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11.
Oi-Lam Ng Nathalie Sinclair 《Canadian Journal of Science, Mathematics, & Technology Education》2013,13(1):84-101
AbstractIn this article, we report on two lessons aimed at introducing junior high school students to the idea of shearing in a touchscreen dynamic geometry environment. By using shearing, we hoped to shift students’ attention away from a formula-driven, computational conception of area toward a more geometric one. We found that the students were able to solve several problems involving the comparison of polygons based on verbal and diagrammatic explanations. We describe the features of the touchscreen dynamic geometry technology that supported their learning, as well as the specific role that the teacher played in modeling students’ reasoning about area. 相似文献
12.
Jeanne Volatron Florent Carn Jelena Kolosnjaj‐Tabi Yasir Javed Quoc Lam Vuong Yves Gossuin Christine Ménager Nathalie Luciani Gaëlle Charron Miryana Hémadi Damien Alloyeau Florence Gazeau 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(2)
Proteins implicated in iron homeostasis are assumed to be also involved in the cellular processing of iron oxide nanoparticles. In this work, the role of an endogenous iron storage protein—namely the ferritin—is examined in the remediation and biodegradation of magnetic iron oxide nanoparticles. Previous in vivo studies suggest the intracellular transfer of the iron ions released during the degradation of nanoparticles to endogenous protein cages within lysosomal compartments. Here, the capacity of ferritin cages to accommodate and store the degradation products of nanoparticles is investigated in vitro in the physiological acidic environment of the lysosomes. Moreover, it is questioned whether ferritin proteins can play an active role in the degradation of the nanoparticles. The magnetic, colloidal, and structural follow‐up of iron oxide nanoparticles and proteins in lysosome‐like medium confirms the efficient remediation of potentially harmful iron ions generated by nanoparticles within ferritins. The presence of ferritins, however, delays the degradation of particles due to a complex colloidal behavior of the mixture in acidic medium. This study exemplifies the important implications of intracellular proteins in processes of degradation and metabolization of iron oxide nanoparticles. 相似文献
13.
14.
Surrogate modeling approximation using a mixture of experts based on EM joint estimation 总被引:1,自引:1,他引:0
Dimitri Bettebghor Nathalie Bartoli Stéphane Grihon Joseph Morlier Manuel Samuelides 《Structural and Multidisciplinary Optimization》2011,43(2):243-259
An automatic method to combine several local surrogate models is presented. This method is intended to build accurate and
smooth approximation of discontinuous functions that are to be used in structural optimization problems. It strongly relies
on the Expectation−Maximization (EM) algorithm for Gaussian mixture models (GMM). To the end of regression, the inputs are
clustered together with their output values by means of parameter estimation of the joint distribution. A local expert is
then built (linear, quadratic, artificial neural network, moving least squares) on each cluster. Lastly, the local experts
are combined using the Gaussian mixture model parameters found by the EM algorithm to obtain a global model. This method is
tested over both mathematical test cases and an engineering optimization problem from aeronautics and is found to improve
the accuracy of the approximation. 相似文献
15.
Julien Fleureau Karim Bensalah Denis Rolland Olivier Lavastre Nathalie Rioux-Leclercq François Guillé Jean-Jacques Patard Renaud de Crevoisier Lotfi Senhadji 《Expert systems with applications》2011,38(11):14301-14306
In this study, we propose to evaluate the potential of Raman spectroscopy (RS) to assess renal tumours at surgery. Different classes of Raman renal spectra acquired during a clinical protocol are discriminated using support vector machines classifiers. The influence on the classification scores of various preprocessing steps generally involved in RS are also investigated and evaluated in the particular context of renal tumour characterization. Encouraging results show the interest of RS to evaluate kidney cancer and suggest the potential of this technique as a surgical assistance during partial nephrectomy. 相似文献
16.
