Col4a3-/- Mice on Balb/C Background Have Less Severe Cardiorespiratory Phenotype and SGLT2 Over-Expression Compared to 129x1/SvJ and C57Bl/6 Backgrounds

Alport syndrome (AS) is a hereditary renal disorder with no etiological therapy. In the preclinical Col4a3^-/- model of AS, disease progression and severity vary depending on mouse strain. The sodium-glucose cotransporter 2 (SGLT2) is emerging as an attractive therapeutic target in cardiac/renal pathologies, but its application to AS remains untested. This study investigates cardiorespiratory function and SGLT2 renal expression in Col4a3^-/- mice from three different genetic backgrounds, 129x1/SvJ, C57Bl/6 and Balb/C. male Col4a3^-/- 129x1/SvJ mice displayed alterations consistent with heart failure with preserved ejection fraction (HFpEF). Female, but not male, C57Bl/6 and Balb/C Col4a3^-/- mice exhibited mild changes in systolic and diastolic function of the heart by echocardiography. Male C57Bl/6 Col4a3^-/- mice presented systolic dysfunction by invasive hemodynamic analysis. All strains except Balb/C males demonstrated alterations in respiratory function. SGLT2 expression was significantly increased in AS compared to WT mice from all strains. However, cardiorespiratory abnormalities and SGLT2 over-expression were significantly less in AS Balb/C mice compared to the other two strains. Systolic blood pressure was significantly elevated only in mutant 129x1/SvJ mice. The results provide further evidence for strain-dependent cardiorespiratory and hypertensive phenotype variations in mouse AS models, corroborated by renal SGLT2 expression, and support ongoing initiatives to develop SGLT2 inhibitors for the treatment of AS.     

Stability preservation analysis in direct discretization of fractional order transfer functions

In this paper, a class of the direct methods for discretization of fractional order transfer functions is studied in the sense of stability preservation. The stability boundary curve is exactly determined for these discretization methods. Having this boundary helps us to recognize whether the original system and its discretized model are the same in the sense of stability. Finally, some illustrative examples are presented to evaluate achievements of the paper.     

Network‐coded multiple‐source cooperation aided relaying for free‐space optical transmission

A network‐coded cooperative relaying aided free‐space optical (FSO) transmission scheme is designed. The resultant multiple‐source cooperation diversity is exploited by the relay to mitigate the strong turbulence‐induced fading experienced in FSO channels. At the destination, an iterative multiple source detection algorithm is proposed in conjunction with a chip‐level soft network decoding method. Our performance evaluation results using simulation analysis demonstrate that the proposed FSO multiple source detection is capable of approaching the single‐user‐bound for transmission over Gamma–Gamma turbulence channels. Also, the network‐coded cooperative FSO scheme can achieve a significant BER improvement in comparison with conventional noncooperation schemes. Copyright © 2012 John Wiley & Sons, Ltd.     

An energy-aware distributed clustering protocol in wireless sensor networks using fuzzy logic

Clustering is an effective approach for organizing a network into a connected hierarchy, load balancing, and prolonging the network lifetime. On the other hand, fuzzy logic is capable of wisely blending different parameters. This paper proposes an energy-aware distributed dynamic clustering protocol (ECPF) which applies three techniques: (1) non-probabilistic cluster head (CH) elections, (2) fuzzy logic, and (3) on demand clustering. The remaining energy of the nodes is the primary parameter for electing tentative CHs via a non-probabilistic fashion. A non-probabilistic CH election is implemented by introducing a delay inversely proportional to the residual energy of each node. Therefore, tentative CHs are selected based on their remaining energy. In addition, fuzzy logic is employed to evaluate the fitness (cost) of a node in order to choose a final CH from the set of neighboring tentative CHs. On the other hand, every regular (non CH) node elects to connect to the CH with the least fuzzy cost in its neighborhood. Besides, in ECPF, CH elections are performed sporadically (in contrast to performing it every round). Simulation results demonstrate that our approach performs better than well known protocols (LEACH, HEED, and CHEF) in terms of extending network lifetime and saving energy.     

Prolong network lifetime and improve efficiency in WSN‐UAV systems using new clustering parameters and CSMA modification

Since unmanned aerial vehicles (UAVs) have been introduced as mobile nodes for data gathering, wireless sensor networks (WSNs) have progressed considerably. The resulting WSN‐UAV systems are employed for emergency applications and also for remote monitoring purposes. WSN‐UAV systems yield an optimum data gathering method using the WSN. In the proposed method, the nodes' data are transferred using a remotely operated vehicle (drone) rather than the conventional data transferring methods like the direct and hop‐to‐hop data transmission approaches. Then, the gathered data are delivered in the pre‐determined destination point. WSN‐UAV systems, in fact, are a special case of the systems with the mobile sink in which the sink path is previously specified and controlled. In this paper, the effects of clustering parameters on the WSNs are studied; then, the network's lifetime is prolonged by applying some parameters. In addition, the network's performance is enhanced to some extent by assigning some changes in the media access control (MAC) layer. Also, the effect of drone's path pattern on the lifetime of the network is studied.     

Design of efficient power amplifier for low power transmitters

This paper presents a fully integrated, low transmit-power and high-efficiency 2.4 GHz class-E power amplifier (PA) in TSMC 0.18 μm CMOS process for low-power transmitters such as wireless sensor networks (WSN). In this paper, a new output load has been proposed. Also, analytical design equations have been included to design an efficient low power circuit. This PA, employs the pad capacitance and bond-wire inductance of the output node, for satisfying class-E zero-voltage switching (ZVS) condition and matching the antenna’s 50 Ω resistance. By using bond-wire inductance instead of inductor in the output filter, smaller chip size and higher efficiency has been achieved compared to other works for low transmit-power applications. Also, the effectiveness of bulk-drive technique on faster switching and increasing efficiency have been evaluated. It has been proved that this technique leads to increase the efficiency of switching PAs. This PA delivers a range of output power from 2.7 to 7.2 dBm with a supply voltage range from 500 to 850 mV while achieving overall power efficiency range of 57.3–60.7%.