全文获取类型
收费全文 | 1023篇 |
免费 | 58篇 |
专业分类
电工技术 | 16篇 |
化学工业 | 372篇 |
金属工艺 | 24篇 |
机械仪表 | 30篇 |
建筑科学 | 36篇 |
能源动力 | 27篇 |
轻工业 | 45篇 |
水利工程 | 1篇 |
石油天然气 | 3篇 |
武器工业 | 1篇 |
无线电 | 67篇 |
一般工业技术 | 172篇 |
冶金工业 | 73篇 |
原子能技术 | 8篇 |
自动化技术 | 206篇 |
出版年
2024年 | 3篇 |
2023年 | 11篇 |
2022年 | 71篇 |
2021年 | 81篇 |
2020年 | 31篇 |
2019年 | 36篇 |
2018年 | 42篇 |
2017年 | 32篇 |
2016年 | 34篇 |
2015年 | 46篇 |
2014年 | 50篇 |
2013年 | 73篇 |
2012年 | 65篇 |
2011年 | 64篇 |
2010年 | 61篇 |
2009年 | 56篇 |
2008年 | 33篇 |
2007年 | 45篇 |
2006年 | 37篇 |
2005年 | 19篇 |
2004年 | 21篇 |
2003年 | 15篇 |
2002年 | 17篇 |
2001年 | 3篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 8篇 |
1997年 | 12篇 |
1996年 | 8篇 |
1995年 | 7篇 |
1994年 | 8篇 |
1993年 | 10篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1981年 | 9篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1976年 | 4篇 |
1969年 | 1篇 |
1966年 | 1篇 |
1953年 | 1篇 |
排序方式: 共有1081条查询结果,搜索用时 0 毫秒
111.
Michal Košťál František Cvachovec Bohumil Ošmera Wolfgang Hansen Vlastimil Juříček 《Annals of Nuclear Energy》2010
The present paper deals with measured as well as calculated energy spectra of neutron and photon beams from the AKR-2 experimental reactor after having passed through Fe layers and Fe/H2O combined layers. The experiment results are compared with calculations presented in various nuclear data libraries, such as, ENDF/B VI.2., ENDF/B VII., BROND 3, JENDL 3.3 and JEFF 3.1. Two models were used to calculate the neutron transport. The first takes into account the atomic structure of the material, whereas the other neglects the effect of inter-atomic bonds assuming the atomic nucleus behaviour to follow the free gas model. 相似文献
112.
The pin power density distribution in reactor is an important quantity, necessary for the adequate assessment of fuel conditions and of core structures and pressure vessel radiation embrittlement as well.The paper shows the detailed comparison of calculated and experimentally determined pin by pin power distribution. To verify the reliability of measured data used for comparison with calculated data, the symmetrically located pins were measured. The calculations have been done with deterministic and Monte Carlo approach. The effect of different data libraries used for calculations are discussed as well. 相似文献
113.
Iwona Mazur-Michaek Katarzyna Kowalska Daniel Zielonka Marta Leniczak-Staszak Paulina Pietras Witold Szaflarski Mark Isalan Michal Mielcarek 《International journal of molecular sciences》2022,23(10)
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein. HD-related pathological remodelling has been reported in HD mouse models and HD carriers. In this study, we studied structural abnormalities in the optic nerve by employing Spectral Domain Optical Coherence Tomography (SD-OCT) in pre-symptomatic HD carriers of Caucasian origin. Transmission Electron Microscopy (TEM) was used to investigate ultrastructural changes in the optic nerve of the well-established R6/2 mouse model at the symptomatic stage of the disease. We found that pre-symptomatic HD carriers displayed a significant reduction in the retinal nerve fibre layer (RNFL) thickness, including specific quadrants: superior, inferior and temporal, but not nasal. There were no other significant irregularities in the GCC layer, at the macula level and in the optic disc morphology. The ultrastructural analysis of the optic nerve in R6/2 mice revealed a significant thinning of the myelin sheaths, with a lamellar separation of the myelin, and a presence of myelonoid bodies. We also found a significant reduction in the thickness of myelin sheaths in peripheral nerves within the choroids area. Those ultrastructural abnormalities were also observed in HD photoreceptor cells that contained severely damaged membrane disks, with evident vacuolisation and swelling. Moreover, the outer segment of retinal layers showed a progressive disintegration. Our study explored structural changes of the optic nerve in pre- and clinical settings and opens new avenues for the potential development of biomarkers that would be of great interest in HD gene therapies. 相似文献
114.
