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91.
Tablets containing two different doses of ibuprofen are realized. The first possesses very fast release kinetics, while the second has slow and linear release kinetics. This allows drug to produce a therapeutic effect quickly and to maintain it for a long time with only one administration unit. Such tablets are obtained by compression of a mixture of two very different kinds of granulates: an ibuprofen-starch granulate and an ibuprofen-Eudragit RS microsphere granulate. Specific proportions of mixtures of them give the described result after compression at particular tablet hardnesses. 相似文献
92.
93.
Need for recovery from work: evaluating short-term effects of working hours,patterns and schedules 总被引:1,自引:0,他引:1
In this paper working hours, patterns and work schedules of employees were evaluated in terms of need for recovery from work. Self-administered questionnaire data from employees of the Maastricht Cohort Study on Fatigue at Work (n = 12,095) were used. Poisson regression analyses and multivariate logistic regression analyses revealed that higher working hours a day and working hours a week generally went together with more need for recovery from work. Overtime work was particularly associated with higher need for recovery from work in both genders. Both male and female three-shift or irregular shift workers had higher odds of elevated need for recovery compared to day workers. When additionally controlling for work-related factors, need for recovery levels among shift workers substantially lowered. This study clearly showed that working hours and schedules are associated with need for recovery from work, with different associations for men and women. Especially the associations between work schedules and need for recovery from work were very interrelated with other work-related factors. Future studies could further investigate the possibility that shift work might function as a proxy of other work-related factors that explain the different levels in need for recovery from work, or that job demands are perceived higher among shift workers and may therefore lead to more need for recovery from work. 相似文献
94.
Erdmann N Betti M Kollmer F Benninghoven A Grüning C Philipsen V Lievens P Silverans RE Vandeweert E 《Analytical chemistry》2003,75(13):3175-3181
The resonance and nonresonant laser ionization of uranium atoms sputtered from thin metal films and individual micrometer-size uranium oxide particles, respectively, was studied to evaluate a new setup for the analysis of actinide-containing micrometer-size particles. Experiments using nonresonant (193-nm) ionization of atoms and molecules sputtered from micrometer-size uranium oxide particles have shown that the uranium detection efficiencies for sputtered neutral atoms are approximately 2 orders of magnitude higher than for secondary ions. In uranium particles of 0.5-microm diameter, 6 x 10(6) atoms of 235U were easily detected and the isotopic ratio of 235U/238U = 0.0048 +/- 4.6% is in excellent agreement with the certified value. The use of two-color, two-step resonance ionization of the sputtered neutral uranium atoms from thin films was investigated. Several excitation schemes were tested, and a significant population of several low-lying metastable states after ion sputtering was observed. Autoionizing states for double-resonant ionization were determined, and the high selectivity of ionization schemes involving these autoionizing states was illustrated by comparing the flight-time distributions of different sputtered species obtained both by resonance and nonresonant multiphoton (355-nm) laser postionization. Ideally, the options for resonance as well as nonresonant ionization would be combined in a single setup, to obtain a large gain in sensitivity and selectivity. Thus, information about the main components as well as specific isotopic information of a trace element could be obtained from the same single particle. 相似文献
95.
96.
Measurement of Gas Transport through Fiber Preforms and Densified Composites for Chemical Vapor Infiltration 总被引:1,自引:0,他引:1
Gas transport via pressure-driven permeation or via concentration-driven diffusion is a key step in the chemical vapor infiltration (CVI) process. This paper describes methods for the measurement of these properties for CVI preforms and partially infiltrated composites. Results are presented for Nicalon-fiber cloth layup preforms and composites, Nextel-fiber braid preforms and composites, and a Nicalon-fiber three-dimensional (3-D) weave composite. The permeability of Nicalon cloth layup preforms is strongly dependent on the packing density over the range of 29-40 vol% but is only weakly dependent on the orientation of the alternating cloth layers. The specimen-to-specimen variation is high (standard deviation of 20%), which reflects the statistical nature of the interlayer separation and alignment. This variability also affects the results for the partially densified specimens, where the permeability values for specimens of similar density can be very different. Trends in the diffusion factor results are similar to those for permeability, which reflects the fact that both transport parameters are dependent on the structure of the same pore network, although in somewhat different ways. The permeability of Nextel braid preforms is dependent on the thread count and the weight for cloths with similar construction and packing density. The gas permeability of the finer wave (6.3 tows/cm (16 tows/in.)) is approximately one-half that of the coarser weave (3.5 tows/cm (9 tows/in.)). Results are reported for a small number of infiltrated composites with Nextel fiber reinforcement. Attempts to mount a Nicalon-fiber 3-D weave preform specimen have been unsuccessful. Results for a small number of composite specimens with 3-D weave reinforcement are reported. 相似文献
97.
