Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations

Brain stroke is a highly prevalent pathology and a main cause of disability among older adults. If not promptly treated with recanalization therapies, primary and secondary mechanisms of injury contribute to an increase in the lesion, enhancing neurological deficits. Targeting excitotoxicity and oxidative stress are very promising approaches, but only a few compounds have reached the clinic with relatively good positive outcomes. The exploration of novel targets might overcome the lack of clinical translation of previous efficient preclinical neuroprotective treatments. In this study, we examined the neuroprotective properties of 2-aminoethoxydiphenyl borate (2-APB), a molecule that interferes with intracellular calcium dynamics by the antagonization of several channels and receptors. In a permanent model of cerebral ischemia, we showed that 2-APB reduces the extent of the damage and preserves the functionality of the cortical territory, as evaluated by somatosensory evoked potentials (SSEPs). While in this permanent ischemia model, the neuroprotective effect exerted by the antioxidant scavenger cholesteronitrone F2 was associated with a reduction in reactive oxygen species (ROS) and better neuronal survival in the penumbra, 2-APB did not modify the inflammatory response or decrease the content of ROS and was mostly associated with a shortening of peri-infarct depolarizations, which translated into better cerebral blood perfusion in the penumbra. Our study highlights the potential of 2-APB to target spreading depolarization events and their associated inverse hemodynamic changes, which mainly contribute to extension of the area of lesion in cerebrovascular pathologies.     

Automatic verification of reduction techniques in Higher Order Logic

In this paper we propose an automatic methodology to verify the soundness of model checking reduction techniques. The idea is to use the consistency of the specifications to verify if the reduced model is faithful to the original one. The user provides the reduction technique, the specification and the system under verification. Then, using Higher Order Logic he verifies automatically if the reduction technique is soundly applied. The method is completely defined in an MDG–HOL special integration platform that combines an automatic high level model checking tool Multiway Decision Graphs (MDGs) within the HOL theorem prover. We provide two case studies, the first one is the reduction using SAT–MDG of an Island Tunnel Controller and the second one is the MDG–HOL assume-guarantee reduction of the Look-Aside Interface. The obtained results of our approach offer a considerable gain in terms of the correctness of heuristics and reduction techniques as applied to commercial model checking, however a small penalty is paid in terms of CPU time and memory usage.     

GPM: A generic and scalable P2P model that optimizes tree depth for multicast communications

Group communications (real‐time and non‐real‐time) refer to one‐to‐many or many‐to‐many communications. On the one hand, multicast is considered as an appropriate solution for supporting group communication‐oriented applications (we distinguish IP network multicast from application layer multicast). On the other hand, peer‐to‐peer model tends to be a good candidate for supporting today Internet applications (e.g. P2P IPTV, P2P VoIP, etc.). In this context, P2P has attracted significant interest in the recent years. This is mainly due to its properties that also make P2P well adapted to today social networks. In this paper, we propose GPM (Generic P2P Multicast): a novel generic and scalable approach, that optimizes multicast tree depth in P2P networks (structured and unstructured), and contributes to control the network overlay latency. For multicast tree construction, the approach we propose is based on a distributed algorithm using a specific data structures (adjacency and forwarding matrixes). GPM model inherits from P2P attributes such as scalability, flexibility and fault tolerance, while taking into consideration the respective characteristics of one‐to‐many and many‐to‐many type of applications. We also give a performance evaluation for validation and comparison purposes while considering some main existing application layer multicast protocols. Copyright © 2011 John Wiley & Sons, Ltd.     

A MC-CDMA Mobile Communication System Employing Pre-Rake and Transmit Diversity

In this paper, a multi-carrier code division multiple access (MC-CDMA) downlink mobile communication system employing pre-rake and dual transmit diversity is proposed. It combines high spectral efficiency with an immunity to channel dispersion and fading. It also ensures small size, cost and power consumption of the terminal. Theoretical and simulation results for the system under consideration are obtained. Depicted results show appreciable improvements of the proposed system over those previously known.Emad K. Al-Hussaini received his B.Sc degree in Electrical Communication Engineering from Ain-Shams University, Cairo, Egypt, in 1964 and his M.Sc and Ph.D. degrees from Cairo University, Giza, Egypt, in 1974 and 1977, respectively. From 1964 to 1970, he was with the General Egyptian Aeroorganization. Since 1970, he has been with the Department of Electronics and Communications, Faculty of Engineering, Cairo University, and is currently professor there. He was a research fellow at Imperial College, London, UK, and at the Moore School of Electrical Engineering, University of Pennsylvania, Philadelphia, PA, USA, in the academic years 1976/1977 and 1981/1982, respectively. In 1990, he received the Egyptian national encouragement award for outstanding engineering research. He has written several papers for technical international journals and conferences. His research interests include signal processing, fading channel communication, modulation, and cellular mobile radio systems. Dr Al-Hussaini is a senior member of IEEE. He is listed in Marquis Whos Who in the World and in the IBC (International Biographical Center, Cambridge) for outstanding people of the 20th century.Hebat-Allah M.Mourad received her B.Sc, M.Sc and Ph.D degrees in Electrical Communication Engineering from Cairo University, Egypt, in 1983, 1987 and 1994 respectively. Since 1983 she has been with the Electronics and Communications Department, Faculty of Engineering Cairo University and is currently associate professor there. Her research interests include mobile communications, satellite communications and optical fiber communications.Fatma A. Newagy received her B.Sc and M.Sc degrees in electrical communication engineering from Cairo University, Egypt in 1998 and 2002 respectively. Since 1999, she has been a research assistant with the Department of Electronics and Communications, Faculty of Engineering, Cairo University. She is pursuing her Ph.D. there. Her research interests include mobile communications and modulation techniques for spread spectrum and wireless communications.     

