Spin-Crossover Grafted Monolayer of a Co(II) Terpyridine Derivative Functionalized with Carboxylic Acid Groups

The synthesis and characterization of a new Co(II) spin-crossover (SCO) complex based on 4′-(4-carboxyphenyl)−2,2′:6′,2″-terpyridine ligand are reported. This complex can be successfully grafted on silver surface maintaining the SCO behavior. Thus, atomic force microscopy (AFM), matrix assisted laser desorption ionization – time-of-flight mass spectrometry (MALDI-TOF MS), Raman spectroscopy, and XPS measurements, upon surface deposition, evidence the formation of a monolayer of intact molecules grafted through carboxylate groups to the Ag surface. Three different techniques: Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and X-ray absorption spectroscopy (XAS), supported by first-principles calculations, confirm that the deposited molecules undergo a gradual spin transition with temperature. This phenomenon is unprecedented for a monolayer of molecules directly grafted onto a metallic surface from solution.     

Reconstructing the 3D shape and bone mineral density distribution of the proximal femur from dual-energy X-ray absorptiometry

The accurate diagnosis of osteoporosis has gained increasing importance due to the aging of our society. Areal bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is an established criterion in the diagnosis of osteoporosis. This measure, however, is limited by its two-dimensionality. This work presents a method to reconstruct both the 3D bone shape and 3D BMD distribution of the proximal femur from a single DXA image used in clinical routine. A statistical model of the combined shape and BMD distribution is presented, together with a method for its construction from a set of quantitative computed tomography (QCT) scans. A reconstruction is acquired in an intensity based 3D-2D registration process whereby an instance of the model is found that maximizes the similarity between its projection and the DXA image. Reconstruction experiments were performed on the DXA images of 30 subjects, with a model constructed from a database of QCT scans of 85 subjects. The accuracy was evaluated by comparing the reconstructions with the same subject QCT scans. The method presented here can potentially improve the diagnosis of osteoporosis and fracture risk assessment from the low radiation dose and low cost DXA devices currently used in clinical routine.     

Highly linear 2.5-V CMOS /spl Sigma//spl Delta/ modulator for ADSL+

We present a 90-dB spurious-free dynamic range sigma-delta modulator (/spl Sigma//spl Delta/M) for asymmetric digital subscriber line applications (both ADSL and ADSL+), with up to a 4.4-MS/s digital output rate. It uses a cascade (MASH) multibit architecture and has been implemented in a 2.5-V supply, 0.25-/spl mu/m CMOS process with metal-insulator-metal capacitors. The prototypes feature 78-dB dynamic range (DR) in the 30-kHz to 2.2-MHz band (ADSL+) and 85-dB DR in the 30-kHz to 1.1-MHz band (ADSL). Integral and differential nonlinearity are within /spl plusmn/0.85 and /spl plusmn/0.80 LSB/sub 14 b/, respectively. The /spl Sigma//spl Delta/ modulator and its auxiliary blocks (clock phase and reference voltage generators, and I/O buffers) dissipate 65.8 mW. Only 55 mW are dissipated in the /spl Sigma//spl Delta/ modulator.     

Stable droplets and dark-ring cavity solitons in nonlinear optical devices

Two kinds of cavity solitons, stable circular domain walls (droplets) and dark-ring cavity solitons, are presented in models of vectorial Kerr resonators and degenerate optical parametric oscillators. These structures are universal in systems with two equivalent homogeneous states and are found for parameter values close to those of a modulational instability of a flat front. Stable droplets owe their existence to curvature effects and, therefore, they are not present in one-dimensional systems. We show that stable droplets nucleate out of dark-ring cavity solitons and that in some systems there are regimes in which they coexist.     

