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51.
    
Multimedia Tools and Applications - Nowadays, due to widespread usage of the Internet, digital contents are distributed quickly and inexpensively throughout the world. Watermarking techniques can...  相似文献   
52.
    
The magnetic coupling of a set of SrFe12O19/CoFe2O4 nanocomposites is investigated. Advanced electron microscopy evidences the structural coherence and texture at the interfaces of the nanostructures. The fraction of the lower anisotropy phase (CoFe2O4) is tuned to assess the limits that define magnetically exchange-coupled interfaces by performing magnetic remanence, first-order reversal curves (FORCs), and relaxation measurements. By combining these magnetometry techniques and the structural and morphological information from X-ray diffraction, electron microscopy, and Mössbauer spectrometry, the exchange intergranular interaction is evidenced, and the critical thickness within which coupled interfaces have a uniform reversal unraveled.  相似文献   
53.
    
Phosphorodiamidate morpholino oligomers (PMOs) are oligonucleotide analogs that can be used for therapeutic modulation of pre‐mRNA splicing. Similar to other classes of nucleic acid‐based therapeutics, PMOs require delivery systems for efficient transport to the intracellular target sites. Here, artificial peptides based on the oligo(ethylenamino) acid succinyl‐tetraethylenpentamine (Stp), hydrophobic modifications, and an azide group are presented, which are used for strain‐promoted azide‐alkyne cycloaddition conjugation with splice‐switching PMOs. By systematically varying the lead structure and formulation, it is determined that the type of contained fatty acid and supramolecular assembly have a critical impact on the delivery efficacy. A compound containing linolenic acid with three cis double bonds exhibits the highest splice‐switching activity and significantly increases functional protein expression in pLuc/705 reporter cells in vitro and after local administration in vivo. Structural and mechanistic studies reveal that the lipopeptide PMO conjugates form nanoparticles, which accelerate cellular uptake and that the content of unsaturated fatty acids enhances endosomal escape. In an in vitro Duchenne muscular dystrophy exon skipping model using H2K‐mdx52 dystrophic skeletal myotubes, the highly potent PMO conjugates mediate significant splice‐switching at very low nanomolar concentrations. The presented aminoethylene‐lipopeptides are thus a promising platform for the generation of PMO‐therapeutics with a favorable activity/toxicity profile.  相似文献   
54.
    
Injectable composite pastes were prepared using melt-derived 45S5 bioactive glass and tragacanth crosslinked by (3-glycidyloxypropyl)trimethoxysilane (GPTMS). The effect of powder to liquid ratio (P:L = 1.0:2.0–1.0:2.5) and GPTMS/tragacanth ratio (0.0–1.5) on the injectability, swelling behavior, rheology, bioactivity, and cellular behavior of the pastes was investigated. Based on the results, the apparent stability and consistency of the pastes increased upon crosslinking by GPTMS. Due to the increased interactions between tragacanth and glass, a hysteresis loop with larger area was formed in the presence of GPTMS. With increase of GPTMS:tragacanth ratio from 0 to 1.5, the swelling percent dropped from 24.65 to 16.25% after 24 h and the degradation percent also went down from 27.89 to 9.11% after 21 days in the simulated body fluid. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed a drop in the optical density of MG63 osteoblasts up to 30.07% after exposure to the GPTMS-crosslinked composite pastes for 3 days. However, the number of viable cells gradually increased in the presence of the pastes and the cell morphology remained unchanged over time. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47604.  相似文献   
55.
    