Gambling versus Designing: Organizing for the Design of the Probability Space in the Energy Sector 下载免费PDF全文
Sophie Hooge Olga Kokshagina Pascal Le Masson Kevin Levillain Benoit Weil Vincent Fabreguettes Nathalie Popiolek 《Creativity & Innovation Management》2016,25(4):464-483
The objective of this paper is to elucidate an organizational process for the design of generic technologies (GTs). While recognizing the success of GTs, the literature on innovation management generally describes their design according to evolutionary strategies featuring multiple and uncertain trials, resulting in the discovery of common features among multiple applications. This random walk depends on multiple market and technological uncertainties that are considered exogenous: as smart as he can be, the ‘gambler’ must play in a given probability space. However, what happens when the innovator is not a gambler but a designer, i.e., when the actor is able to establish new links between previously independent emerging markets and technologies? Formally speaking, the actor designs a new probability space. Building on a case study of two technological development programmes at the French Center for Atomic Energy, we present cases of GTs that correspond to this logic of designing the probability space, i.e. the logic of intentionally designing common features that bridge the gap between a priori heterogeneous applications and technologies. This study provides another example showing that the usual trial‐and‐learning strategy is not the only strategy to design GTs and that these technologies can be designed by intentionally building new interdependences between markets and technologies. Our main result is that building these interdependences requires organizational patterns that correspond to a ‘design of exploration’ phase in which multiple technology suppliers and application providers are involved in designing both the probability space itself and the instruments to explore and benefit from this new space. 相似文献
17.
Rachel Edita Oñate Roxas Allan Borra Charibeth Ko Cheng Nathalie Rose Lim Ethel Chuajoy Ong Michelle Wendy Tan 《Language Resources and Evaluation》2008,42(2):183-195
In this paper, we present the building of various language resources for a multi-engine bi-directional English-Filipino Machine
Translation (MT) system. Since linguistics information on Philippine languages are available, but as of yet, the focus has
been on theoretical linguistics and little is done on the computational aspects of these languages, attempts are reported
here on the manual construction of these language resources such as the grammar, lexicon, morphological information, and the
corpora which were literally built from almost non-existent digital forms. Due to the inherent difficulties of manual construction,
we also discuss our experiments on various technologies for automatic extraction of these resources to handle the intricacies
of the Filipino language, designed with the intention of using them for the MT system. To implement the different MT engines
and to ensure the improvement of translation quality, other language tools (such as the morphological analyzer and generator,
and the part of speech tagger) were developed. 相似文献
18.
NodeTrix: a hybrid visualization of social networks 总被引:2,自引:0,他引:2
Henry N Fekete JD McGuffin MJ 《IEEE transactions on visualization and computer graphics》2007,13(6):1302-1309
The need to visualize large social networks is growing as hardware capabilities make analyzing large networks feasible and many new data sets become available. Unfortunately, the visualizations in existing systems do not satisfactorily resolve the basic dilemma of being readable both for the global structure of the network and also for detailed analysis of local communities. To address this problem, we present NodeTrix, a hybrid representation for networks that combines the advantages of two traditional representations: node-link diagrams are used to show the global structure of a network, while arbitrary portions of the network can be shown as adjacency matrices to better support the analysis of communities. A key contribution is a set of interaction techniques. These allow analysts to create a NodeTrix visualization by dragging selections to and from node-link and matrix forms, and to flexibly manipulate the NodeTrix representation to explore the dataset and create meaningful summary visualizations of their findings. Finally, we present a case study applying NodeTrix to the analysis of the InfoVis 2004 coauthorship dataset to illustrate the capabilities of NodeTrix as both an exploration tool and an effective means of communicating results. 相似文献
19.
Algorithm performance evaluation is so entrenched in the machine learning community that one could call it an addiction. Like most addictions, it is harmful and very difficult to give up. It is harmful because it has serious limitations. Yet, we have great faith in practicing it in a ritualistic manner: we follow a fixed set of rules telling us the measure, the data sets and the statistical test to use. When we read a paper, even as reviewers, we are not sufficiently critical of results that follow these rules. Here, we will debate what are the limitations and how to best address them. This article may not cure the addiction but hopefully it will be a good first step along that road. 相似文献
20.
Francillette Yannick Boucher Eric Bier Nathalie Lussier Maxime Bouchard Kévin Belchior Patricia Gaboury Sébastien 《User Modeling and User-Adapted Interaction》2020,30(5):895-947
User Modeling and User-Adapted Interaction - Intelligent environments may improve the independence and quality of life of persons with mild cognitive impairment (MCI) or Alzheimer’s disease... 相似文献