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51.
52.
Shanmugasundaram Sankar Muthusamy Nataraj 《The International Journal of Advanced Manufacturing Technology》2011,53(1-4):1-10
This work applies modular design concepts to designating beverage-container injection molds. This study aims to develop a method of controlling costs and time in relation to mold development, and also to improve product design. This investigation comprises two parts: functionality coding, and establishing a standard operation procedure, specifically designed for beverage-container injection mold design and manufacturing. First, the injection mold is divided into several modules, each with a specific function. Each module is further divided into several structural units possessing sub-function or sub-sub-function. Next, dimensions and specifications of each unit are standardized and a compatible interface is constructed linking relevant units. This work employs a cup-shaped beverage container to experimentally assess the performance of the modular design approach. The experimental results indicate that the modular design approach to manufacturing injection molds shortens development time by 36% and reduces costs by 19??23% compared with the conventional approach. Meanwhile, the information on modularity helps designers in diverse products design. Additionally, the functionality code helps effectively manage and maintain products and molds. 相似文献
53.
In this paper a modified version of Saleh-Valenzuela (S-V) channel model has been proposed for Ultra Wide Band (UWB) Orthogonal Frequency Division Multiplexing (OFDM) system and the performance has been estimated. In the proposed model, Poisson process has been modified for ray arrival rate and found that the proposed model is optimum for modeling ray arrival rate as compared to S-V model. Also Nakagami fading distribution has been considered in UWB channel model which suits for time varying multipath radio environment. The performance of the proposed channel model has been statistically analyzed over multiband OFDM by considering frequency domain channel estimation technique. The estimated coefficients have been tracked using Kalman filter technique and found that it gives more accurate prediction of channel coefficients as compared with Least Squares and Minimum Mean Square Estimation channel estimation techniques. 相似文献
54.
The present paper aims at measuring energy use efficiency in Indian cement industry and estimating the factors explaining
inter-firm variations in energy use efficiency. Within the framework of production theory, data envelopment analysis has been
used to measure energy use efficiency. Using firm-level data from electronic PROWESS database for the years 1989–1990 through
2006–2007, the study first estimates energy use efficiency of the firms and then compares the efficiency scores across. Empirical
results suggest that there is enough scope for the Indian cement firms to reduce energy uses, though this potential for energy
saving varies across firms. A second-stage regression analysis reveals that firms with larger production volume have higher
energy efficiency scores and that age of the firms impacts differently on energy use efficiency obtained from two different
models. Also, higher quality of labor force associates with higher energy use efficiency. 相似文献
55.
Venkateshwarapuram Rengaswami Giri Dev Jayarama Reddy Venugopal Muthusamy Senthilkumar Deepika Gupta Seeram Ramakrishna 《应用聚合物科学杂志》2009,113(5):3397-3404
Box Behnken design of experiment was used to study the effect of process variables such as alkali concentration, temperature and time on water retention capacity of the alkaline hydrolysed electrospun fibres. The hydrolysis of electrospun polyacrylonitrile fibres was carried out using sodium hydroxide with different processing conditions like concentration of alkali, temperature and time. With the increase in the concentration of alkali, time and temperature, the water retention capacity of membrane was found to increase in the membranes. Water retention capacities of the membranes were modeled and predicted using empirical as well as artificial neural network (ANN model). The fiber diameter and mean flow pore diameter of electrospun polyacrylonitrile fibers and hydrolyzed fibers shown in SEM images were 310 ± 50, 275 ± 75 nm, 0.9258 and 1.12 microns, respectively. The present study indicated that the nanofibrous membranes have potential for the water absorbing applications. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009 相似文献
56.
Veeramuthu Stalin Elanchezhian Muthusamy Kandaswamy 《Inorganic chemistry communications》2009,12(2):161-165
A multi-channel signaling cation sensor R had been achieved by covalently connecting ferrocene unit to the nitrogen (CN) containing binding site. Ferrocene-based sensor R was synthesized and characterized by spectroscopic methods and single crystal XRD. The chromogenic, flourogenic and electrochemical sensor study of R in CH3CN shows selective binding of Cu2+ ion. Inherently molecule R performs as molecular switch beyond the sensing role. 相似文献
57.