Fault diagnosis using partial syndromes: a modified Hopfield neural network approach

This paper presents a modified Hopfield neural network (HNN) for solving the system-level fault diagnosis problem which aims at identifying the set of faulty nodes. This problem has been extensively studied in the last three decades. Nevertheless, identifying the set of all faulty nodes using only partial syndromes, i.e. when some of the testing or comparison outcomes are missing prior to initiating the diagnosis phase, remains an outstanding research issue. The new HNN-based diagnosis algorithm does not require any prior learning or knowledge about the system, nor about any faulty situation, hence providing a better generalisation performance. Results from a thorough simulation study demonstrate the effectiveness of the HNN-based fault diagnosis algorithm in terms of diagnosis correctness, diagnosis latency and diagnosis scalability, for randomly generated diagnosable systems of different sizes and under various fault scenarios. We have also conducted extensive simulations using partial syndromes. Simulations showed that the HNN-based diagnosis performed efficiently, i.e. diagnosis correctness was around 99% when at most half of the test or comparison outcomes are missing, making it a viable alternative to existing diagnosis algorithms.     

Hierarchical steganography using novel optimum quantization technique

Security and imperceptibility are fundamental issues for steganography. This paper presents a multi-level steganography system based on concealing and deception. Basically, the secret image is embedded in a cover image, which in turn is embedded in another higher-level cover image. Each steganography level provides additional security, with lower levels implemented using stronger steganography methods. Furthermore, in the event that the higher level steganography is compromised, it would include misleading information to deceive the attacker that he/she is successfully eavesdropping. One challenge of hierarchical system is retaining hidden data in lower level in a higher level stenographic technique. To mitigate this issue, we designed a novel technique which combines discrete cosine transform and least significant bit (LSB). The technique objective is to maximize the capacity and invisibility of the secret image with minimal modification to the cover image (at most k-bits per block). The performance (capacity and peak signal-to-noise ratio) of the proposed method has superior performance compared with LSB since it combines the benefits of 1-bit and 3-bit LSBs. Furthermore, the paper demonstrates that the secret message is successfully embedded and extracted in two-level steganography system with peak signal-to-nose ratio greater than 20 dB.     

Rapid and efficient hand gestures recognizer based on classes discriminator wavelet networks

Multimedia Tools and Applications - The vision based on hand gesture recognition is one of the key challenges in behavior understanding and computer vision. It offers to machines the possibility of...     

Bioconversion of shrimp shell waste for the production of antioxidant and chitosan used as fruit juice clarifier

The pH, proteolytic activity, extent of demineralisation and deprotenisation of shrimp waste were studied during 7 days of fermentation using Pseudomonas aeruginosa A2. After 3 days, pH dropped from 7.0 to 4.4 and then remained constant. Simultaneously, a demineralisation of 92% was achieved. However, protease activity reached its highest level (1230 U mL^?1) after 1 day of incubation, and a protein removal of 90% was achieved. Chitin obtained was converted to chitosan. This chitosan, with 73% deacetylation, was tested for clarification of different fruit juices. It was observed that low concentrations of chitosan (below to 1%) greatly increase the clarity of juices without affecting the nutritional value. The antioxidant activity of the hydrolysates produced during fermentation was tested. Hydrolysate obtained after 3 days showed the strongest scavenging activity (90%), which was comparable to the positive control BHA; however, that obtained after 1 day exhibited the highest ferric‐reducing antioxidant power (OD 700 nm = 1.7).     

Characterization of boride coatings on a ductile cast iron

In this work, the EN-GJS-400-15 cast iron was pack-borided in a powder mixture composed of 5% B₄C, 5% NaBF₄ and 90% SiC at the three temperatures: 900, 950 and 1000°C for 2, 4 and 6 h, respectively. The pack-borided EN-GJS-400-15 cast iron was characterized by the following experimental techniques: optical microscopy, XRD analysis and Microhardness Vickers tester. The growth kinetics of boride layers was also investigated. As a consequence, the boron activation energy was found to be 212.28 kJ mol^–1 for the EN-GJS-400-15 cast iron. Based on a regression model, a useful equation was derived to estimate the boride layer thickness as a function of the boriding parameters (time and temperature). A good agreement was then obtained between the predicted values of boride layers thicknesses and those measured experimentally. In addition, an iso-thickness diagram was proposed to be used as a simple tool to select the boride layers thicknesses according to the potential applications of EN-GJS-400-15 cast iron in industry.