Golden interfaces: The Surface of Self-Assembled Monolayers

Self-assembled monolayers (SAMs) of alkanethiols and disulfides on gold form organic interfaces with properties largely controlled by the end groups of the molecules composing the film. SAMs provide a unique link between the science of organic surfaces and technologies that seek to exploit their adaptable character. Many techniques are useful for probing the structure of SAMs although only scanning tunneling microscopy (STM) at picoamperes reveals the details of the packing of their end groups at the sub-angstrom level. This review demonstrates that STM effectively tests new types of control over the microscopic structure–property relationships characteristic of SAMs on gold that should prove useful to their application.     

Mine operating accurate stability control with optical fibersensing and Bragg grating technology: the European BRITE/EURAM STABILOSproject

Recent developments of stability control in mines, essentially based on Ge-doped fiber Bragg gratings (FBG) are reported including results about the different aspects of the system: accurate characterizations of FBG, sensor network topology and multiplexing method, user interface design and sensor packaging     

Standards and industrial property

This article is primarily concerned with standards seen as a means for collective appropriation of technological information. It begins with an attempt to throw light on the relationships between standards, patents and licenses. Then we develop a two-stage duopolistic model whereby each firm must decide on a programme of standardization before choosing its level of production. The risks of multiple or inefficient equilibria are strong enough to justify the intervention of standardization organizations to inform and coordinate individual firms. But the paper also explains why some organizations likeetsi try to play a new role by promoting open access to master patents when used in the definition of a standard.     

Algorithmen zur Pulsweitenmodulation für Wechselrichter mit in Echtzeit berechnetem Pulsmuster

Übersicht Mit Hinblick auf die zunehmend Verbreitung findende Pulsmusterberechnung in Echtzeit werden in dem Aufsatz Gesichtspunkte diskutiert, die sich aus den Eigenschaften des leistungselektronischen Stellgliedes, des Pulswechselrichters, ergeben. Die bei Abtastregelungen für die Dauer einer Abtastperiode konstante Stellgröße muß bei ihm durch Pulsweitenmodulation in ein Pulsmuster mit konstanter Amplitude und Pulsen variabler Breite umgesetzt werden. Durch ein neues Verfahren mit versetzter Abtastung haben dabei Rechentotzeiten bis zur Dauer einer halben Abtastperiode keinen Einfluß mehr auf das Pulsmuster.

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Algorithms for pulswidth modulation of inverters with online calculated pulse patterns

Contents Online calculation of pulse patterns will be employed more intensively in the future. Aspects concerning the powereleotronic circuit, the pulsewidth-modulated inverter, are to be discussed. The set value being constant for the duration of a sampling interval, has to be converted by a modulation algorithm into a pulse pattern with constant amplitude and pulses of variable width. Calculation dead-times up to half of sampling interval have no influence on the pulse pattern when using a new algorthm with shifted sampling instants.

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Herrn Prof. Dr.-Ing. Klemens Heumann zum 60. Geburtstag gewidmet     

Benign glandular inclusions in inguinal and abdominopelvic lymph nodes in gynecologic pathology

From 4 cases recently seen at the Institut Gustave-Roussy, this report describes the pathological and evolutive features of benign glandular inclusions in inguinal, pelvic or abdominal lymph nodes. These lesions are defined by the presence of tubular formations in lymph nodes, lined by a single layer of epithelium which is cuboidal or columnar and resembled that of tubal epithelium with ciliated, secretory and intercalary cells. In most cases, benign glandular inclusions in lymph nodes still quiescent. In rare instances, they may proliferate and become papillary. The association of proliferating glandular inclusions in lymph nodes with borderline tumor of the ovary raises the problem of their primary or metastatic origin. However, their pathological features argues for a primary origin in lymph nodes. Thus, we think that a metastatic potential of borderline tumors of the ovary is not supported by any convincing argument.     

Effects of ketotifen on human lymphocytes in vitro and in vivo

The effects of the antiasthmatic drug ketotifen (CAS 34580-13-7) on human mononuclear leukocytes were studied in vitro and in vivo. In vitro ketotifen concentration-dependently inhibited mitogen-stimulated lymphocyte proliferation. High ketotifen concentrations also inhibited T-lymphocyte mitogen- and adenosine triphosphate stimulated increases in intracellular Ca2+ in lymphocytes and the U937 human monocyte precursor cell line, respectively; this involved inhibition of both Ca2+ influx and intracellular mobilization. In in vivo experiments, treatment of healthy volunteers with 1 mg ketotifen b.i.d. for 7 d did not alter the number or subset composition of circulating lymphocytes. Moreover, the mitogen-stimulated in vitro proliferation of lymphocytes obtained before and after ketotifen treatment in vivo was similar. It is concluded that high ketotifen concentrations can inhibit the activation of resting lymphocytes in vitro but standard ketotifen treatment does not notably affect the number of function of circulating lymphocytes in vivo.     

Potential science-technology spillovers in regions: An insight on geographic co-location of knowledge activities in the EU

This article depicts some features of the geography of science and technology outputs in the EU, with a particular attention to regional “co-location” of these two pillars of the “knowledge-based society”. Economists have, for a decade, paid great attention to local “spillovers” stating that industrial firms often draw advantages from the presence of nearby academic centres. The presence in the same areas of strong academic and technological resources is both a condition and a result of science-technology interactions. Concentrating on publications and patents as proxies of the science and technology level in regions, we built a typology of regions according to their commitment to the two knowledge-base activities and then analysed the co-locations of science and technology from several points of view. A fine-grain lattice, mainly based on standard Nuts3 level, was used. Co-location, at the EU level, is not a general rule. A strong potential for spillover/ interaction does exist in the top-class regions which concentrate a high proportion of European S and T output. But for regions with a small/medium level of S&T activity, a divergence of orientations appears between a science-oriented family and a technology-oriented family, indicating an imbalance between local S and T resources. If we look at the S-oriented regions, whilst controlling for underlying factors, such as population and regional economic product, a significant geographic linkage between T and S appears. This suggests a trajectory of science-based technological development. A careful examination of S&T thematic alignments and specialisation is necessary to develop the hypothesis that fostering academic resources could increase the technological power along a growth path. This revised version was published online in August 2006 with corrections to the Cover Date.     

MODELISATION PRINCIPLES FOR DRYING OF GELS

When one wants to understand and model the drying of high water content gels, one needs to gather all thermal physical parameters and to derive a physical model based on independently measured parameters. We chose to work experimentally and theoretically on water diffusion and drying of spheres of polyacrylamide gel.

We have demonstrated the strong influence of vitreous transition on the relationship of water diffusivity with moisture content. Values of the diffusion coefficient and temperature shift factor for diffusion have been proposed.

Convective and micro-wave drying kinetics show the presence of a drying phase purely specific to radiation absorption. Finally, we have proposed a mathematical model containing independent physical parameters, which' not only predicts mass fluxes but also analyses critical physical phenomena.