115.
Miriam J. Kavec Marketa Urbanova Pavol Makovicky Alena Opattov Kristyna Tomasova Michal Kroupa Klara Kostovcikova Anna Siskova Nazila Navvabi Michaela Schneiderova Veronika Vymetalkova Ludmila Vodickova Pavel Vodicka 《International journal of molecular sciences》2022,23(10)
Oxidative stress, oxidative DNA damage and resulting mutations play a role in colorectal carcinogenesis. Impaired equilibrium between DNA damage formation, antioxidant status, and DNA repair capacity is responsible for the accumulation of genetic mutations and genomic instability. The lesion-specific DNA glycosylases, e.g., hOGG1 and MUTYH, initiate the repair of oxidative DNA damage. Hereditary syndromes (MUTYH-associated polyposis, NTHL1-associated tumor syndrome) with germline mutations causing a loss-of-function in base excision repair glycosylases, serve as straight forward evidence on the role of oxidative DNA damage and its repair. Altered or inhibited function of above glycosylases result in an accumulation of oxidative DNA damage and contribute to the adenoma-adenocarcinoma transition. Oxidative DNA damage, unless repaired, often gives rise G:C > T:A mutations in tumor suppressor genes and proto-oncogenes with subsequent occurrence of chromosomal copy-neutral loss of heterozygosity. For instance, G>T transversions in position c.34 of a KRAS gene serves as a pre-screening tool for MUTYH-associated polyposis diagnosis. Since sporadic colorectal cancer represents more complex and heterogenous disease, the situation is more complicated. In the present study we focused on the roles of base excision repair glycosylases (hOGG1, MUTYH) in colorectal cancer patients by investigating tumor and adjacent mucosa tissues. Although we found downregulation of both glycosylases and significantly lower expression of hOGG1 in tumor tissues, accompanied with G>T mutations in KRAS gene, oxidative DNA damage and its repair cannot solely explain the onset of sporadic colorectal cancer. In this respect, other factors (especially microenvironment) per se or in combination with oxidative DNA damage warrant further attention. Base excision repair characteristics determined in colorectal cancer tissues and their association with disease prognosis have been discussed as well. 相似文献
116.
Gerwin de Haan René Molenaar Michal Koutek Frits H. Post 《Computer Graphics Forum》2007,26(3):695-704
In projection-based Virtual Reality (VR) systems, typically only one headtracked user views stereo images rendered from the correct view position. For other users, who are presented a distorted image, moving with the first user's head motion, it is difficult to correctly view and interact with 3D objects in the virtual environment. In close-range VR systems, such as the Virtual Workbench, distortion effects are especially large because objects are within close range and users are relatively far apart. On these systems, multi-user collaboration proves to be difficult. In this paper, we analyze the problem and describe a novel, easy to implement method to prevent and reduce image distortion and its negative effects on close-range interaction task performance. First, our method combines a shared camera model and view distortion compensation. It minimizes the overall distortion for each user, while important user-personal objects such as interaction cursors, rays and controls remain distortion-free. Second, our method retains co-location for interaction techniques to make interaction more consistent. We performed a user experiment on our Virtual Workbench to analyze user performance under distorted view conditions with and without the use of our method. Our findings demonstrate the negative impact of view distortion on task performance and the positive effect our method introduces. This indicates that our method can enhance the multi-user collaboration experience on close-range, projection-based VR systems. 相似文献
117.