Engineering DNA-Grafted Quatsomes as Stable Nucleic Acid-Responsive Fluorescent Nanovesicles

The development of artificial vesicles into responsive architectures capable of sensing the biological environment and simultaneously signaling the presence of a specific target molecule is a key challenge in a range of biomedical applications from drug delivery to diagnostic tools. Herein, the rational design of biomimetic DNA-grafted quatsome (QS) nanovesicles capable of translating the binding of a target molecule to amphiphilic DNA probes into an optical output is presented. QSs are synthetic lipid-based nanovesicles able to confine multiple organic dyes at the nanoscale, resulting in ultra-bright soft materials with attractiveness for sensing applications. Dye-loaded QS nanovesicles of different composition and surface charge are grafted with fluorescent amphiphilic nucleic acid-based probes to produce programmable FRET-active nanovesicles that operate as highly sensitive signal transducers. The photophysical properties of the DNA-grafted nanovesicles are characterized and the highly selective, ratiometric detection of clinically relevant microRNAs with sensitivity in the low nanomolar range are demonstrated. The potential applications of responsive QS nanovesicles for biosensing applications but also as functional nanodevices for targeted biomedical applications is envisaged.     

Elimination of Fresnel Reflection Boundary Effects and Beam Steering in Pulsed Terahertz Computed Tomography

For the past few decades there has been tremendous innovation and development of Terahertz (THz) science and imaging. In particular, the technique of 3-D computed tomography has been adapted from the X-Ray to the THz range. However, the finite refractive index of materials in the THz range can severally refract probing THz beams during the acquisition of tomography data. Due to Fresnel reflection power losses at the boundaries as well as steering of the THz beam through the sample, refractive effects lead to anomalously high local attenuation coefficients near the material boundaries of a reconstructed image. These boundary phenomena can dominate the reconstructed THz-CT images making it difficult to distinguish structural defect(s) inside the material. In this paper an algorithm has been developed to remove the effects of refraction in THz-CT reconstructed images. The algorithm is successfully implemented on cylindrical shaped objects.     

On the Impact of Ultra Wide Band (UWB) on Macrocell Downlink of CDMA-PCS System

In this paper, we present an analytical model to quantify the effect of the Ultra-Wide Band (UWB) transmitters on the CDMA-PCS downlink range and normalized capacity. The effect is given for different configuration and environments. Our analysis shows that, for a single UWB transmitter, an UWB power density of −78dBm/MHz is the maximum permitted power density to have only PCS macrocell capacity reduction of 1% when the distance between the PCS mobile and the UWB transmitter is 1 m. For the multiple UWB transmitters case, a power density of −80dBm/MHz, is the maximum permitted power density to have only PCS macrocell capacity reduction of 1% when the distance between the PCS mobile and the UWB transmitter is 1 m.     

CWDM Metropolitan Multiple-Access Ring Network Based on Optical Packet Witching

We present a novel CWDM metropolitan multiple-access ring network based on optical switching of packets according to their wavelength. Each node within the MAN is identified by a combination of wavelength and numerical address. Hence, nodes are able to drop packets presenting a particular wavelength and numerical address, but can insert packets in any wavelength into the ring. This configuration allows wavelength sharing, as several nodes are identified by the same wavelength (but different numerical addresses), and simplifies switching requirements since the set of numerical addresses is reduced. We analyze the viability and scalability of such a network, determining the number of nodes supported by the network under different traffic scenarios and wavelength resources. The impact of switching time on network performance is also analyzed in order to determine which switching technology should be employed when implementing the network. An erratum to this article is available at .     

Impact of the radio channel modelling on the performance of?VANET communication protocols

The expected traffic safety and efficiency benefits that can be achieved through the development and deployment of vehicular ad-hoc networks has attracted a significant interest from the networking research community that is currently working on novel vehicular communication protocols. The time-critical nature of vehicular applications and their reliability constraints require a careful protocol design and dimensioning. To this aim, adequate and accurate models should be employed in any research study. One of the critical aspects of any wireless communications system is the radio channel propagation. This is particularly the case in vehicular networks due to their low antenna heights, the fast topology changes and the reliability and latency constraints of traffic safety applications. Despite the research efforts to model the vehicle-to-vehicle communications channel, many networking studies are currently simplifying and even neglecting the radio channel effects on the performance and operation of their protocols. As this work demonstrates, it is critical that realistic and accurate channel models are employed to adequately understand, design and optimize novel vehicular communications and networking protocols.