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排序方式: 共有1791条查询结果,搜索用时 15 毫秒
91.
Viktoriya Sokolova Sebastian Neumann Anna Kovtun Svitlana Chernousova Rolf Heumann Matthias Epple 《Journal of Materials Science》2010,45(18):4952-4957
Nanoparticles with an inner core of calcium phosphate, followed by layers of DNA and calcium phosphate and an outer layer of poly(ethyleneimine) (PEI) were prepared, characterized, and tested on different cell lines (HeLa, T24, and NIH3T3). A considerable increase in transfection efficiency was found for such nanoparticles, compared to the commercial reagent Polyfect® (a cationic dendrimer). The DNA is incorporated into the nanoparticles and protected from the attack by enzymes (nucleases) inside the cytoplasm of cells. The outer layer of PEI leads to electrosteric colloidal stabilization and gives a positive charge to the nanoparticle, which is helpful for the penetration through the negatively charged cell membrane. 相似文献
92.
One Question,Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists
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Dr. Johannes Schiebel Nedyalka Radeva Dr. Helene Köster Dr. Alexander Metz Timo Krotzky Dr. Maren Kuhnert Prof. Wibke E. Diederich Prof. Andreas Heine Dr. Lars Neumann Dr. Cedric Atmanene Dominique Roecklin Dr. Valérie Vivat‐Hannah Dr. Jean‐Paul Renaud Dr. Robert Meinecke Dr. Nina Schlinck Dr. Astrid Sitte Franziska Popp Dr. Markus Zeeb Prof. Gerhard Klebe 《ChemMedChem》2015,10(9):1511-1521
Fragment‐based lead discovery is gaining momentum in drug development. Typically, a hierarchical cascade of several screening techniques is consulted to identify fragment hits which are then analyzed by crystallography. Because crystal structures with bound fragments are essential for the subsequent hit‐to‐lead‐to‐drug optimization, the screening process should distinguish reliably between binders and non‐binders. We therefore investigated whether different screening methods would reveal similar collections of putative binders. First we used a biochemical assay to identify fragments that bind to endothiapepsin, a surrogate for disease‐relevant aspartic proteases. In a comprehensive screening approach, we then evaluated our 361‐entry library by using a reporter‐displacement assay, saturation‐transfer difference NMR, native mass spectrometry, thermophoresis, and a thermal shift assay. While the combined results of these screening methods retrieve 10 of the 11 crystal structures originally predicted by the biochemical assay, the mutual overlap of individual hit lists is surprisingly low, highlighting that each technique operates on different biophysical principles and conditions. 相似文献
93.
F. Völklein H. Reith M. C. Schmitt M. Huth M. Rauber R. Neumann 《Journal of Electronic Materials》2010,39(9):1950-1956
This paper focuses on the determination of thermal and electrical properties of individual thermoelectric nanowires, primarily
bismuth and bismuth compound nanowires, as functions of their crystallinity, diameter, and composition. For measurements of
the Seebeck coefficient and the electrical and thermal conductivity, specially designed microchips have been developed and
employed. Finite-element simulations demonstrate that the temperature profiles of the microchips provide suitable temperature
gradients for Seebeck-effect measurements and heat-sink conditions for thermal conductivity investigations. First measurements
of thermal conductivity of metallic nanowires and of Seebeck coefficients of granular nanowires prepared by focused electron-beam-induced
deposition are presented. Some of these results are discussed in the framework of finite-size-effect theory. 相似文献
94.
The force required to start small, untreated or siliconized glass spheres rolling on an inclined copper-coated glass surface was determined in water and biphenyl melt. The results establish there are van der Waals attractions between the spheres and substrate. Hamaker coefficients of the studied systems were calculated. 相似文献
95.
Reiner Neumann Gabriel Ericson Lima CostaJosé Carlos Gaspar Matheus PalmieriSergio Eduardo e Silva 《Minerals Engineering》2011,24(12):1323-1334
Hydrothermal transformations and weathering are important mineralizing processes in carbonatite-related ores. But the transformation products of mafic minerals, such as the clay minerals, vermiculite and interstratified phases, preclude the use of X-ray diffraction, particularly the Rietveld method, for mineral phase quantification. After treatment with KCl, vermiculite and interstratified phases (all peaks roughly at 1.2, 1.4-1.5 and 2.4 nm) are converted to a phlogopite-like structure with d(0 0 1) = 1.0 nm, which can successfully be refined. The method was tested using three carbonatite-derived ores, with a total phlogopite-like phase content ranging from 1.2 to 32.3 wt.%. Comparison of the chemical analyses with the calculated chemical composition, based on the phase quantification and the mineral composition is in good agreement for major elements, such as Si, Fe and Al. For P results were also very good, but Ti and Nb are generally underestimated, and Ba is overestimated. Minerals with lower contents, as pyrochlore, approach the diffraction detection limit. Problems to accurately determine mineral composition for some of the phases also impacts on the reconciliation. The chemical composition of the pyrochlore group minerals changed, but not to an extent to constrain the usefulness of the technique. Cation exchange successfully extended the amenability of the Rietveld method for phase quantification. 相似文献
96.