Michal Fila Jan Chojnacki Elzbieta Pawlowska Joanna Szczepanska Cezary Chojnacki Janusz Blasiak 《International journal of molecular sciences》2021,22(18)
Migraine, the leading cause of disability in the population aged below 50, is associated with functional gastrointestinal (GI) disorders (FGIDs) such as functional nausea, cyclic vomiting syndrome, and irritable bowel syndrome (IBS). Conversely, changes in intestinal GI transit may cause diarrhea or constipation and are a component of the autonomic symptoms associated with pre- and post-dorsal phases of migraine attack. These mutual relationships provoke a question on a common trigger in migraine and FGIDs. The kynurenine (l-kyn) pathway (KP) is the major route for l-tryptophan (l-Trp) metabolism and transforms l-Trp into several neuroactive compounds. Changes in KP were reported in both migraine and FGIDs. Migraine was largely untreatable, but several drugs approved lately by the FDA, including monoclonal antibodies for calcitonin gene-related peptide (CGRP) and its receptor, create a hope for a breakthrough in migraine treatment. Derivatives of l-kyn were efficient in pain relief with a mechanism including CGRP inhibition. KP products are important ligands to the aryl hydrocarbon receptor (AhR), whose activation is implicated in the pathogenesis of GI and migraine. Toll-like receptors (TLRs) may play a role in migraine and IBS pathogeneses, and KP metabolites detected downstream of TLR activation may be an IBS marker. The TLR4 signaling was observed in initiating and maintaining migraine-like behavior through myeloid differentiation primary response gene 88 (MyD88) in the mouse. The aim of this review is to justify the view that KP modulation may provide common triggers for migraine and FGIDs with the involvement of TLR, AhR, and MyD88 activation. 相似文献
118.
Petr Matula Pavel Matula Michal Kozubek Vladimír Dvorák 《IEEE transactions on image processing》2006,15(8):2388-2396
Typical time intervals between acquisitions of three-dimensional (3-D) images of the same cell in live cell imaging are in the orders of minutes. In the meantime, the live cell can move in a water basin on the stage. This movement can hamper the studies of intranuclear processes. We propose a fast point-based image registration method for the suppression of the movement of a cell as a whole in the image data. First, centroids of certain intracellular objects are computed for each image in a time-lapse series. Then, a matching between the centroids, which have the maximal number of pairs, is sought between consecutive point sets by a 3-D extension of a two-dimensional fast point pattern matching method, which is invariant to rotation, translation, local distortion, and extra/missing points. The proposed 3-D extension assumes rotations only around the z axis to retain the complexity of the original method. The final step involves computing the optimal fully 3-D transformation between images from corresponding points in the least-squares manner. The robustness of the method was evaluated on generated data. The results of the simulations show that the method is very precise and its correctness can be estimated. This article also presents two practical application examples, namely the registration of images of HP1 domains and the registration of images of telomeres. More than 97% of time-consecutive images were successfully registered. The results show that the method is very well suited to live cell imaging. 相似文献
119.
Nitrification of simulated secondary effluent solution using a variant of the vertical flow bed constructed wetland was studied. In this system oxygen required for the nitrification process is supplied by a passive air pump. The passive air pump is based on a fill and draw cycle, where oxygen depleted air is removed from the system while fresh air is introduced. Each volume of effluent drained is displaced by an equal volume of fresh air. Spatial and temporal oxygen distribution in the system as a function of drained effluent volume was investigated. Experimental results of nitrification and the corresponding oxygen consumption show good agreement with theoretical calculations based on physico–chemical considerations. Observations show that while oxygen distribution within the media was found to be non-uniform at the beginning of each cycle, it approached more uniform distribution with time. The latter resulted mainly from diffusion of oxygen in the gaseous phase. 相似文献
120.
In this paper the risk associated with deposition of aerosol (“hygroscopic dust”) on printed circuit boards is assessed for different equipment designs and deployment. The amount of deposited dust is related to (1) the total dust availability in a given type of equipment and (2) to the rate of deposition of dust due to different mechanisms. Of these, the Brownian diffusion, gravitational settling, thermophoresis and electrophoresis are of different relative importance depending on such design factors as air flow in the enclosure, temperature gradients between boards and walls and presence of electric fields. The expressions for electric fields in the vicinity of printed circuit boards relevant to electrophoretic deposition are derived. It is shown that not only the sealed Absolute Humidity Control Modules but also the breathing Relative Humidity Control Modules should not present a hygroscopic dust risk for either indoor or outdoor applications. Direct air cooled system with forced convection present a definite dust reliability risk both for indoor and outdoor applications while open natural convection cooled systems present a borderline case where each design has to be considered separately. 相似文献