A new Schiff base functionalized dicyanate ester was synthesized and the monomer was characterized by FTIR, 1H-NMR, 13C-NMR and elemental analysis techniques. This prepared dicyanate ester with catalyst was then blended with BMI resin at different ratios by solution technique. The composites were made by impregnating the fibers with the blend solution followed by curing at various time-temperature schedules. The mechanical properties of the blend composites were tested. The fiber volume fraction of the composites were found to be in the range 41 ± 3%. The mechanical properties such as tensile modulus (32–35 GPa), flexural modulus (56–59 GPa) and Mode I fracture toughness (GIC = 104–136 J/m2) and impact response (1,121–1,218 J/m) were found to increase with increasing cyanate ester content in the Cy/BMI blends. From the DMA study it was observed that as the cyanate content increases from 3 to 9% in the blend the tan δ value increases from 0.112 to 0.126 and the storage modulus decreases from 24,750 to 22,870 MPa indicating that the crosslink density of the blends decreases. The SEM analysis shows the absence of phase separation. Moisture absorption and chemical resistance of the blend composites increase with increasing cyanate content. POLYM. COMPOS., 2009. © 2009 Society of Plastics Engineers 相似文献
58.
Hepatocyte‐Specific Delivery of siRNAs Conjugated to Novel Non‐nucleosidic Trivalent N‐Acetylgalactosamine Elicits Robust Gene Silencing in Vivo 下载免费PDF全文
Dr. Kallanthottathil G. Rajeev Dr. Jayaprakash K. Nair Dr. Muthusamy Jayaraman Dr. Klaus Charisse Nate Taneja Jonathan O'Shea Jennifer L. S. Willoughby Kristina Yucius Tuyen Nguyen Svetlana Shulga‐Morskaya Dr. Stuart Milstein Abigail Liebow Dr. William Querbes Dr. Anna Borodovsky Dr. Kevin Fitzgerald Dr. Martin A. Maier Dr. Muthiah Manoharan 《Chembiochem : a European journal of chemical biology》2015,16(6):903-908
We recently demonstrated that siRNAs conjugated to triantennary N‐acetylgalactosamine (GalNAc) induce robust RNAi‐mediated gene silencing in the liver, owing to uptake mediated by the asialoglycoprotein receptor (ASGPR). Novel monovalent GalNAc units, based on a non‐nucleosidic linker, were developed to yield simplified trivalent GalNAc‐conjugated oligonucleotides under solid‐phase synthesis conditions. Synthesis of oligonucleotide conjugates using monovalent GalNAc building blocks required fewer synthetic steps compared to the previously optimized triantennary GalNAc construct. The redesigned trivalent GalNAc ligand maintained optimal valency, spatial orientation, and distance between the sugar moieties for proper recognition by ASGPR. siRNA conjugates were synthesized by sequential covalent attachment of the trivalent GalNAc to the 3′‐end of the sense strand and resulted in a conjugate with in vitro and in vivo potency similar to that of the parent trivalent GalNAc conjugate design. 相似文献
59.
60.
Boopathi Muthusamy Sujatha Ramalingam Senthil Kumar Chandran Sathish Kumar Kannaiyan 《IET nanobiotechnology / IET》2021,15(2):173
Herein, multivariate Lagrange''s interpolation polynomial (MLIP) and multivariate least square (MLS) methods are used to derive linear and higher‐order polynomials for two varied applications. (1) For an effective fabrication of Pectin degrading Fe3O4‐SiO2 Nanobiocatalyst activity (IU/mg). Here, the three parameters namely: pH value, pectinase loading and temperature as independent variables are optimized for the maximal of anobiocatalyst activity as a dependent variable. (2) For a passive system reliability estimation of decay heat removal (DHR) of a nuclear power plant. The success criteria of the system depend on three types temperature that do not exceed their respective design safety limits and are considered as dependent variables and 14 significant parameters were used as independent variables. Statistically, the validation of these multivariate polynomials are done by testing of hypothesis. Comparative study of the proposed approach gives significance results in the first application have the optimum conditions for maximum activity using linear MLIP method is: 58.64 with pH = 4, pL = 250 and Temp = 4°C. The maximum activity using second order MLIP method is 59.825 and method of MLS is 59.8249 with the optimized values of an independent variables pH = 4, pL = 300 and Temp = 8°C depicted in Table 1. In DHR system, the significance results are obtained and depicted in Table 2. 相似文献