Alexander M. Khenkin Ronny Neumann Alexander B. Sorokin Alain Tuel 《Catalysis Letters》1999,63(3-4):189-192
The impregnation of H5PV2Mo10O40 polyoxometalate onto MCM‐41 and amino‐modified MCM‐41 materials provided mesoporous active catalysts with large surface areas
for aerobic hydrocarbon oxidation using isobutyraldehyde as a reducing agent. The results of the oxidation of alkenes and
alkanes gave product selectivities similar to those observed in the corresponding homogeneous reaction although catalytic
activity was somewhat reduced. Under appropriate experimental conditions there was no leaching and the solid catalyst could
be recovered and reused without loss in activity.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
97.
Histamine is a pleiotropic mediator involved in a broad spectrum of (patho)-physiological processes, one of which is the regulation of inflammation. Compounds acting on three out of the four known histamine receptors are approved for clinical use. These approved compounds comprise histamine H1-receptor (H1R) antagonists, which are used to control allergic inflammation, antagonists at H2R, which therapeutically decrease gastric acid release, and an antagonist at H3R, which is indicated to treat narcolepsy. Ligands at H4R are still being tested pre-clinically and in clinical trials of inflammatory diseases, including rheumatoid arthritis, asthma, dermatitis, and psoriasis. These trials, however, documented only moderate beneficial effects of H4R ligands so far. Nevertheless, pre-clinically, H4R still is subject of ongoing research, analyzing various inflammatory, allergic, and autoimmune diseases. During inflammatory reactions in gut tissues, histamine concentrations rise in affected areas, indicating its possible biological effect. Indeed, in histamine-deficient mice experimentally induced inflammation of the gut is reduced in comparison to that in histamine-competent mice. However, antagonists at H1R, H2R, and H3R do not provide an effect on inflammation, supporting the idea that H4R is responsible for the histamine effects. In the present review, we discuss the involvement of histamine and H4R in inflammatory and inflammation-associated diseases of the gut. 相似文献
98.
Michael Sander Rainer Gehring Holger Neumann Thomas Jordan 《International Journal of Hydrogen Energy》2012
A new energy storage concept for variable renewable energy, LIQHYSMES, has been proposed which combines the use of LIQuid HYdrogen (LH2) with Superconducting Magnetic Energy Storage (SMES). LH2 with its high volumetric energy density and, compared with compressed hydrogen, increased operational safety is a prime energy carrier for large scale stationary energy storage. But balancing load or supply fluctuations from seconds to several hours with hydrogen alone is difficult due to the response times of the flow control, and an additional short-term electrical energy storage will be needed. For this purpose a compact LIQHYSMES Storage Unit is proposed which integrates the H2 liquefaction part, the LH2 tank and the SMES based on Magnesium Diboride and cooled by the LH2 bath. This allows jointly utilizing the cryogenic infrastructure and reducing the otherwise significant H2 liquefaction losses by introducing a novel process with “cold recovery”. Preliminary target numbers for this process, key parameters for a complete LIQHYSMES model plant, simulations on the anticipated buffering behaviour, a loss analysis and a crude cost estimate are given. 相似文献
99.
The existing theoretical modelling of thermoacoustic oscillations has been studied and applied to the case of tunnel fires. The assumptions of the theoretical model were reviewed. It was found that several assumptions are not applicable to tunnel fires and, hence, suggestions for improvement are given. The correlation which expresses the starting conditions for thermoacoustic oscillations is analysed and dependencies on different parameters are presented. The pulsations documented during the large-scale tests in the Runehamar tunnel in 2003 have also been further analysed. The measurements were compared to the theoretical limiting curve for oscillations, showing good agreement. To further study thermoacoustic oscillations in tunnels, more detailed tests in a model-scale tunnel (1:100) were performed. These tests focused on the circumstances which are required to create thermoacoustic oscillations, i.e. the fire was located at different positions along the tunnel and the air flow rate was varied. The tunnel had a length of 4 m, was 8 cm wide and 6 cm high. The results were in good accordance with the theoretical modelling but showed deviations which were most obvious at very low and high air velocities. Both the starting conditions for thermoacoustic oscillations and cases where the thermoacoustic oscillations suddenly stopped, were observed. These findings led to identification of several points in the theoretical model which need to be improved, and to the development of a strategy to avoid such pulsation in fires. 相似文献
100.
The paper presents simple, physically plausible, but not physically based reflectance models for metals and other specular materials. So far there has been no metallic BRDF model that is easy to compute, suitable for fast importance sampling and is physically plausible. This gap is filled by appropriate modifications of the Phong, Blinn and the Ward models. The Phong and the Blinn models are known not to have metallic characteristics. On the other hand, this paper also shows that the Cook-Torrance and the Ward models are not physically plausible, because of their behavior at grazing angles. We also compare the previous and the newly proposed models. Finally, the generated images demonstrate how the metallic impression can be provided by the new models. 相似文献