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191.
Neda Heydarian Cassandra L. Wouters Andrew Neel Maya Ferrell Hannah Panlilio Tristan Haight Dr. Ph. D. Tingting Gu Prof. Charles V. Rice 《ChemMedChem》2023,18(3):e202200428
Carbapenem-resistant Enterobacteriaceae (CRE) are emerging pathogens that cause variety of severe infections. CRE evade antibiotic treatments because these bacteria produce enzymes that degrade a wide range of antibiotics including carbapenems and β-lactams. The formation of biofilms aggravates CRE infections, especially in a wound environment. These difficulties lead to persistent infection and non-healing wounds. This creates the need for new compounds to overcome CRE antimicrobial resistance and disrupt biofilms. Recent studies in our lab show that 600 Da branched polyethyleneimine (BPEI) and its derivative PEG350-BPEI can overcome antimicrobial resistance and eradicate biofilms in methicillin-resistant S. aureus, methicillin-resistant S. epidermidis, P. aeruginosa, and E. coli. In this study, the ability of 600 Da BPEI and PEG350-BPEI to eradicate carbapenem-resistant Enterobacteriaceae bacteria and their biofilms is demonstrated. We show that both BPEI and PEG350-BPEI have anti-biofilm efficacy against CRE strains expressing Klebsiella pneumoniae carbapenemases (KPCs) and metallo-β-lactamases (MBLs), such as New Delhi MBL (NDM-1). Furthermore, our results illustrate that BPEI affects planktonic CRE bacteria by increasing bacterial length and width from the inability to proceed with normal cell division processes. These data demonstrate the multi-functional properties of 600 Da BPEI and PEG350-BPEI to reduce biofilm formation and mitigate virulence in carbapenem-resistant Enterobacteriaceae. 相似文献
192.
Keresteš Neda Milić Ɖurđević Stefan Novaković Dragoljub Zarić Miroslav Kašiković Nemanja Dedijer Sandra Vladić Gojko 《Universal Access in the Information Society》2023,22(2):351-367
Universal Access in the Information Society - The color vision deficiency, popularly called daltonism or color-blindness, manifests with limited color discrimination ranging from slightly reduced... 相似文献