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31.
32.
Gerhart Eigenberger 《Chemical engineering science》1978,33(9):1255-1261
The question under which conditions kinetic instabilities can be described by Langmuir type kinetics is studied using a fairly general model for the surface reactionpA + qB → C. This paper is concerned with the occurrence of rate multiplicities (ignition-extinction phenomena). It is shown that rate multiplicity can be caused by the competing chemisorption of A and B upon the same active sites of the catalyst. Rate multiplicity can occur if at least one of the chemisorption or reaction steps is of second order. No rate multiplicity can be expected, if either A or B reacts via an Eley-Rideal type mechanism. 相似文献
33.
Experimentally manipulated the conditions of beverage content and expectancy for alcohol in 29 heavy social-drinking (as determined by the Drinking Practices Questionnaire) male undergraduates. After completing a pencil-and-paper task, Ss found themselves in a situation where graffiti could apparently be written in and around the immediate surroundings with impunity. Regardless of expectations, Ss who actually drank alcohol were significantly more likely to write graffiti in this situation than were Ss who did not drink alcohol. This finding supports the importance of alcohol rather than expectancy as a causal influence on this form of disinhibited behavior. (12 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
34.
James CD Spence AJ Dowell-Mesfin NM Hussain RJ Smith KL Craighead HG Isaacson MS Shain W Turner JN 《IEEE transactions on bio-medical engineering》2004,51(9):1640-1648
Neuronal cell networks have been reconstructed on planar microelectrode arrays (MEAs) from dissociated hippocampal pyramidal neurons. Microcontact printing (microCP) and a photoresist-liftoff method were used to selectively localize poly-L-lysine (PLL) on the surface of MEAs. Haptotaxis led to the organization of the neurons into networks localized adjacent to microelectrodes. Various grids of PLL with 2-25-microm-wide lines spaced by 50-200 microm with 15-25-microm nodes at intersection points were used to guide cell body attachment and neurite outgrowth. Bursting activity with spike amplitude attenuation was observed, and multichannel recordings detected instances of coincident firing activity. Finally, we present here an extracellular recording from a approximately 2 microm bundle of guided neurites. 相似文献
35.
Short-term exposures to chronically toxic copper concentrations induce HSP70 proteins in midge larvae (Chironomus tentans) 总被引:1,自引:0,他引:1
In the present study, we investigated the induction of HSP70 proteins in Chironomus tentans in response to copper exposure. Larvae were exposed for 24 h to 0, 0.25, 0.5, 1.0 and 2.0 mgl(-1) copper, concentrations that were previously shown to cause growth reduction or mortality in 10 d bioassays. The induction of HSP70 was evaluated by Western blotting, and we observed a significant increase in HSP70 proteins over controls at all tested concentrations. The results suggest that short-term laboratory exposures to chronically toxic but acutely sublethal copper concentrations induce HSP70 proteins in C. tentans larvae. 相似文献
36.
Machado Liana; Wyatt Natalie; Devine Amy; Knight Benjamin 《Canadian Metallurgical Quarterly》2007,33(5):1045
Humans have a remarkable capability to respond efficiently to a stimulus of interest despite other stimuli competing for neural resources. The current study investigated how the human system copes with distracting stimuli. During each trial, participants viewed 2 sequential stimuli that were each associated with a specific action based on an arbitrary mapping. The 1st stimulus served as a distractor, and the 2nd stimulus required a response (target). When the distractor preceded the target by more than a few hundred milliseconds, response latencies were slower when the 2 stimuli were associated with the same response. The authors propose that this negative compatibility effect stemmed from an inhibitory mechanism that the human system utilizes to prevent the distractor from eliciting an unwanted response. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
37.
Built of sand – tension from unsaturation enable unimaginable sculptures. Partly saturated sand enables to form astonishing figures and sculptures of sand. Curvers are forming sculptures, which are presented in open air exhibitions. It can be shown, that suction caused by waterfilms in the pores of the soil is the physical reason for the tension stress of unsaturated soils. 相似文献
38.
