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101.
In this paper, we introduce a two‐layered approach addressing the problem of creating believable mesh‐based skin deformation. For each frame, the skin is first deformed with a classic linear blend skinning approach, which usually leads to unsightly artefacts such as the well‐known candy‐wrapper effect and volume loss. Then we enforce some geometric constraints which displace the positions of the vertices to mimic the behaviour of the skin and achieve effects like volume preservation and jiggling. We allow the artist to control the amount of jiggling and the area of the skin affected by it. The geometric constraints are solved using a position‐based dynamics (PBDs) schema. We employ a graph colouring algorithm for parallelizing the computation of the constraints. Being based on PBDs guarantees efficiency and real‐time performances while enduring robustness and unconditional stability. We demonstrate the visual quality and the performance of our approach with a variety of skeleton‐driven soft body characters. 相似文献
102.
The Oral Bioavailability of Trans‐Resveratrol from a Grapevine‐Shoot Extract in Healthy Humans is Significantly Increased by Micellar Solubilization 下载免费PDF全文
103.
Zheng Wang Pascal Fongarland Guanzhong Lu Wangcheng Zhan Nadine Essayem 《中国稀土学报(英文版)》2018,36(4):359-366
Magnesium and rare earth mixed oxides (Mg3REOx (RE = La, Y, Ce)) were prepared and characterized by X-ray diffraction (XRD), N2 adsorption–desorption, infrared spectra and microcalorimetry of CO2. The results reveal that the Mg3CeOx catalyst is present in the form of Mg-Ce-O solid solution, while the Mg3LaOx and Mg3YOx catalysts are probably rare earth oxides dispersed on MgO surface. As a result, among the calcined Mg3REOx catalysts, the Mg3CeOx catalyst presents the highest rate constant for acetone aldolization, which is well correlated to its more homogeneous distribution of basic sites. In contrary, the Mg3YOx catalyst exhibit the lowest catalytic activity for acetone aldolization. Upon hydration pre-treatment, the basic properties on the surface of the Mg3REOx catalysts were changed markedly. The Mg3YOx catalyst after hydration treatment shows the highest amount of basic sites on catalyst surface, and then exhibits the highest activity among the hydrated Mg3REOx catalysts. These results make it possible to fine-tune basic sites for acetone aldolization. 相似文献
104.
105.
In the search for estrogen receptor (ER) modulators, a series of prenylflavonoids were found to be widely distributed amongst tonic herbal medicines and to possess estrogen-like activity in MCF-7/BOS cells, as evaluated by an estrogen-screening assay. Cell-cycle analysis revealed that the stimulatory effects of these compounds toward cell proliferation were elicited at the G1-S checkpoint and could significantly increase the S-phase population of MCF-7 cells under hormone-free conditions. ER-responsive gene (PS2, PgR) and protein (PgR) expression was also detected; mRNA and protein-expression levels for PS2 and PgR were up-regulated by the compounds in a dose-dependent manner. These effects could be inhibited by the pure ER antagonist ICI 182,780 ((7alpha-[9-{4,4,5,5,5-pentafluoropentyl}sulfinyl]nonyl)estra-1,3,5(10)-triene-3,17beta-diol). It was therefore concluded that the estrogen-like effects of these prenylflavonoids were mediated primarily through ERs. Furthermore, to explore the structure-activity relationship based on the estrogen receptor and detailed molecular mechanisms among the prenylflavonoids, protein-ligand docking simulations were carried out by using the DS-MODELING software package. The binding affinity of each prenylflavonoid toward ERalpha was scored, and the receptor-ligand interaction was also analyzed to provide the simulation characteristics of virtual molecular recognition mechanisms. 相似文献
106.
The predominant role of collagen in the nucleation, growth, structure and orientation of bone apatite 总被引:1,自引:0,他引:1
Wang Y Azaïs T Robin M Vallée A Catania C Legriel P Pehau-Arnaudet G Babonneau F Giraud-Guille MM Nassif N 《Nature materials》2012,11(8):724-733
The involvement of collagen in bone biomineralization is commonly admitted, yet its role remains unclear. Here we show that type I collagen in?vitro can initiate and orientate the growth of carbonated apatite mineral in the absence of any other vertebrate extracellular matrix molecules of calcifying tissues. We also show that the collagen matrix influences the structural characteristics on the atomic scale, and controls the size and the three-dimensional distribution of apatite at larger length scales. These results call into question recent consensus in the literature on the need for Ca-rich non-collagenous proteins for collagen mineralization to occur in vivo. Our model is based on a collagen/apatite self-assembly process that combines the ability to mimic the in vivo extracellular fluid with three major features inherent to living bone tissue, that is, high fibrillar density, monodispersed fibrils and long-range hierarchical organization. 相似文献
107.
108.
Fish protein increases circulating levels of trimethylamine‐N‐oxide and accelerates aortic lesion formation in apoE null mice 下载免费PDF全文
109.
Ceri A. Williams Paulina Unifantowicz Nadine Baluc George D.W. Smith Emmanuelle A. Marquis 《Acta Materialia》2013,61(6):2219-2235
The fabrication of oxide-dispersion-strengthened (ODS) steels is a multi-stage process involving powder ball milling, degassing and consolidation by hot isostatic pressing. Y is introduced by mechanical alloying (MA) with either Y2O3 or Fe2Y so a high density of Y–Ti–O-based oxide nanoparticles is formed. The evolution of ~2 nm oxide nanoparticles and larger >5 nm grain boundary oxides has been studied at each step of the processing. The nanoparticle dispersions produced in material MA with Fe2Y were comparable to those produced by alloying with Y2O3. Hence the majority of oxygen which forms the nanoparticles must be incorporated from the atmosphere during MA, rather than being introduced via the alloying additions. During mechanical alloying, a high density of subnanometer particles are formed (2.5 ± 0.5 × 1024 m?3). The oxygen content of the nanoparticles decreases slightly on annealing, and then the composition of the nanoparticles remains constant throughout subsequent processing stages. The nanoparticle size increases during processing up to ~2 nm radius, while the number density decreases to 4 ± 0.5 × 1023 m?3. Grain boundary oxides (>5 nm) have a Ti–Cr–O-rich shell, and contain no Y before consolidation, but have similar core composition to the matrix nanoparticles after consolidation. The formation of the larger grain boundary oxides is shown to take place during the degassing and consolidation stages, and this occurs at the expense of the nanoparticles in the matrix. This work provides a mechanistic understanding of the importance of controlling the oxygen content in the powder during MA, and the resulting impact on the formation of the ODS microstructure. 相似文献
110.
In times of globalisation and international trade, the concept of total quality management (TQM) as a strategy to enhance organisational performance is growing in importance. To exploit the benefits provided by TQM, organisations must manage the complex implementation process successfully. Therefore, organisations need to measure critical success factors (CSFs) when introducing TQM. However, previous research has developed a plethora of measurement instruments and researchers do not agree on certain factors or on one single measurement instrument. A systematic literature review is conducted to structure and clarify the scattered research field. The analysis of 145 studies reveals that CSFs can be classified into 11 distinct dimensions. The article proposes a three-level framework and a holistic set of measurement instruments to help researchers and managers measure each critical dimension in a timely and comprehensive manner. A focus group consisting of six quality managers validated these results. The study concludes with further findings and future research. Deficiencies of current measurements are presented and the article discusses the finding that human related factors are regarded as highly relevant but have remained low on many researchers’ and practitioners’ agendas. Hence, this article is a major contribution to structure the complex research field of measuring CSFs of TQM implementation. 相似文献