     

Ewald Hering und die Gegenfarbtheorie

Ewald Hering's color-opponent-theory is still considered one of the foundations of the visual sciences. Prior to Hering, Hermann v. Helmholtz introduced a theory of color appearance, which was based primarily on the physical aspects of the stimulus. In contrast to Helmholtz, Hering's theory strongly emphasized the subject's perception of color. As a consequence, Hering considered Helmholtz' theory inadequate. Contrary to some historical accounts, he did not object to Helmholtz's three-receptor explanation for color-mixture. Instead of Helmholtz' fundamental colors red, green, and blue, Hering suggested that the colors possess opponent character: blue-yellow; red-green; and, black-white. Helmholtz, on the other hand, refused to accept Hering's theory. Finally, a student with Helmholtz, Johannes v. Kries, developed the so-called “zone-theory”, which combines both, Young-Helmholtz's and Hering's theory at different stages of the visual information processing system.     

Safety of intrauterine contraceptive devices during MR imaging

OBJECTIVE: We report a case of candidiasis of the upper urinary tract that presented as acute renal failure associated with septic syndrome. The patient initially required hemodialysis. Right hydronephrosis and perirenal collection were observed on ultrasound examination. METHODS: A percutaneous nephrostomy was performed. Nephrostomy urine cytology and cultures were positive for Candida tropicalis. An anterograde pyelography showed a 'fungus ball' in the urinary tract. RESULTS: Therapy with oral fluconazole and percutaneous amphotericin B achieved excellent results. CONCLUSIONS: Candidiasic urinary infection of the upper urinary tract often produces obstructive uropathy requiring percutaneous nephrostomy, which can also be used to instill amphotericin B. Combination therapy with amphotericin B and fluconazole can achieve excellent results.     

Apparatus for steady-state kinetic measurements of the catalytic reduction of nitric oxide by ammonia on iron oxide

The reduction of nitric oxide with ammonia on an unsupported iron oxide catalyst has been studied in a continuous-flow recycle reactor using simulated flue gas. The responses of the employed reactor system to step and pulse inputs of tracer indicate that the system could be regarded as a continuous stirred tank reactor (CSTR). Preliminary tests were carried out to determine the effect of temperature and particle size on the measured reaction rates. Additional experiments were performed in order to study the influence of oxygen and water concentration on these rates. A gas chromatographic system has been developed to analyze the gas components NO, N₂O, NO₂, NH₃, H₂O, O₂, CO₂ and N₂. In addition, the concentrations of NO and NO₂ were measured with a nondisperse infrared (NDUV/NDIR) analyzer.     

The oxidative inducation test applied to medical PVC and other polymers

We have examined the applicability of this simple and effective test to polymer systems widely used in the medical industry. First, it was found that not every polymer examined exhibited a distinct onset of autocatalytic oxidation detectable by DSC. However, for cases where distinct onsets are found, powerful insights can be obtained. These included activation energy of the degradation, thermal oxidative shelf life prediction, and correlation, with product performances. Actual examples are presented to illustrate the utility of the test.     

Estimates of the dollar value of employee output in utility analyses: An empirical test of two theories.

Examined distributions of estimates of the dollar value of performance in studies employing the method of F. L. Schmidt et al (1979) for estimating the standard deviation of job performance (SDy) and found evidence that (1) the mean 50th percentile estimate is biased downward, (2) estimates of SDy appear to be a constant percentage of the 50th percentile estimate, and (3) estimates of SDy as a percentage of the 50th percentile value (SDp) are quite similar to empirical SDp values based on actual employee output. These findings suggest that the downward bias in the mean estimate of the 50th percentile causes the mean estimates of SDy to be similarly biased downward, but does not bias the estimates of SDp. Finally, an objective method for estimating the value of average employee output is described. The product of this value and the mean supervisory estimate of SDp yields an unbiased estimate of SDy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Origins and early years of the American Psychological Association, 1890–1906.

Many personal and professional concerns led G. Stanley Hall to found the American Psychological Association (APA) in 1892, and its subsequent development through its earliest years reflected the cultural and institutional milieu in which it emerged, much more than it did the intellectual and scientific issues that interested psychologists during that period. This essay traces APA's evolution through 1906 as an adaptation to the ecological setting in which it found itself and concludes that psychology's institutional relations with other sciences (and psychologist's professional relations with other scienctists) did much to shape the ecological niche in which APA established itself during its first decade and a half. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

FATIGUE LIFE ESTIMATION IN RESISTANCE SPOT WELDS: INITIATION AND EARLY GROWTH PHASE

Abstract— The main objective of this research is to develop a model of fatigue crack initiation and early crack growth in resistance spot welds that is specimen independent. This objective is achieved by examining the stress state around a resistance spot weld. A general expression for the structural stress around the weld is formulated that is dependent only on the loading immediately surrounding the weld. As such, it is specimen independent.
An additional objective is to explore the feasibility of applying this fatigue crack initiation model of life estimation using structural response data from finite element analysis (FEA). This numerical technique is often used for evaluating structural integrity of assemblies. Limited verification examples show that the structural stress range as calculated from FEA reaction load data is capable of describing fatigue crack initiation and early crack growth in cyclically loaded resistance spot welds.