Innovation in power semiconductor industry: past and future

Power microelectronics plays an important role in many of the consumer and industrial applications today. With increase in demand for energy savings and efficient systems, the requirements for rapid advancement in MOS controlled power semiconductor device concepts and technologies are becoming more crucial than ever before. This puts a considerable pressure on industries to be innovative and competitive at the device, technology, manufacturing, and marketing levels. Today manufacturing companies are faced with intensifying competition and a turbulent economic environment. To some extent technology is seen as a means by which firms can strive to adapt to the requirements of this difficult and uncertain environment. On the other hand, rapid rates of technological change and associated shorter product cycles are themselves part of the difficulty, as is the increased blurring of long-established industrial boundaries (Kodama's, 1985) process of "technological fusion". The growing complexity and increased pace of industrial technological change especially in power microelectronics are forcing firms to forge new alliances and to seek greater flexibility and efficiency in responding to market changes. The aim of this paper is to explore these aspects.     

An Overview of Next-Generation Androgen Receptor-Targeted Therapeutics in Development for the Treatment of Prostate Cancer

Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of the androgen receptor (AR) signaling axis since Huggins et al. discovered that diethylstilbestrol (DES; an estrogen) produced chemical castration and PCa tumor regression. Androgen deprivation therapy (ADT) still remains the first-line PCa therapy. Insufficiency of ADT over time leads to castration-resistant PCa (CRPC) in which the AR axis is still active, despite castrate levels of circulating androgens. Despite the approval and use of multiple generations of competitive AR antagonists (antiandrogens), antiandrogen resistance emerges rapidly in CRPC due to several mechanisms, mostly converging in the AR axis. Recent evidence from multiple groups have defined noncompetitive or noncanonical direct binding sites on AR that can be targeted to inhibit the AR axis. This review discusses new developments in the PCa treatment paradigm that includes the next-generation molecules to noncanonical sites, proteolysis targeting chimera (PROTAC), or noncanonical N-terminal domain (NTD)-binding of selective AR degraders (SARDs). A few lead compounds targeting each of these novel noncanonical sites or with SARD activity are discussed. Many of these ligands are still in preclinical development, and a few early clinical leads have emerged, but successful late-stage clinical data are still lacking. The breadth and diversity of targets provide hope that optimized noncanonical inhibitors and/or SARDs will be able to overcome antiandrogen-resistant CRPC.     

Prediction of Springback in Straight Flanging using Finite Element Method

One of the important features of flanging process is elastic recovery during unloading leading to springback. The elastic recovery is associated with various tool and material parameters. It is difficult to analytically predict the elastic recovery accurately owing to the complex material deformation behavior. In this investigation, a commercially available Finite Element software is used for elasto-plastic analysis of flanging process. The springback is studied varying geometrical, material and friction parameters. The results of the simulation are validated with a few published experimental results.     

Amperometric determination of hydrogen peroxide by functionalized carbon nanotubes through EDC/NHS coupling chemistry

The electrochemistry of the redox mediator Toluidine blue (TB) which was covalently linked to the carboxyl group of the multiwalled carbon nanotubes (MWNTs) by coupling reactions, in which N-hydroxysuccinimide was used to assist 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride catalyzed amidation reaction is described. The results from cyclic voltammetry (CV) and amperometry suggested that the redox mediator is linked to the surface of the MWNTs and the nanotubes showed an obvious promotion for the direct electron-transfer between the redox mediator and the electrode. A couple of well-defined redox peak of TB was observed in a phosphate buffer solution (pH 7.0). The redox mediator immobilized to MWNTs exhibits remarkable electrocatalytic activity for the reduction of hydrogen peroxide (H2O2). The analytical applicability of the modified electrode for the determination of hydrogen peroxide was examined. A linear response in the concentration range of 6.8 x 10(-7)-3.4 x 10(-2) M (r = 0.9958) was obtained with detection limit of 3.4 x 10(-7) M for the determination of hydrogen peroxide. The modified electrode has advantages of being highly stable, sensitive, ease of construction and use.     

Optimal Sensor Networks for Area Monitoring Using Rotating and Beam Sensors

We consider the problem of monitoring the Euclidean plane using rotating sensors with detection sectors and beam sensors. We assume that intruders can appear anywhere at any time and move arbitrarily fast, and may have full knowledge of the sensor network. We require that such intruders be detected within a finite amount of time. We give an optimal network for this problem consisting of a combination of rotating sensors of angle 0 and beam sensors that uses the minimum number of both types of sensors. We show a trade-off between the density of beam sensors needed and the angle of the detection sector of the rotating sensors. Secondly, we give a family of sensor networks using only rotating sensors for the same problem, that demonstrate a trade-off between the detection time and the density of rotating sensors used. We show that the density of rotating sensors required in this case can be significantly reduced by increasing the angle of detection sectors. Finally, we show that our results on the infinite plane can be used to derive sensor networks that monitor some finite regions using a density of sensors that is asymptotically the same, or close to that of the infinite plane case.     

Synthesis of High Coercivity Core–Shell Nanorods Based on Nickel and Cobalt and Their Magnetic Properties

Hybrid magnetic nanostructures with high coercivity have immense application potential in various fields. Nickel (Ni) electrodeposited inside Cobalt (Co) nanotubes (a new system named Ni @ Co nanorods) were fabricated using a two-step potentiostatic electrodeposition method. Ni @ Co nanorods were crystalline, and they have an average diameter of 150 nm and length of ~15 μm. The X-ray diffraction studies revealed the existence of two separate phases corresponding to Ni and Co. Ni @ Co nanorods exhibited a very high longitudinal coercivity. The general mobility-assisted growth mechanism proposed for the growth of one-dimensional nanostructures inside nano porous alumina during potentiostatic electrodeposition is found to be valid in this case too.     

Leaching of residues of certain pesticides from black tea to brew

Tea is the most commonly consumed beverage in the world. It is prepared after infusing processed black tea in hot water. During the process of brewing, along with flavour and aroma, the residues of plant protection chemicals may also be transferred into the tea brew or infusion. The leaching of certain pesticides, such as ethion, endosulfan, dicofol, chlorpyrifos, deltamethrin, hexaconazole, fenpropathrin, propargite, quinalphos and lambdacyhalothrin from powdered black tea into the brew was studied. The rate of transfer of the pesticide residue from black tea to the hot brew was largely influenced by physicochemical parameters, such as water solubility and octanol-water partition coefficient. Tea brews prepared from untreated black tea samples were fortified with standard solutions of the respective pesticides, extracted and analysed using GC and HPLC by following standardised methods. Results revealed that the rate of leaching of residues of these pesticides into the tea brew was low due to their low solubilities in aqueous medium and high octanol-water partitioning coefficients.     

Multi response optimization of wire EDM operations using robust design of experiments

In this present study a multi response optimization method using Taguchi’s robust design approach is proposed for wire electrical discharge machining (WEDM) operations. Experimentation was planned as per Taguchi’s L16 orthogonal array. Each experiment has been performed under different cutting conditions of pulse on time, wire tension, delay time, wire feed speed, and ignition current intensity. Three responses namely material removal rate, surface roughness, and wire wear ratio have been considered for each experiment. The machining parameters are optimized with the multi response characteristics of the material removal rate, surface roughness, and wire wear ratio. Multi response S/N (MRSN) ratio was applied to measure the performance characteristics deviating from the actual value. Analysis of variance (ANOVA) is employed to identify the level of importance of the machining parameters on the multiple performance characteristics considered. Finally experimental confirmation was carried out to identify the effectiveness of this proposed method. A good improvement was obtained.