大型汽轮发电机组调峰的综合评价与优化分析

提出对大型汽轮机组调峰运行进行综合评价的方法，并基于煤耗和转子寿命损耗建立了对机组调峰进行总体优化的数学模型。这种以综合评价指标最小为目标进行优化的方法，较以往只考虑单方面的优化方法更科学、合理而且全面。     

Scale-effects on mean and standard deviation of the mechanical properties of condensed matter: an energy-based unified approach

The size effects on the mean values of the mechanical properties of condensed matter and on the related variances are analysed by means of a unified approach based on the multiscale character of energy dissipation. In particular, the scaling law for fragmentation energy density is obtained taking into account the self-similarity of fragments. It is based on a generalization of the three classical comminution laws that has been performed to evaluate the energy dissipation, computing volume and surface area of the particles for one- two- and three-dimensional fragmented objects. The result is general and can be applied to different fractal energy dissipation mechanisms, e.g., plasticity. Based on this approach, the scaling laws for mean and standard deviation values of the main mechanical properties of materials can be derived, like Young's and shear elastic moduli, ultimate normal and shear stresses and strains, fracture energy and toughness.     

电力负荷管理系统的现状及发展

介绍了电力负荷管理系统的基本现状，并对该系统为适应新形势下供电部门的需求而必须完善和加强的功能做了详细的说明。     

跨变台电力远程抄表系统的原理及应用

介绍了工频过零调制通信的基本原理，及以该技术为核心的远程抄表系统的应用。     

浅析网络安全技术

就信息网络安全内涵发生的根本变化,阐述了安全体系的重要性及建立网络安全体系的必要性。介绍了网络防火墙安全技术的分类及其主要技术特征。     

高压输电线路铁塔选型漫谈

本文结合近几年来,我国高压输电线路铁塔选型方面的基本情况,和作者本人从事高压输电线路铁塔结构设计中的一些经验和看法,简述了大负荷、新结构的塔型使用现状和铁塔选型应注意的一些问题。     

关于管理信息化工作的思考

本文探讨在管理信息化工作的关键内容,分析了信息、信息工具与管理工作的关系,强调信息数据的重要性。认为信息是管理工作的主要内容,信息的载体从纸张介质向电磁介质转化,信息工具因此发生了重要变化。管理工作是对工作中产生的信息进行处理,信息量的大小决定了组织结构,信息的如何处理决定了管理的工作流程。管理信息化工作要从信息载体变化的前提出发,考虑这个转变所带来的各种困难,充分应用信息工具的各种资源。在管理信息化工作中应考虑企业的成本和效益。管理系统应从业务出发,打破部门的界限,从数据源头开始,着重考虑权限的榨制,增强灵活性和适应性。     

电缆故障指示器及其使用情况评析

本文通过介绍近年来在广州供电分公司配网中使用较为广泛的三种电缆故障指示器,分析论述了其在查找故障点等方面的优势,同时也指出了其在使用过程中存在的问题,并提出了解决问题的方法。     

Tradeoff Analysis for RMS of Equipment Based Operation Availability and Life Cycle Cost

Reliability, maintainability, supportability (RMS) are the important performance indexes of equipment, which affect not only the availability, but also the life cycle cost (LCC) of the equipment. First discussed is the qualitative relation between reliability and LCC and the costs which may be used to enhance the reliability. Secondly, the factors that affect the maintainability are summarized, and if maintainability is advanced, the trend of the LCC is depicted. Thirdly, the qualitative relation between th...     

A Novel Human Neutralizing mAb Recognizes Delta,Gamma and Omicron Variants of SARS-CoV-2 and Can Be Used in Combination with Sotrovimab

The dramatic experience with SARS-CoV-2 has alerted the scientific community to be ready to face new epidemics/pandemics caused by new variants. Among the therapies against the pandemic SARS-CoV-2 virus, monoclonal Antibodies (mAbs) targeting the Spike glycoprotein have represented good drugs to interfere in the Spike/ Angiotensin Converting Enzyme-2 (ACE-2) interaction, preventing virus cell entry and subsequent infection, especially in patients with a defective immune system. We obtained, by an innovative phage display selection strategy, specific binders recognizing different epitopes of Spike. The novel human antibodies specifically bind to Spike-Receptor Binding Domain (RBD) in a nanomolar range and interfere in the interaction of Spike with the ACE-2 receptor. We report here that one of these mAbs, named D3, shows neutralizing activity for virus infection in cell cultures by different SARS-CoV-2 variants and retains the ability to recognize the Omicron-derived recombinant RBD differently from the antibodies Casirivimab or Imdevimab. Since anti-Spike mAbs, used individually, might be unable to block the virus cell entry especially in the case of resistant variants, we investigated the possibility to combine D3 with the antibody in clinical use Sotrovimab, and we found that they recognize distinct epitopes and show additive inhibitory effects on the interaction of Omicron-RBD with ACE-2 receptor. Thus, we propose to exploit these mAbs in combinatorial treatments to enhance their potential for both diagnostic and therapeutic applications in the current and future pandemic waves of coronavirus.