Structure formation and properties of corundum ceramics based on metastable aluminium oxide doped with stabilized zirconium dioxide

The work presents a successful example of the use of YSZ binary systems for production of composite ceramic materials based on θ-Al₂O₃ with improved physical and mechanical characteristics which was previously considered an unpromising material. It was first obtained result of extreme nature of dependence of physical and mechanical properties of Al₂O₃+YSZ on the concentration of YSZ (ZrO₂–3mol% of Y₂O₃) additive. The sintering temperature was decreased on 250 °C (from 1800 to 1550 °C). The phase composition of powders and the structure of ceramics of the Al₂O₃ + YSZ system were investigated depending on the amount of YSZ dopant, the structure-properties relationship was established. It is shown that maximum of physical and mechanical characteristics achieved at YSZ concentration equal to 10% wt.     

Understanding NFC-Net: a deep learning approach to word-level handwritten Indic script recognition

Neural Computing and Applications - This paper presents a deep learning architecture modified for resource-constrained environments, called Non-Fully-Connected Network or NFC-Net, based on...     

Sliding Mode Control For Invertible Systems Based On A Direct Design Of Interactors

The sliding mode tracking control is reviewed and extended so that it can be applicable to general invertible systems. The main advantage of this paper is a direct and numerical stable design of interactors for general invertible systems which is performed by calculating infinite eigenbasis of system matrices.     

Inhibitory guanine-nucleotide-binding-regulatory protein alpha subunits in medaka (Oryzias latipes) oocytes--cDNA cloning and decreased expression of proteins during oocyte maturation

We have previously shown that pertussis-toxin-sensitive inhibitory guanine-nucleotide-binding-regulatory proteins (G proteins) are involved in the signal transduction of steroidal maturation-inducing hormone (MIH) of rainbow trout (Oncorhynchus mykiss) oocytes, 17alpha,20beta-dihydroxy-4-pregnen-3-one (17alpha,20beta-DP) [Yoshikuni, M. & Nagahama, Y. (1994) Dev. Biol. 166, 615-622]. In this study, we obtained five different cDNA fragments of G protein alpha subunits from medaka (Oryzias latipes) intact ovarian follicles (three subtypes of G(i alpha), G(i alpha a), G(i alpha b) and G(i alpha c); two subtypes of G(s alpha), G(s alpha d), and G(s alpha e)). Using a newly developed extraction method for medaka oocyte RNA, we demonstrated that oocytes expressed both G(i alpha a) and G(i alpha c), but not G(i alpha b). Full-length cDNA clones for G(i alpha a) and G(i alpha c) were then isolated from a medaka ovarian follicle cDNA library. The predicted amino acid sequences of G(i alpha a) and G(i alpha c) exhibited significant similarity with G(i alpha1) and G(i alpha2) of other species, respectively. Both G(i alpha a) and G(i alpha c) possessed a specific Cys residue in the C-terminal region that was the site for ADP-ribosylation by pertussis toxin. G(o alpha), another G protein that is ADP-ribosylated by pertussis toxin, was not detected in oocytes, although it was expressed in brain tissue. Western blot analyses using a specific antibody against G(i alpha1) and G(i alpha2) subunit proteins revealed that in both medaka and rainbow trout G(i alpha) subunit protein (40 kDa) contents were abundant in plasma membranes of postvitellogenic immature oocytes, decreased in mature oocytes, and were absent in ovulated eggs. Furthermore, specific 17alpha,20beta-DP binding to plasma membranes was higher in postvitellogenic immature oocytes than in ovulated eggs. Taken together, these results suggest that G(i alpha a) and/or G(i alpha c) may be involved in the transduction of the signal from 17alpha,20beta-DP receptors during oocyte maturation of fish oocytes.     

Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics

Catechol-O-methyltransferase (COMT) is an enzyme which inactivates catecholamine neurotransmitters by methylation, and is considered a candidate for involvement in schizophrenia. A functional COMT gene polymorphism influencing the enzyme activities, the high activity (val-108) and the low activity allele (met-108), was recently confirmed. We investigated a genetic association between schizophrenia and the COMT gene polymorphism in 150 Japanese schizophrenics and controls. We detected the low activity met-108 allele more frequently in schizophrenics than in the controls, and found that subjects sharing the met-108 allele (val/met and met/met) are significantly more common in the patients than in the controls. The results suggest that the low activity met-108 allele may be involved in susceptibility for schizophrenia.     

Relationship of atopic dermatitis to residential environment. A study of the comparison between diagnosis by medical examination and assessment by questionnaire]

Diagnosis of atopic dermatitis (AD) according to criterion of the Japanese Dermatology Society by medical examination and a questionnaire survey concerning the living environment and presence of allergic diseases were performed on 1725 elementary school children living in Hirosaki-city and its suburbs in Aomiri Prefecture. In addition a scratch test for mite antigen was conducted 523 of the children and a patch test on 240. No difference was found between the rate of children diagnosed as having AD during the medical examination which was 12.9%, and the rate of children who responded as presently having AD in the questionnaire which was 12.8%. However the rate of concordance between those diagnosed to have AD by medical examination and the group that responded as having AD in the questionnaire was about 50%. For AD in children diagnosed by medical examination, a residential environment of the houses that there were moldy and leaking appeared to be a risk factor. Risk factors of children with AD from the questionnaire survey appeared to be houses built within 20 years. Clearly there were differences in conclusions regarding risk factor between the medical examination and the questionnaire. In terms of increasing reliability, a medical examination would be preferred. From the results of allergic tests, the children who lived in houses built within 20 years had a high response to the patch test. These results suggest that houses that are moldy and leaking, or built within 20 years may be considered to be risk factors for outbreak of AD.     

High resolution NMR spectroscopy using a recursive algorithm

When the DFT (discrete Fourier transform) is used as a method for obtaining NMR (nuclear magnetic resonance) spectrum, resolution of the obtained NMR spectrum depends clearly on spin-spin relaxation times of the nucleus and the sampled number of NMR signal. That is, the NMR spectrum is affected by decay of NMR signal due to the relaxation times and errors associated with discrete approximation of NMR spectrum. As a results, its resolution is degraded and the spectrum disagrees with the density distribution of the nucleus. In the present paper, we propose a new NMR spectrum estimation method for reducing their effects, demonstrating a high resolution NMR spectrum which is closer to the density distribution than that of the DFT. The proposed method is derived from applying the Kalman filter or the recursive least-square method to a NMR signal model based on Bloch equation. Under various conditions, the proposed method is compared with the DFT using a proton 1H NMR signal observed from mayonnaise in a 2 [T] static magnetic field. The results show that if spin-spin relaxation times are known previously, the proposed method can provide a higher resolution NMR spectrum than the DFT. In addition, it is shown that the method can reduce the discrete approximation errors of NMR spectrum. Finally, we demonstrate that if frequency components of sources of NMR signal are present in a limited range in frequency domain of interest, the method can magnify NMR spectrum with a sampling time and interval fixed.     

Prevention of carcinogenicity of anticancer drugs by metallothionein induction

We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of cis-platinum and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with cis-platinum or melphalan protected the mice from carcinogenesis of these drugs in the lung. These results suggested the efficacy of metallothionein inducers in suppression of carcinogenicity considered as a secondary effect of anticancer agents in cancer chemotherapy.