Stefan Bachevillier Hua‐Kang Yuan Andrew Strang Artem Levitsky Gitti L. Frey Andreas Hafner Donal D. C. Bradley Paul N. Stavrinou Natalie Stingelin 《Advanced functional materials》2019,29(21)
Managing the interference effects from thin (multi‐)layers allows for the control of the optical transmittance/reflectance of widely used and technologically significant structures such as antireflection coatings (ARCs) and distributed Bragg reflectors (DBRs). These rely on the destructive/constructive interference between incident, reflected, and transmitted radiation. While known for over a century and having been extremely well investigated, the emergence of printable and large‐area electronics brings a new emphasis: the development of materials capable of transferring well‐established ideas to a solution‐based production. Here, demonstrated is the solution‐fabrication of ARCs and DBRs utilizing alternating layers of commodity plastics and recently developed organic/inorganic hybrid materials comprised of poly(vinyl alcohol) (PVAl), cross‐linked with titanium oxide hydrates. Dip‐coated ARCs exhibit an 88% reduction in reflectance across the visible compared to uncoated glass, and fully solution‐coated DBRs provide a reflection of >99% across a 100 nm spectral band in the visible region. Detailed comparisons with transfermatrix methods (TMM) highlight their excellent optical quality including extremely low optical losses. Beneficially, when exposed to elevated temperatures, the hybrid material can display a notable, reproducible, and irreversible change in refractive index and film thickness while maintaining excellent optical performance allowing postdeposition tuning, e.g., for thermo‐responsive applications, including security features and product‐storage environment monitoring. 相似文献
39.
Daniel J. O’Shannessy Stephen M. Jackson Natalie C. Twine Bryan E. Hoffman Zoltan Dezso Sergei I. Agoulnik Elizabeth B. Somers 《International journal of molecular sciences》2013,14(7):13687-13703
Folate receptor alpha (FOLR1/FRA) is reported to be overexpressed in epithelial ovarian cancers (EOC), especially the serous histotype. Further, while dysregulation of the folate-dependent 1-carbon cycle has been implicated in tumorogenesis, little is known relative to the potential mechanism of action of FOLR1 expression in these processes. We therefore investigated the expression of FOLR1, other folate receptors, and genes within the 1-carbon cycle in samples of EOC, normal ovary and fallopian tube on a custom TaqMan Low Density Array. Also included on this array were known markers of EOC such as MSLN, MUC16 and HE4. While few differences were observed in the expression profiles of genes in the 1-carbon cycle, genes previously considered to be overexpressed in EOC (e.g., FOLR1, MSLN, MUC16 and HE4) showed significantly increased expression when comparing EOC to normal ovary. However, when the comparator was changed to normal fallopian tube, these differences were abolished, supporting the hypothesis that EOC derives from fallopian fimbriae and, further, that markers previously considered to be upregulated or overexpressed in EOC are most likely not of ovarian origin, but fallopian in derivation. Our findings therefore support the hypothesis that the cell of origin of EOC is tubal epithelium. 相似文献
40.
Elizabeth E. Ellis Dr. Chinessa T. Adkins Natalie M. Galovska Dr. Luke D. Lavis Dr. R. Jeremy Johnson 《Chembiochem : a European journal of chemical biology》2013,14(9):1134-1144
Serine hydrolases have diverse intracellular substrates, biological functions, and structural plasticity, and are thus important for biocatalyst design. Amongst serine hydrolases, the recently described ybfF enzyme family are promising novel biocatalysts with an unusual bifurcated substrate‐binding cleft and the ability to recognize commercially relevant substrates. We characterized in detail the substrate selectivity of a novel ybfF enzyme from Vibrio cholerae (Vc‐ybfF) by using a 21‐member library of fluorogenic ester substrates. We assigned the roles of the two substrate‐binding clefts in controlling the substrate selectivity and folded stability of Vc‐ybfF by comprehensive substitution analysis. The overall substrate preference of Vc‐ybfF was for short polar chains, but it retained significant activity with a range of cyclic and extended esters. This broad substrate specificity combined with the substitutional analysis demonstrates that the larger binding cleft controls the substrate specificity of Vc‐ybfF. Key selectivity residues (Tyr116, Arg120, Tyr209) are also located at the larger binding pocket and control the substrate specificity profile. In the structure of ybfF the narrower binding cleft contains water molecules prepositioned for hydrolysis, but based on substitution this cleft showed only minimal contribution to catalysis. Instead, the residues surrounding the narrow binding cleft and at the entrance to the binding pocket contributed significantly to the folded stability of Vc‐ybfF. The relative contributions of each cleft of the binding pocket to the catalytic activity and folded stability of Vc‐ybfF provide a valuable map for designing future biocatalysts based on the ybfF scaffold. 相似文献