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41.
Mischak H Kolch W Aivaliotis M Bouyssié D Court M Dihazi H Dihazi GH Franke J Garin J Gonzalez de Peredo A Iphöfer A Jänsch L Lacroix C Makridakis M Masselon C Metzger J Monsarrat B Mrug M Norling M Novak J Pich A Pitt A Bongcam-Rudloff E Siwy J Suzuki H Thongboonkerd V Wang LS Zoidakis J Zürbig P Schanstra JP Vlahou A 《Proteomics. Clinical applications》2010,4(4):464-478
42.
Maret G. Traber Michalis Rallis Maurizio Podda Christine Weber Howard I. Maibach Lester Packer 《Lipids》1998,33(1):87-91
To evaluate skin penetration of various vitamin E homologs, a 5% solution of either α-tocopherol, α-tocotrienol, or γ-tocotrienol
in polyethylene glycol was topically applied to SKH-1 hairless mice. After 0.5, 1, 2, or 4 h (n=four per time point and four per vitamin E homolog), the skin was washed, the animals killed, the skin rapidlly removed,
frozen on dry ice, and a biopsy taken and sectioned: stratum corneum (two uppermost, 5-μm sections—SC1 and SC2), epidermis
(next two 10μm sections—E1 and E2), papillary dermis (next 100μ, PD), dermis (next 400 μm, D), and subcutaneous fat (next
100 μm, SF). SC1 contained the highest vitamin E concentrations per μ thickness. To compare the distribution of the various
vitamin E forms into the skin layers, the percentage of each form was expressed per its respective total. Most surprising
was that the largest fraction of skin vitamin E following topical application was found in the deeper subcutaneous layers—the
lowest layers, PD (40±15%) and D (36±15%), contained the major portion of the applied vitamin E forms. Although PD only represents
about 16% of the total skin thickness, it contains sebaceous glands—lipid secretory organs, and, thus, may account for the
vitamin E affinity for this layer. Hence, applied vitamin E penetrates rapidly through the skin, but the highest concentrations
are found in the uppermost 5 microns. 相似文献
43.
Linninger AA Tsakiris C Zhu DC Xenos M Roycewicz P Danziger Z Penn R 《IEEE transactions on bio-medical engineering》2005,52(4):557-565
Disturbances of the cerebrospinal fluid (CSF) flow in the brain can lead to hydrocephalus, a condition affecting thousands of people annually in the US. Considerable controversy exists about fluid and pressure dynamics, and about how the brain responds to changes in flow patterns and compression in hydrocephalus. This paper presents a new model based on the first principles of fluid mechanics. This model of fluid-structure interactions predicts flows and pressures throughout the brain's ventricular pathways consistent with both animal intracranial pressure (ICP) measurements and human CINE phase-contrast magnetic resonance imaging data. The computations provide approximations of the tissue deformations of the brain parenchyma. The model also quantifies the pulsatile CSF motion including flow reversal in the aqueduct as well as the changes in ICPs due to brain tissue compression. It does not require the existence of large transmural pressure differences as the force for ventricular expansion. Finally, the new model gives an explanation of communicating hydrocephalus and the phenomenon of asymmetric hydrocephalus. 相似文献
44.
We consider data that are images containing views of multiple objects. Our task is to learn about each of the objects present in the images. This task can be approached as a factorial learning problem, where each image must be explained by instantiating a model for each of the objects present with the correct instantiation parameters. A major problem with learning a factorial model is that as the number of objects increases, there is a combinatorial explosion of the number of configurations that need to be considered. We develop a method to extract object models sequentially from the data by making use of a robust statistical method, thus avoiding the combinatorial explosion, and present results showing successful extraction of objects from real images. 相似文献
45.
