Simple laser velocimeter that uses photoconductive semiconductors to measure optical frequency differences

The dc photocurrents generated by steady-state moving space-charge fields inside photoconductive semiconductors containing deep level donors and traps can be used to determine the relative frequency differences between the two interfering optical fields that establish the space-charge fields. A simple laser velocimeter that uses a semi-insulating GaAs:Cr sample to detect the Doppler frequency shift between two laser beams is demonstrated.     

Large-scale mapping of boreal forest in SIBERIA using ERS tandem coherence and JERS backscatter data

Siberia's boreal forests represent an economically and ecologically precious resource, a significant part of which is not monitored on a regular basis. Synthetic aperture radars (SARs), with their sensitivity to forest biomass, offer mapping capabilities that could provide valuable up-to-date information, for example about fire damage or logging activity. The European Commission SIBERIA project had the aim of mapping an area of approximately 1 million km² in Siberia using SAR data from two satellite sources: the tandem mission of the European Remote Sensing Satellites ERS-1/2 and the Japanese Earth Resource Satellite JERS-1. Mosaics of ERS tandem interferometric coherence and JERS backscattering coefficient show the wealth of information contained in these data but they also show large differences in radar response between neighbouring images. To create one homogeneous forest map, adaptive methods which are able to account for brightness changes due to environmental effects were required. In this paper an adaptive empirical model to determine growing stock volume classes using the ERS tandem coherence and the JERS backscatter data is described. For growing stock volume classes up to 80 m³/ha, accuracies of over 80% are achieved for over a hundred ERS frames at a spatial resolution of 50 m.     

Characterizing distributed shared memory performance: a case studyof the Convex SPP1000

In a distributed shared memory (DSM) multiprocessor, the processors cooperate in solving a parallel application by accessing the shared memory. The latency of a memory access depends on several factors, including the distance to the nearest valid data copy, data sharing conditions, and traffic of other processors. To provide a better understanding of DSM performance and to support application tuning and compiler development for DSM systems, this paper extends microbenchmarking techniques to characterize the important aspects of a DSM system. We present an experiment-based methodology for characterizing the memory, communication, scheduling, and synchronization performance, and apply it to the Convex SPP1000. We present carefully designed microbenchmarks to characterize the performance of the local and remote memory, producer-consumer communication involving two or more processors, and the effects on performance when multiple processors contend for utilization of the distributed memory and the interconnection network     

A practical look at ATPG

Book Reviewed: Digital Logic Testing and Simulation, 2nd edition, by Alexander Miczo (Wiley-Interscience, 2003, ISBN 0-471-43995-9, 696 pp., $115).     

A bi-labeling based XPath processing system

We present BLAS, a Bi-LAbeling based XPath processing System. BLAS uses two labeling schemes to speed up query processing: P-labeling for processing consecutive child (or parent) axis traversals, and D-labeling for processing descendant (or ancestor) axis traversals. XML data are stored in labeled form and indexed. Algorithms are presented for translating XPath queries to SQL expressions. BLAS reduces the number of joins in the SQL query translated from a given XPath query and reduces the number of disk accesses required to execute the SQL query compared with the traditional XPath processing using D-labeling alone. We also propose an approximate P-labeling scheme and the corresponding query translation algorithm to handle XML data trees that contain a large number of distinct tag names, and/or are very deep. This extension captures a spectrum of XPath-to-SQL query translation schemes, ranging from existing schemes that do not use P-labels to the one that uses exact P-labels. Experimental results demonstrate the efficiency of the BLAS system.     

Effects of molecular crowding on the interaction between DNA and the Escherichia coli regulatory protein TyrR

Fluorescence quenching has been used to measure quantitatively the effects of sucrose and triethylene glycol on the interaction between the Escherichia coli regulatory protein TyrR and a 30-basepair oligonucleotide containing the strong TyrR box of the TyrR operon. It was observed that the apparent binding constant increased in the presence of co-solutes, the dependence of the logarithm of the apparent binding constant on molar concentration being indistinguishable and essentially linear for both co-solutes. This activation of the TyrR-oligonucleotide interaction is attributed to thermodynamic nonideality arising from molecular crowding, an interpretation which is supported by the reasonable agreement observed between the experimental extent of reaction enhancement and that predicted on the statistical-mechanical basis of excluded volume.     

Hyaluronan Synthase and Hyaluronidase Expression in Serous Ovarian Carcinoma is Related to Anatomic Site and Chemotherapy Exposure

The present study investigated the expression and clinical role of hyaluronan synthases (HAS1-3) and hyaluronidases (Hyal1-3) in serous ovarian carcinoma. HAS and HYAL mRNA expression was analyzed in 97 tumors (61 effusions, 27 primary carcinomas, 9 solid metastases) using PCR and further studied for association with clinicopathologic parameters, including survival. HAS1 mRNA was overexpressed in effusions compared to primary carcinomas and solid metastases (p < 0.001), and an alternatively spliced HAS1 was expressed only in effusions. HAS2 mRNA was overexpressed in solid metastases and primary carcinomas compared to effusions (p = 0.043), and HAS3 mRNA was overexpressed in primary carcinomas and effusions compared to solid metastases (p = 0.008). HYAL1 mRNA was absent in all specimens, whereas HYAL2 was expressed as two splice variants, of which HYAL2-var2 was overexpressed in solid metastases compared to effusions and primary carcinomas (p < 0.001). HYAL3 mRNA was expressed as wild-type and variant 1–3 form, the latter more highly in primary carcinomas and effusions compared to solid metastases (p = 0.006). HAS1 mRNA was overexpressed in pre- compared to post-chemotherapy effusions (p < 0.001), with opposite finding for HYAL2-var1 and HYAL3-WT (p = 0.016 and p = 0.024, respectively). Higher HYAL2-var1 and HAS1 splice variant mRNA expression in effusions was associated with longer (p = 0.033) and shorter (p = 0.047) overall survival, respectively. These data are the first to document a role for HAS and Hyal members in tumor progression in ovarian carcinoma, as evidenced by their differential expression as function of anatomic site and chemotherapy exposure, with a possible prognostic role for patients with malignant effusions.