The highly dynamic nature of the current network traffics makes the network managers to exploit the flexibility of the state‐of‐the‐art paradigm called SDN. In this way, there has been an increasing interest in hybrid networks of SDN‐MPLS. In this paper, a new traffic engineering architecture for SDN‐MPLS network is proposed. To this end, OpenFlow‐enabled switches are applied over the edge of the network to improve flow‐level management flexibility while MPLS routers are considered as the core of the network to make the scheme applicable for existing MPLS networks. The proposed scheme re‐assigns flows to the Label‐Switched Paths (LSPs) to highly utilize the network resources. In the cases that the flow‐level re‐routing is insufficient, the proposed scheme re‐computes and re‐creates the undergoing LSPs. To this end, we mathematically formulate two optimization problems, ie, i) flow re‐routing and ii) LSP re‐creation, and propose a heuristic algorithm to improve the performance of the scheme. Our experimental results show the efficiency of the proposed hybrid SDN‐MPLS architecture in traffic engineering superiors traditionally deployed MPLS networks.  相似文献   
56.
Rubber and fluid-filled rubber engine mounts are commonly used in automotive and aerospace applications to provide reduced cabin noise and vibration, and/or motion accommodations. In certain applications, the rubber mount may operate at frequencies as high as 5000 Hz. Therefore, dynamic stiffness of the mount needs to be known in this frequency range. Commercial high frequency test machines are practically nonexistent, and the best high frequency test machine on the market is only capable of frequencies as high as 1000 Hz. In this paper, a high frequency test machine is described that allows test engineers to study the high frequency performance of rubber mounts at frequencies up to 5000 Hz.  相似文献   
57.
The location-routing problem (LRP) is a relatively new research area within location analysis that concerns simultaneously both the problems of location of facilities and routing of vehicles among the established facilities and the demand points. In this work, we address the capacitated LRP with probabilistic travel times, which may arise in many practical contexts in logistics and supply chain management, and present some bi-objective mathematical programming formulations to model the problem using different stochastic programming approaches. The first objective is to minimize the overall system-wide costs, while the second objective concerns minimization of the maximum delivery time to the customers. In all the cases, the deterministic equivalents of the stochastic models have been extracted. To solve the resulted models, a variable neighborhood descent-based heuristic is proposed and finally computational study is performed and numerical results are reported.  相似文献   
58.
Tungsten and aluminum elemental powders with composition W–20 wt.% Al were mechanical alloyed in high energy planetary ball mill. Structural and morphological changes of powder particles after different milling times were studied by X-ray diffractometer, scanning electron microscopy and microhardness measurements. Mechanical alloying of this system led to the formation of W–Al alloy as a result of formation of W/Al layered microstructure having faceted interface between layers. This alloy indicated high microhardness value of about 570 Hv.  相似文献   
59.
60.
It is generally known that the contact between tube and die, in the case of tube hydroforming process, leads to the appearance of friction effects. In this context, there are many different models for representing friction and many different tests to evaluate it. In the present paper, the pin-on-disk test has been used and the theoretical model of Orban-2007 has been chosen and developed to evaluate friction coefficient. The main goal is to prove the capacity of theoretical model to present the friction conditions in comparison with the pin-on-disk test. From the Orban model, values of 0.05 and 0.25 of friction coefficient have been found under lubricated and dry tests, respectively. On the other hand, by the classical pin-on-disk test, other values were experimentally obtained as friction coefficient at the copper/steel interface. In the case of pure expansion hydroforming, based on an internal pressure loading only, a “corner filling” test has been run for tube hydroforming. Both dry and lubricated contacts have been considered. Various configurations and shapes have been studied such as the rectangular, trapezoidal, and trapezoid-sectional dies. Finite element simulations with 3D shell and 3D solid models have been performed with different values of friction coefficients. From the main results, it was found that the critical thinning occurs in the transition zone for the square and rectangular section die and in the sharp angle for the trapezoidal and trapezoid-sectional die. The comparison between numerical data and experimental results shows a good agreement. Moreover, the thickness distribution along the cross section is relatively consistent with those measured for the 3D shell model; however, the 3D solid models do not provide a realistic representation of the thickness distribution in the shaped tube. Finally, the results obtained from the theoretical model were more efficient than the results obtained from the pin-on-disk test.  相似文献   
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