This paper reports early steps in research that seeks to clarify how publications of scientists interact dynamically with
citations and reputation in shaping the evolution of scientific fields. We assume that Lotka's modified law holds for scientific
fields. A primary approach to model publication productivity was published by Yablonsky. In contrast to Yablonsky's unfinished
mathematical approach, our simulation approach is not predominantly driven by insight into the formal generation mechanisms
of certain processes but more theory driven. It considers the evolution of publication and citation distributions over the
histories of scientific fields using both simulated and real historical data. 相似文献
98.
Conrad Nicole J.; Walsh Jennifer; Allen Jennifer M.; Tsang Christine D. 《Canadian Metallurgical Quarterly》2011,65(3):168
Caregivers around the world sing to their infants. Infants not only prefer to listen to infant-directed singing over adult-directed singing, but infant-directed singing also serves a function, communicating affective information to preverbal infants to aid in adjusting arousal levels. Pitch variation has previously been identified as one performance feature that may help to convey the message. Earlier research has indicated that infants' pitch preferences are context dependent, suggesting that infants are tuned in to the communicative intent of infant-directed singing. However, there are several other performance-based features present in infant-directed singing that may also contribute to the affective message. The current study examined the role of context on infants' tempo preferences in sung playsongs and lullabies. Using a head-turn preference procedure, we measured 24 preverbal infants' natural preferences for foreign language playsongs and lullabies as a function of tempo. Infants showed a preference for fast over slow tempo playsongs, but no such context dependent preference was found within lullabies. Results partially support the role of tempo as a communicative feature of infant directed singing. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
99.
Nicole Schmidt 《Datenschutz und Datensicherheit - DuD》2009,33(2):107-109
Der BGH hat am 16.07.2008 (DuD 2008, 751) die Einwilligungsl?sung für die Zusendung von Werbung per Post, SMS oder E-Mail
von Unternehmen an Kunden im Zusammenhang mit der Kundenkarte Payback bewertet. Als Konsequenz ist nun der Gesetzgeber gefordert,
einen einheitlichen Einwilligungsstandard festzulegen. 相似文献
100.
Eric S. Toberer Alexandra Zevalkink Nicole Crisosto G. Jeffrey Snyder 《Advanced functional materials》2010,20(24):4375-4380
Understanding transport in Zintl compounds is important due to their unusual chemistry, structural complexity, and potential for good thermoelectric performance. Resistivity measurements indicate that undoped Ca5Al2Sb6 is a charge‐balanced semiconductor with a bandgap of 0.5 eV, consistent with Zintl–Klemm charge counting rules. Substituting divalent calcium with monovalent sodium leads to the formation of free holes, and a transition from insulating to metallic electronic behavior is observed. Seebeck measurements yield a hole mass of ~2me, consistent with a structure containing both ionic and covalent bonding. The structural complexity of Zintl compounds is implicated in their unusually low thermal conductivity values. Indeed, Ca5Al2Sb6 possesses an extremely low lattice thermal conductivity (0.6 W mK?1 at 850 K), which approaches the minimum thermal conductivity limit at high temperature. A single parabolic band model is developed and predicts that Ca4.75Na0.25Al2Sb6 possesses a near‐optimal carrier concentration for thermoelectric power generation. A maximum zT > 0.6 is obtained at 1000 K.Beyond thermoelectric applications, the semiconductor Ca5Al2Sb6 possesses a 1D covalent structure which should be amenable to interesting magnetic interactions when appropriately doped. 相似文献