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ABSTRACT:  Several freshness and spoilage indicators were monitored to characterize the postmortem biochemistry of giant squid ( Dosidicus gigas ) mantle muscle. Squid samples were obtained directly from the sea and kept at 0 °C during a 15-d storage period. Data at zero time were obtained from cryogenically frozen samples at time of capture. The adenosine 5'-triphosphate (ATP) degradation followed a different pattern as compared with that from fish species. ATP was almost completely depleted at 24-h postcatch from 6.54 to <1 μmol/g, while at the same time Hx was the predominant catabolite with a concentration of 4 μmol/g, reaching 6.85 μmol/g at day 15. K -value data followed a logarithmic pattern with time instead of a linear one, with no change after day 3, thus reducing its suitability as a freshness index. The coefficient Hx/AMP seems to be an adequate alternative for this purpose due to its constant increment with time. The high NH4Cl content in mantle muscle (461.3 ± 24.5 mg of NH4+/100 g) derived from its physiological importance for the species compromises the use of the distillation step of the TVB-N analysis commonly used as a spoilage index. This fact explains why the initially high value of TVB-N detected in mantle muscle (243.7 mg N/100 g) did not correlate with the initial low TMA-N content (1.5 ± 0.1 mg/100 g of muscle). The results suggested that under the experimental conditions the shelf life of squid exceeds 15 d.  相似文献   
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The MT2-selective melatonin receptor ligand UCM765 (N-(2-((3-methoxyphenyl)(phenyl)amino)ethyl)acetamide), showed interesting sleep inducing, analgesic and anxiolytic properties in rodents, but suffers from low water solubility and modest metabolic stability. To overcome these limitations, different strategies were investigated, including modification of metabolically liable sites, introduction of hydrophilic substituents and design of more basic derivatives. Thermodynamic solubility, microsomal stability and lipophilicity of new compounds were experimentally evaluated, together with their MT1 and MT2 binding affinities. Introduction of a m-hydroxymethyl substituent on the phenyl ring of UCM765 and replacement of the replacement of the N,N-diphenyl-amino scaffold with a N-methyl-N-phenyl-amino one led to highly soluble compounds with good microsomal stability and receptor binding affinity. Docking studies into the receptor crystal structure provided a rationale for their binding affinity. Pharmacokinetic characterization in rats highlighted higher plasma concentrations for the N-methyl-N-phenyl-amino derivative, consistent with its improved microsomal stability and makes this compound worthy of consideration for further pharmacological investigation.  相似文献   
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NG Castle  V Mor 《Canadian Metallurgical Quarterly》1998,55(2):139-70; discussion 171-6
The use of physical restraints is one of the most negative features of nursing home care. Their use significantly affects the quality of life of residents. In an attempt to limit the use of restraints, the Nursing Home Reform Act (NHRA) of 1987 contained provisions regulating their use. In this article, the authors review the literature on the use and consequences of physical restraints in nursing homes since the passage of the NHRA. First, they describe the history behind the use of restraints and define what is considered to be a physical restraint. Second, they examine the four most common justifications for restraint use. Third, they describe the incidence and prevalence of restraint use. Fourth, they address demographic and clinical characteristics of residents that have been found to be associated with restraint use. Fifth, they examine negative outcomes of restraining residents. Finally, they describe alternatives to using restraints.  相似文献   
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In most cases, an extension of a polynomial time solution of a scheduling problem on a single machine to a proportionate flowshop leads to a similar (polynomial time) solution. One of the rare cases where the problem becomes hard, is that of maximizing the weighted number of Just-in-Time jobs on a proportionate flowshop. We introduce a (pseudo-polynomial) solution algorithm for this problem, which is faster by a factor of n than the algorithm published in the literature. We also introduce a (polynomial time) solution algorithm for the “no-wait” proportionate flowshop.  相似文献   
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CAMMInA: a mobile ambient information system to motivate elders to exercise   总被引:1,自引:1,他引:0  
Several strategies have been identified for designing effective persuasive technology that encourages people to adopt healthy lifestyle habits. However, to implement these strategies for motivating elders to exercise, we need to take into account the elders’ particular characteristics, their needs, and the problems they face to exercise. This paper presents the results of a case study conducted to identify the factors that influence elders to maintain a regular exercise routine. These results enabled us to inform the design of an ambient information system, which by requiring minimal attention and cognitive effort from elders, makes them aware of relevant information that motivates them to exercise. To reach this end, the system implements the following strategies for persuading: abstraction, historical information and reflection, triggers for exercising, and positive and playful reinforcement. A system usability evaluation enabled us to validate these strategies for motivating elders.  相似文献   
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