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21.
S Petrasch LJ van Tits HJ Motulsky OE Brodde MC Michel 《Canadian Metallurgical Quarterly》1993,43(8):904-908
The effects of the antiasthmatic drug ketotifen (CAS 34580-13-7) on human mononuclear leukocytes were studied in vitro and in vivo. In vitro ketotifen concentration-dependently inhibited mitogen-stimulated lymphocyte proliferation. High ketotifen concentrations also inhibited T-lymphocyte mitogen- and adenosine triphosphate stimulated increases in intracellular Ca2+ in lymphocytes and the U937 human monocyte precursor cell line, respectively; this involved inhibition of both Ca2+ influx and intracellular mobilization. In in vivo experiments, treatment of healthy volunteers with 1 mg ketotifen b.i.d. for 7 d did not alter the number or subset composition of circulating lymphocytes. Moreover, the mitogen-stimulated in vitro proliferation of lymphocytes obtained before and after ketotifen treatment in vivo was similar. It is concluded that high ketotifen concentrations can inhibit the activation of resting lymphocytes in vitro but standard ketotifen treatment does not notably affect the number of function of circulating lymphocytes in vivo. 相似文献
22.
Zitt Michel Ramanana-Rahary Suzy Bassecoulard Elise Laville Françoise 《Scientometrics》2003,57(2):295-320
This article depicts some features of the geography of science and technology outputs in the EU, with a particular attention
to regional “co-location” of these two pillars of the “knowledge-based society”. Economists have, for a decade, paid great
attention to local “spillovers” stating that industrial firms often draw advantages from the presence of nearby academic centres.
The presence in the same areas of strong academic and technological resources is both a condition and a result of science-technology
interactions. Concentrating on publications and patents as proxies of the science and technology level in regions, we built
a typology of regions according to their commitment to the two knowledge-base activities and then analysed the co-locations
of science and technology from several points of view. A fine-grain lattice, mainly based on standard Nuts3 level, was used.
Co-location, at the EU level, is not a general rule. A strong potential for spillover/ interaction does exist in the top-class
regions which concentrate a high proportion of European S and T output. But for regions with a small/medium level of S&T activity,
a divergence of orientations appears between a science-oriented family and a technology-oriented family, indicating an imbalance
between local S and T resources. If we look at the S-oriented regions, whilst controlling for underlying factors, such as
population and regional economic product, a significant geographic linkage between T and S appears. This suggests a trajectory
of science-based technological development. A careful examination of S&T thematic alignments and specialisation is necessary
to develop the hypothesis that fostering academic resources could increase the technological power along a growth path.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
23.
When one wants to understand and model the drying of high water content gels, one needs to gather all thermal physical parameters and to derive a physical model based on independently measured parameters. We chose to work experimentally and theoretically on water diffusion and drying of spheres of polyacrylamide gel.
We have demonstrated the strong influence of vitreous transition on the relationship of water diffusivity with moisture content. Values of the diffusion coefficient and temperature shift factor for diffusion have been proposed.
Convective and micro-wave drying kinetics show the presence of a drying phase purely specific to radiation absorption. Finally, we have proposed a mathematical model containing independent physical parameters, which' not only predicts mass fluxes but also analyses critical physical phenomena. 相似文献
We have demonstrated the strong influence of vitreous transition on the relationship of water diffusivity with moisture content. Values of the diffusion coefficient and temperature shift factor for diffusion have been proposed.
Convective and micro-wave drying kinetics show the presence of a drying phase purely specific to radiation absorption. Finally, we have proposed a mathematical model containing independent physical parameters, which' not only predicts mass fluxes but also analyses critical physical phenomena. 相似文献
24.
Charbel Farhat Michel Lesoinne 《International journal for numerical methods in engineering》1993,36(5):745-764
Most of the recently proposed computational methods for solving partial differential equations on multiprocessor architectures stem from the 'divide and conquer' paradigm and involve some form of domain decomposition. For those methods which also require grids of points or patches of elements, it is often necessary to explicitly partition the underlying mesh, especially when working with local memory parallel processors. In this paper, a family of cost-effective algorithms for the automatic partitioning of arbitrary two- and three-dimensional finite element and finite difference meshes is presented and discussed in view of a domain decomposed solution procedure and parallel processing. The influence of the algorithmic aspects of a solution method (implicit/explicit computations), and the architectural specifics of a multiprocessor (SIMD/MIMD, startup/transmission time), on the design of a mesh partitioning algorithm are discussed. The impact of the partitioning strategy on load balancing, operation count, operator conditioning, rate of convergence and processor mapping is also addressed. Finally, the proposed mesh decomposition algorithms are demonstrated with realistic examples of finite element, finite volume, and finite difference meshes associated with the parallel solution of solid and fluid mechanics problems on the iPSC/2 and iPSC/860 multiprocessors. 相似文献
25.
Michel Dorbon Pierre Henri Bigeard Jacques Denis Christian Bernasconi 《Petroleum Science and Technology》1992,10(8):1313-1341
As established by several previous works, nitrogen compounds play a prominent role in the evolution of middle distillates containing cracked components, particularly regarding sediment formation and color evolution.