Michalis D. Galanis Gregory Dimitroulakos Costas E. Goutis 《The Journal of supercomputing》2006,38(1):17-34
A partitioning methodology between the reconfigurable hardware blocks of different granularity, which are embedded in a generic
heterogeneous architecture, is presented. The fine-grain reconfigurable logic is realized by an FPGA unit, while the coarse-grain
reconfigurable hardware by a 2-Dimensional Array of Processing Elements. Critical parts, called kernels, are mapped on the
coarse-grain reconfigurable logic for improving performance. The partitioning method is mainly composed by three steps: the
analysis of the input code, the mapping onto the Coarse-Grain Reconfigurable Array and the mapping onto the FPGA. The partitioning
flow is implemented by a prototype software framework. Analytical partitioning experiments, using five real-world applications,
show that the execution time speedup relative to an all-FPGA solution ranges from 1.4 to 5.0. 相似文献
46.
Michalis A. Savelonas Eleftheria A. Mylona Dimitris Maroulis 《Pattern recognition》2012,45(2):720-731
This work introduces a novel active contour-based scheme for unsupervised segmentation of protein spots in two-dimensional gel electrophoresis (2D-GE) images. The proposed segmentation scheme is the first to exploit the attractive properties of the active contour formulation in order to cope with crucial issues in 2D-GE image analysis, including the presence of noise, streaks, multiplets and faint spots. In addition, it is unsupervised, providing an alternate to the laborious, error-prone process of manual editing, which is required in state-of-the-art 2D-GE image analysis software packages. It is based on the formation of a spot-targeted level-set surface, as well as of morphologically-derived active contour energy terms, used to guide active contour initialization and evolution, respectively. The experimental results on real and synthetic 2D-GE images demonstrate that the proposed scheme results in more plausible spot boundaries and outperforms all commercial software packages in terms of segmentation quality. 相似文献
47.
Growth Capacity of a Novel Potential Probiotic Lactobacillus paracasei K5 Strain Incorporated in Industrial White Brined Cheese as an Adjunct Culture
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48.
In this paper, the influence of the kind of raw materials which are (or can be) used in Greece for industrial production of ethanol on the characteristics of liquid and gas wastes has been studied. Raisin and molasses, which are used today, as well as straw and sugar beets which have been proposed recently, have been examined. From this study, it was found that the more suitable raw material from the point of view of air and water pollution is the sugar beet. 相似文献
49.
Stylianou MA Hadjiconstantinou MP Inglezakis VJ Moustakas KG Loizidou MD 《Journal of hazardous materials》2007,143(1-2):575-581
This work deals with the removal of lead, copper and zinc from aqueous solutions by using natural zeolite (clinoptilolite). Fixed bed experiments were performed, using three different volumetric flow rates of 5, 7 and 10bed volume/h, under a total normality of 0.01N, at initial pH of 4 and ambient temperature (25 degrees C). The removal efficiency increased when decreasing the flow rate and the following selectivity series was found: Pb(2+)>Zn(2+)> or =Cu(2+). Conductivity measurements showed that lead removal follows mainly ion exchange mechanism, while copper and zinc removal follows ion exchange and sorption mechanism as well. 相似文献
50.
Nikos G. Gavalas Michalis Liontos Sofia-Paraskevi Trachana Tina Bagratuni Calliope Arapinis Christine Liacos Meletios A. Dimopoulos Aristotle Bamias 《International journal of molecular sciences》2013,14(8):15885-15909
Ovarian Cancer represents the most fatal type of gynecological malignancies. A number of processes are involved in the pathogenesis of ovarian cancer, especially within the tumor microenvironment. Angiogenesis represents a hallmark phenomenon in cancer, and it is responsible for tumor spread and metastasis in ovarian cancer, among other tumor types, as it leads to new blood vessel formation. In recent years angiogenesis has been given considerable attention in order to identify targets for developing effective anti-tumor therapies. Growth factors have been identified to play key roles in driving angiogenesis and, thus, the formation of new blood vessels that assist in “feeding” cancer. Such molecules include the vascular endothelial growth factor (VEGF), the platelet derived growth factor (PDGF), the fibroblast growth factor (FGF), and the angiopoietin/Tie2 receptor complex. These proteins are key players in complex molecular pathways within the tumor cell and they have been in the spotlight of the development of anti-angiogenic molecules that may act as stand-alone therapeutics, or in concert with standard treatment regimes such as chemotherapy. The pathways involved in angiogenesis and molecules that have been developed in order to combat angiogenesis are described in this paper. 相似文献