In a first part, this paper describes and compares stability properties of fuel blends using both an accelerated ageing method at 120°C (248°F ) and long term storage methods at 43°C(110°F) -ASTM 0 4625 - and at ambient temperature. Effectiveness of stabilizing additives is also evaluated. In mixtures containing LCOs, insoluble products are formed progressively during ageings, more or less rapidly according to the chemical constitution of the mixtures.
Then, it reports the complete identification of nitrogen compounds using gas chromatography equipped with a selective nitrogen detector and mass spectrometry showing that in light cycle oils, alkyl indoles and carbazoles are the main families.
Evolution of these compounds was followed kinetically during ageings in absence and presence of additives and alkyl indoles appeared as the moat evolutionary.
It appeared that some additives avoided evolutions of alkyl indoles without preventing sediment formation and color evolution. Oxidation mechanism involving nitrogen compounds should not be the only one to explain the storage evolutions of middle distillates.
Hydrotreatment converts all the alkyl indoles of LCO and prevents coloration end deposits in the storage of the mixtures of steaight-run distillates and LCOs. 相似文献
In a first part, this paper describes and compares stability properties of fuel blends using both an accelerated ageing method at 120°C (248°F ) and long term storage methods at 43°C(110°F) -ASTM 0 4625 - and at ambient temperature. Effectiveness of stabilizing additives is also evaluated. In mixtures containing LCOs, insoluble products are formed progressively during ageings, more or less rapidly according to the chemical constitution of the mixtures.
Then, it reports the complete identification of nitrogen compounds using gas chromatography equipped with a selective nitrogen detector and mass spectrometry showing that in light cycle oils, alkyl indoles and carbazoles are the main families.
Evolution of these compounds was followed kinetically during ageings in absence and presence of additives and alkyl indoles appeared as the moat evolutionary.
It appeared that some additives avoided evolutions of alkyl indoles without preventing sediment formation and color evolution. Oxidation mechanism involving nitrogen compounds should not be the only one to explain the storage evolutions of middle distillates.
Hydrotreatment converts all the alkyl indoles of LCO and prevents coloration end deposits in the storage of the mixtures of steaight-run distillates and LCOs. 相似文献
26.
Auguste Commeyras Hlne Collet Laurent Boiteau Jacques Taillades Odile Vandenabeele‐Trambouze Herv Cottet Jean‐Philippe Biron Raphaël Plasson Louis Mion Olivier Lagrille Herv Martin Franck Selsis Michel Dobrijevic 《Polymer International》2002,51(7):661-665
Addressing the still open question of the prebiotic origin of sequential macromolecules (peptides, nucleic acids) on the primitive Earth, we describe a molecular engine (the primary pump), which works at ambient temperature and continuously generates, elongates and complexifies sequential peptides. This new scenario is based on a cyclic reaction sequence, whose keystep is the activation of amino acids into their N‐carboxyanhydrides (NCA) through nitrosation by NOx. This process could have taken place on tidal beaches; it requires a buffered ocean, emerged land and a nitrosating atmosphere. With the help of geochemical studies and computer simulations of atmosphere photochemistry, we show that the primitive Earth during the Hadean may have satisfied all these requirements. © 2001 Society of Chemical Industry. 相似文献
27.
B. Raveau C. Michel M. Hervieu D. Groult A. Maignan J. Provost 《Journal of Superconductivity and Novel Magnetism》1992,5(3):203-217
Different ways to optimizeT c 's and the magnetic properties of high-T c superconductive cuprates are described and discussed. Oxygen intercalation-desintercalation phenomena and cationic substitutions (M3+ for M2+ or vice versa) lead to a variation of the hole carrier density and can have a drastic influence onT c 's, as shown for bismuth, thallium, and lead-based cuprates, as well as for La2CuO4 and “123”-type superconductors. In the former, the role of hole reservoirs for the rock salt type layers is outlined. The modification of the hybridization of orbitals can also explain the variations ofT c 's observed in some systems like Y1?x Ca x Ba2Cu3?x :Fe x O7 in which the oxidation state of copper remains constant. A critical current density enhancement can be realized by irradiating high-T c materials by high-energy heavy ions because of the peculiar columnar structure of the heavy ion-induced tracks. The effects of such columnar defects, 70 Å in diameter, on flux pinning, magnetic relaxation, and location of the irreversibility line of bismuth-based 2212 crystals irradiated by 6-GeV Pb ions are reported. We observe a strong shift of the irreversibility line toward high fields and temperatures, indicating that pinning effects must be taken into account in the vortex lattice motion. Such induced changes are accompanied by a strong enhancement of the critical current density and a significant enlargement of the irreversibility region in theH,T plane. 相似文献
28.
29.
F. Adrian M. Rü bsam K. -P. Dinse D. Fuchs H. Rietschel R. H. Michel M. Benz M. M. Kappes 《Fullerenes, Nanotubes and Carbon Nanostructures》1996,4(4):655-675
From the analysis of the temperature dependence of the EPR line width, an estimate of the anisotropic parts of the dipolar and quadrupolar hyperfine couplings of lanthanum was derived. Furthermore, the rotational correlation time of the nearly spherical molecule was found to deviate considerably from that of the solvent molecules. 相似文献
30.
CE Michel 《Canadian Metallurgical Quarterly》1996,114(9):1134-5; discussion 1135